Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial

https://m2.mtmt.hu/ hun 2026-05-25 20:39 JournalArticle 34470827 VALIDATED true Population Health Research Institute, McMaster University, Hamilton, ON, Canada Hospital Universitari Vall d'Hebron, Barcelona, Spain National Cerebral and Cardiovascular Center, Suita, Osaka, Japan Semmelweis University, Budapest, Hungary Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States Department of Neurology, Oregon Health & Science University, Portland, OR, United States Second Department of Neurology, National and Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece Department of Internal Medicine, University of Thessaly, Larissa, Greece 2nd Department of Neurology, Institute of Psychiatry and Neurology, Warsaw, Poland Division of Neurology, Department of Medicine, University of Alberta Hospital, Edmonton, AB, Canada Department of Neurology and Stroke Center, University of Paris, Bichat Hospital, Paris, France Department of Neurology and Center for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany Uijeongbu Eulji Medical Center, Eulji University, Gyeonggi-do, South Korea Stroke and Cognition Institute, Rambam Health Care Campus, Technion, Haifa, Israel Emergency Department Stroke Unit, Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy Stroke Unit and Neurovascular Center Antwerp, Department of Neurology, Antwerp University Hospital, Antwerp (Edegem), Belgium Department of Neurology, Aarhus University Hospital, Aarhus, Denmark Universidade Federal de São Paulo/UNIFESP and Hospital Israelita Albert Einstein, São Paulo, Brazil Centro Internacional de Pesquisa, Hospital Alemão Oswaldo Cruz, São Paulo, Brazil School of Cardiovascular and Metabolic Health, College of Medical, Veterinary & Life Sciences, Queen Elizabeth University Hospital, Glasgow, United Kingdom Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland Department of Clinical Neuroscience/Neurology, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg and Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden Department of Internal Medicine and Department of Digitalization & ICT, University Hospital Basel, Basel, Switzerland Servicio de Neurología Vascular, Departamento de Neurología, FLENI, Buenos Aires, Argentina Department of Neurology, Klinikum Klagenfurt, Austria Department of Neurology, Oslo University Hospital and The Norwegian Air Ambulance Foundation, Oslo, Norway National Medical Research Center of Cardiology after E Chazov, Moscow, Russian Federation Departamento de Neurología y Psiquiatría, Unidad de Investigación y Ensayos Clínicos, Clínica Alemana, Universidad del Desarrollo, Santiago, Chile Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, México City, Mexico Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States Department of Neuroepidemiology, Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Duisburg-Essen, Essen, Germany Davee Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States University of Lille, Lille, Inserm, CHU Lille, U1172 – LiINCog – Lille Neuroscience & Cognition, Lille, F-59000, France Bristol Myers Squibb, Princeton, NJ, United States Medical School, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Perth, WA, Australia Perron Institute for Neurological and Translational Science, Perth, Australia Cited By :1 Export Date: 5 January 2024 CODEN: LNAEA Correspondence Address: Sharma, M.; Population Health Research InstituteCanada; email: mike.sharma@phri.ca Chemicals/CAS: acetylsalicylic acid, 493-53-8, 50-78-2, 53663-74-4, 53664-49-6, 63781-77-1; blood clotting factor 11a; milvexian, 1802425-99-5; Aspirin; Factor XIa; milvexian 0 false 2026-05-23T11:17:57.676+0000 2024-01-02T07:32:28.891+0000 2024-01-02T07:18:42.563+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true 2025-09-22T08:21:08.535+0000 2024-01-02T07:32:28.900+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType Sokszerzős vagy csoportos szerzőségű szakcikk (Folyóiratcikk) 104 true 10000359 true 1 /api/category/1 Category Tudományos true 1 Sharma, M. 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Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial. (2024) LANCET NEUROLOGY 1474-4422 1474-4465 23 1 46-59<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Sharma M. ✉ </span> ;    <span class="author-name" mtid="10000800"><a href="/gui2/?type=authors&mode=browse&sel=10000800" target="_blank">Bereczki D. (<span class="authorship-author-name">Bereczki Dániel</span> <span class="authorAux-mtmt"> Stroke</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Neurológiai Klinika</span> ;    et al. (40) </div> <div><a target="_blank" href="/api/publication/34470827?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34470827" target="_blank">Safety and efficacy of factor XIa inhibition with milvexian for secondary stroke prevention (AXIOMATIC-SSP): a phase 2, international, randomised, double-blind, placebo-controlled, dose-finding trial</a></div> <div> <span class="journal-title">LANCET NEUROLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-4422">1474-4422</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1474-4465">1474-4465</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">1</span> <span class="page"> pp 46-59 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1016/S1474-4422(23)00403-9" target="_blank" href="https://doi.org/10.1016/S1474-4422%2823%2900403-9"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001146602800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001146602800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85179817682" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85179817682"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38101902" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38101902&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neurology (clinical)   SJR indikátor: D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 79</span> | Független: 65 | Függő: 14 | Nem jelölt: 0 | WoS jelölt: 72 | Scopus jelölt: 73 | WoS/Scopus jelölt: 79 | DOI jelölt: 79 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34470827&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34470827</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2024.01.02. 08:32 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Population Health Research Institute, McMaster University, Hamilton, ON, Canada Hospital Universitari Vall d'Hebron, Barcelona, Spain National Cerebral and Cardiovascular Center, Suita, Osaka, Japan Semmelweis University, Budapest, Hungary Department of Health Research Methods, Evidence, and Impact, ...</pre> </div></div>