https://m2.mtmt.hu/ hun 2026-09-22 14:35 JournalArticle 34477401 VALIDATED true 0 false 2026-09-15T10:56:20.490+0000 2026-05-18T02:46:03.057+0000 2024-01-04T11:49:56.838+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-07-10T08:51:43.826+0000 2024-03-13T10:36:52.432+0000 true 10065569 Pécsi Éva /api/admin/10065569 Admin true 2026-05-18T02:46:02.958+0000 true 521 Szuper Admin /api/admin/521 Admin true Admin 10065569 /api/admin/10065569 Pécsi Éva true true Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2024-01-15T13:05:27.107+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Mukli, Peter Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction true true /api/journal/10058183 REVIEWED true false 10058183 false 10058183 true 2198-3844 Journal FOREIGN 11 10 e2303516 e2303516 18 2024 Impaired cerebrovascular function contributes to the genesis of age-related cognitive decline. In this study, the hypothesis is tested that impairments in neurovascular coupling (NVC) responses and brain network function predict cognitive dysfunction in older adults. Cerebromicrovascular and working memory function of healthy young (n = 21, 33.2±7.0 years) and aged (n = 30, 75.9±6.9 years) participants are assessed. To determine NVC responses and functional connectivity (FC) during a working memory (n-back) paradigm, oxy- and deoxyhemoglobin concentration changes from the frontal cortex using functional near-infrared spectroscopy are recorded. NVC responses are significantly impaired during the 2-back task in aged participants, while the frontal networks are characterized by higher local and global connection strength, and dynamic FC (p < 0.05). Both impaired NVC and increased FC correlate with age-related decline in accuracy during the 2-back task. These findings suggest that task-related brain states in older adults require stronger functional connections to compensate for the attenuated NVC responses associated with working memory load. Funding 2035408 /api/funding/2035408 false true Funding 2035409 /api/funding/2035409 false true true 2024 true true true false true false GOLD 2026-09-15 true https://doi.org/10.1002/advs.202303516 46 0 43 25 12 43 43 45 43 46 43 26 25 26 20 0 46 26 43 25 0 19 19 Folyóiratcikk Journal Article 24 43 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 2 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 12 3 12 3 2025 0 22 12 22 12 2026 0 12 11 12 11 D1 false false false false 2024-03-12T09:08:18.107+0000 Doktori Iskola (SE); ELKH-PTE Klinikai Idegtudományi Képalkotó Kutat... (PTE / KCS); Idegsebészeti Klinika (PTE / ÁOK); Kardiológiai Tanszék (DE / ÁOK / KardI); Népegészségtani Intézet (SE / AOK / I); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Intézet (SE / AOK / I); Élettani Intézet (SE / AOK / I) 11 55 8 25 0 true 10025544 10065569 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 113635604 /api/authorship/113635604 1 0.04 true false false Author 10032249 /api/author/10032249 Mukli Péter true 10032249 true Mukli Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635605 /api/authorship/113635605 2 0.04 false false false Pinto Camila B true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635606 /api/authorship/113635606 3 0.04 false false false Owens Cameron D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635607 /api/authorship/113635607 4 0.04 false false false Author 10055259 /api/author/10055259 Csípő Tamás true 10055259 true Csipo Tamas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635608 /api/authorship/113635608 5 0.04 false false false Author 10075114 /api/author/10075114 Lipécz Ágnes true true Lipecz Agnes true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635609 /api/authorship/113635609 6 0.04 false false false Author 10078855 /api/author/10078855 Szarvas Zsófia true true Szarvas Zsofia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635610 /api/authorship/113635610 7 0.04 false false false Author 10084061 /api/author/10084061 Péterfi Anna true true Peterfi Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635611 /api/authorship/113635611 8 0.04 false false false Langley Ana Clara da Costa Pinaffi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635612 /api/authorship/113635612 9 0.04 false false false Hoffmeister Jordan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635613 /api/authorship/113635613 10 0.04 false false false Author 10059431 /api/author/10059431 Rácz Frigyes Sámuel true 10059431 true Racz Frigyes Samuel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635614 /api/authorship/113635614 11 0.04 false false false Perry Jonathan W true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635615 /api/authorship/113635615 12 0.04 false false false Author 10074557 /api/author/10074557 Tarantini Stefano true true Tarantini Stefano true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635616 /api/authorship/113635616 13 0.04 false false false Author 10045003 /api/author/10045003 Nyúl-Tóth Ádám true 10045003 true Nyúl-Tóth Ádám true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635617 /api/authorship/113635617 14 0.04 false false false Sorond Farzaneh A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635618 /api/authorship/113635618 15 0.04 false false false Yang Yuan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635619 /api/authorship/113635619 16 0.04 false false false James Judith A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635620 /api/authorship/113635620 17 0.04 false false false Kirkpatrick Angelia C true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635621 /api/authorship/113635621 18 0.04 false false false Prodan Calin I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635622 /api/authorship/113635622 19 0.04 false false false Author 10021094 /api/author/10021094 Tóth Péter József true 10021094 true Toth Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635623 /api/authorship/113635623 20 0.04 false false false Galindo Juliette true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635624 /api/authorship/113635624 21 0.04 false false false Gardner Andrew W true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635625 /api/authorship/113635625 22 0.04 false false false Sonntag William E true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635626 /api/authorship/113635626 23 0.04 false false false Author 10071157 /api/author/10071157 Csiszar Anna true true Csiszar Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635627 /api/authorship/113635627 24 0.04 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 113635628 /api/authorship/113635628 25 0.04 false true true Yabluchanskiy Andriy true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25213286 /api/publicationidentifier/25213286 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1002/advs.202303516 https://doi.org/10.1002/advs.202303516 false true PublicationIdentifier 25247379 /api/publicationidentifier/25247379 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false 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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38155460&dopt=Abstract false true Keyword 6341 /api/keyword/6341 true 6341 true Keyword 1070178 /api/keyword/1070178 true 1070178 true Keyword 1084437 /api/keyword/1084437 true 1084437 true Keyword 1246653 /api/keyword/1246653 true 1246653 true Keyword 1453726 /api/keyword/1453726 true 1453726 true SjrRating 11462859 /api/sjrrating/11462859 3 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2201 /api/classificationexternal/2201 true 2201 true D1 DIRECT true true /api/publication/34477401 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli Peter (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Pinto Camila B </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Owens Cameron D </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055259"><a href="/gui2/?type=authors&mode=browse&sel=10055259" target="_blank">Csipo Tamas (<span class="authorship-author-name">Csípő Tamás</span> <span class="authorAux-mtmt"> kardiológia, vaszkuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Kardiológiai Intézet">KardI</span>/Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075114"><a href="/gui2/?type=authors&mode=browse&sel=10075114" target="_blank">Lipecz Agnes (<span class="authorship-author-name">Lipécz Ágnes</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078855"><a href="/gui2/?type=authors&mode=browse&sel=10078855" target="_blank">Szarvas Zsofia (<span class="authorship-author-name">Szarvas Zsófia</span> <span class="authorAux-mtmt"> Megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084061"><a href="/gui2/?type=authors&mode=browse&sel=10084061" target="_blank">Peterfi Anna (<span class="authorship-author-name">Péterfi Anna</span> <span class="authorAux-mtmt"> Megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Langley Ana Clara da Costa Pinaffi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoffmeister Jordan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059431"><a href="/gui2/?type=authors&mode=browse&sel=10059431" target="_blank">Racz Frigyes Samuel (<span class="authorship-author-name">Rácz Frigyes Sámuel</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Perry Jonathan W </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini Stefano (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045003"><a href="/gui2/?type=authors&mode=browse&sel=10045003" target="_blank">Nyúl-Tóth Ádám (<span class="authorship-author-name">Nyúl-Tóth Ádám</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sorond Farzaneh A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yang Yuan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >James Judith A </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kirkpatrick Angelia C </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Prodan Calin I </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021094"><a href="/gui2/?type=authors&mode=browse&sel=10021094" target="_blank">Toth Peter (<span class="authorship-author-name">Tóth Péter József</span> <span class="authorAux-mtmt"> Idegsebészet, cerebrovaszkuláris kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Idegsebészeti Klinika; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Transzlációs Medicina Intézet; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Kutatócsoportok">KCS</span>/ELKH-PTE Klinikai Idegtudományi Képalkotó Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Galindo Juliette </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gardner Andrew W </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Sonntag William E </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar Anna (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Zoltan (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy Andriy ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34477401" target="_blank">Impaired Neurovascular Coupling and Increased Functional Connectivity in the Frontal Cortex Predict Age-Related Cognitive Dysfunction</a></div> <div> <span class="journal-title">ADVANCED SCIENCE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2198-3844">2198-3844</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">10</span> <span class="page"> Paper e2303516. 18 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1002/advs.202303516" target="_blank" href="https://doi.org/10.1002/advs.202303516"> DOI </a> </span> 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href="/api/publication?cond=citations.related;eq;34477401&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 19 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34477401</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (TKP2021-NKTA-47), (RRF-2.3.1-21-2022-00003) </div> <div class="lastModified">Utolsó módosítás: 2026.05.18. 04:46 Szuper Admin (admin) </div> <div class="lockedBy">Központi kezelésű 2024.01.15. 14:05 Pécsi Éva (MTMT Közp 2,3, admin) Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>