https://m2.mtmt.hu/ eng 2026-10-23 03:48 JournalArticle 34413258 VALIDATED true Export Date: 10 December 2024 CODEN: CLPTA Correspondence Address: Csupor, D.; Centre for Translational Medicine, Hungary; email: csupor.dezso@szte.hu 0 false 2026-10-21T09:23:37.505+0000 2024-12-06T18:06:50.350+0000 2023-12-04T09:01:19.364+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 2026-10-21T09:20:53.402+0000 2024-12-06T18:06:50.604+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Horváth, István László true true /api/journal/1078 REVIEWED CLINICAL PHARMACOLOGY & THERAPEUTICS 0009-9236 1532-6535 true false 1078 false 1078 true 0009-9236 1532-6535 Journal FOREIGN 115 2 206 212 206 7 2024 Pancreatitis is the most common complication of endoscopic retrograde cholangiopancreatography (ERCP). As the management of pancreatitis is limited, clinical approaches focus on the prevention of post-ERCP pancreatitis (PEP). In theory, the serine protease inhibitor nafamostat can reduce circulating inflammatory mediators in pancreatitis. We aimed to investigate the effect of nafamostat in the prevention of PEP in this systematic review and meta-analysis. The protocol for this review was registered in PROSPERO (CRD42022367988). We systematically searched five databases without any filters on 26th September 2022. The eligible population was adult patients undergoing ERCP. We compared the PEP preventive effect of nafamostat to placebo. The main outcome was the occurrence of PEP. We calculated the pooled odds ratios (OR), mean differences (MD), and corresponding 95% confidence intervals (95%CI) and multilevel model. The risk of bias was assessed using the Rob2 tool. Seven randomized controlled trials involving 2,962 patients were eligible for inclusion. Nafamostat reduced the overall incidence rate of PEP [20 mg OR 0.50; 95%CI 0.30-0.82 and 50 mg 0.48; 95%CI 0.24-0.96]. However, the occurrence of mild PEP was significantly reduced only in the subgroup receiving 20 mg nafamostat [OR 0.49; 95%CI 0.31-0.77]. Overall, nafamostat therapy reduced moderate PEP in high-risk patients [OR 0.18; 95%CI 0.0.4-0.84] and mild PEP in low-risk patients [OR 0.32; 95%CI 0.17-0.61]. Nafamostat is an effective therapy in the prevention of mild post-ERCP pancreatitis. Further research is required to determine the cost-effectiveness of this therapy. true 2023 true true true false true false GOLD 2026-10-21 true https://doi.org/10.1002/cpt.3118 6 0 6 6 0 6 6 5 5 6 6 6 6 6 0 0 6 6 6 6 0 7 7 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 6 6 6 6 D1 false 10081469,10001143 false false false 2024-01-11T09:25:38.714+0000 Biostatisztika tanszék (ÁTE / GBI); Egyetemi Gyógyszertár Gyógyszerügyi Szervezési ... (SE / GYTK); Klinikai Gyógyszerészeti Intézet (SZTE / GYTK); Pankreász Betegségek Intézete (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE) 7 62 6 7 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 113103134 /api/authorship/113103134 Horváth, István László [Horváth, István László (gyógyszerész), author] University Pharmacy Department of Pharmacy Admi... (SU / FP); Centre for Translational Medicine (SU / KSZE) 1 0.143 true false false Author 10079182 /api/author/10079182 István László Horváth (gyógyszerész) Horváth István László true true Horváth István László true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113103135 /api/authorship/113103135 Kleiner, Dénes [Kleiner, Dénes (gyógyszerész), author] University Pharmacy Department of Pharmacy Admi... (SU / FP); Centre for Translational Medicine (SU / KSZE) 2 0.143 false false false Author 10059913 /api/author/10059913 Dénes Kleiner (gyógyszerész) Kleiner Dénes true 10059913 true Kleiner Dénes true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113103136 /api/authorship/113103136 Nagy, Rita [Nagy, Rita (Gyermekgyógyászat), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE) 3 0.143 false false false Author 10081469 /api/author/10081469 Rita Nagy (Gyermekgyógyászat) Nagy Rita true true Nagy Rita true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113103137 /api/authorship/113103137 Fehérvári, Péter [Fehérvári, Péter (Biomatematika), author] Centre for Translational Medicine (SU / KSZE); Department of Biostatistics (UVMB / IEB) 4 0.143 false false false Author 10023284 /api/author/10023284 Péter Fehérvári (Biomatematika) Fehérvári Péter true 10023284 true Fehérvári Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113103138 /api/authorship/113103138 Hankó, Balázs [Hankó, Balázs (gyógyszerügyi sze...), author] University Pharmacy Department of Pharmacy Admi... (SU / FP) 5 0.143 false false false Author 10020592 /api/author/10020592 Balázs Hankó (gyógyszerügyi szervezéstan) Hankó Balázs true 10020592 true Hankó Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113103139 /api/authorship/113103139 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE); Institute of Pancreatic Diseases (SU / FM / C) 6 0.143 false false false Author 10002629 /api/author/10002629 Péter Hegyi (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 113103140 /api/authorship/113103140 Csupor, Dezső ✉ [Csupor, Dezső (Klinikai gyógysze...), author] Department of Clinical Pharmacy (SZTE / FP); Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE) 7 0.143 false true true Author 10001143 /api/author/10001143 Dezső Csupor (Klinikai gyógyszerészet; Fitokémia) Csupor Dezső true 10001143 true Csupor Dezső true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 25056871 /api/publicationidentifier/25056871 DOI: 10.1002/cpt.3118 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1002/cpt.3118 https://doi.org/10.1002/cpt.3118 false true PublicationIdentifier 25280326 /api/publicationidentifier/25280326 WoS: 001133868900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001133868900001 https://www.webofscience.com/wos/woscc/full-record/001133868900001 false true PublicationIdentifier 25247367 /api/publicationidentifier/25247367 Scopus: 85180837995 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85180837995 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85180837995 false true PublicationIdentifier 25056870 /api/publicationidentifier/25056870 PubMed: 38032816 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38032816 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38032816&dopt=Abstract false true PublicationIdentifier 25346046 /api/publicationidentifier/25346046 SZTE Publicatio: 29392 SwordSource 90 /api/publicationsource/90 SZTE Publicatio PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 29392 http://publicatio.bibl.u-szeged.hu/29392 false true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true SjrRating 11491527 /api/sjrrating/11491527 sjr:D1 (2024) Scopus - Pharmacology (medical) CLINICAL PHARMACOLOGY & THERAPEUTICS 0009-9236 1532-6535 11 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2736 /api/classificationexternal/2736 Scopus - Pharmacology (medical) true 2736 true D1 DIRECT true true /api/publication/34413258 Horváth István László et al. Nafamostat Reduces the Incidence of post-ERCP Pancreatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. (2024) CLINICAL PHARMACOLOGY & THERAPEUTICS 0009-9236 1532-6535 115 2 206-212<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10079182"><a href="/gui2/?type=authors&mode=browse&sel=10079182" target="_blank">Horváth István László (<span class="authorship-author-name">Horváth István László</span> <span class="authorAux-mtmt"> gyógyszerész</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/University Pharmacy Department of Pharmacy Administration; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059913"><a href="/gui2/?type=authors&mode=browse&sel=10059913" target="_blank">Kleiner Dénes (<span class="authorship-author-name">Kleiner Dénes</span> <span class="authorAux-mtmt"> gyógyszerész</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/University Pharmacy Department of Pharmacy Administration; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081469"><a href="/gui2/?type=authors&mode=browse&sel=10081469" target="_blank">Nagy Rita (<span class="authorship-author-name">Nagy Rita</span> <span class="authorAux-mtmt"> Gyermekgyógyászat</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023284"><a href="/gui2/?type=authors&mode=browse&sel=10023284" target="_blank">Fehérvári Péter (<span class="authorship-author-name">Fehérvári Péter</span> <span class="authorAux-mtmt"> Biomatematika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Élelmiszerlánc-biztonsági és Járványvédelmi Intézet">ÉBJI</span>/<span title="Institute of Economics and Biostatistics">IEB</span>/Department of Biostatistics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020592"><a href="/gui2/?type=authors&mode=browse&sel=10020592" target="_blank">Hankó Balázs (<span class="authorship-author-name">Hankó Balázs</span> <span class="authorAux-mtmt"> gyógyszerügyi szervezéstan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Pharmacy">FP</span>/University Pharmacy Department of Pharmacy Administration</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001143"><a href="/gui2/?type=authors&mode=browse&sel=10001143" target="_blank">Csupor Dezső ✉ (<span class="authorship-author-name">Csupor Dezső</span> <span class="authorAux-mtmt"> Klinikai gyógyszerészet; Fitokémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Clinical Pharmacy; <span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34413258" target="_blank">Nafamostat Reduces the Incidence of post-ERCP Pancreatitis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials</a></div> <div> <span class="journal-title">CLINICAL PHARMACOLOGY & THERAPEUTICS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0009-9236">0009-9236</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1532-6535">1532-6535</a>)</span>: <span class="journal-volume">115</span> <span class="journal-issue">2</span> <span class="page"> pp 206-212 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1002/cpt.3118" target="_blank" href="https://doi.org/10.1002/cpt.3118"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001133868900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001133868900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85180837995" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85180837995"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38032816" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38032816&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="29392" target="_blank" href="http://publicatio.bibl.u-szeged.hu/29392"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 6 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;5 | WoS/Scopus assigned:&nbsp;6 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34413258&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34413258</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="lastModified">Last Modified: 2024.12.06. 19:06 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Export Date: 10 December 2024 CODEN: CLPTA Correspondence Address: Csupor, D.; Centre for Translational Medicine, Hungary; email: csupor.dezso@szte.hu</pre> </div></div>