https://m2.mtmt.hu/ hun 2026-10-24 15:09 JournalArticle 34411671 VALIDATED true 0 false 2026-10-24T01:33:50.448+0000 2026-03-13T12:36:59.930+0000 2023-12-02T14:24:44.380+0000 true 10013024 Molnár Gergő Attila /api/author/10013024 Author true 10013024 2026-04-24T05:30:44.493+0000 2026-04-24T05:30:44.493+0000 2024-01-09T08:01:13.995+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097590 /api/admin/10097590 Orbán Zsófia true true 2024-10-17T16:21:58.800+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Polivka, Lörinc Waning of SARS-CoV-2 Vaccine Effectiveness in COPD Patients Lessons from the Delta Variant true true /api/journal/10054162 REVIEWED true false 10054162 false 10054162 true 2076-393X Journal FOREIGN 11 12 1786 1786 12 2023 Although the COVID-19 pandemic is profoundly changing, data on the effect of vaccination and duration of protection against infection and severe disease can still be advantageous, especially for patients with COPD, who are more vulnerable to respiratory infections. The Hungarian COVID-19 registry was retrospectively investigated for risk of infection and hospitalization by time since the last vaccination, and vaccine effectiveness (VE) was calculated in adults with COPD diagnosis and an exact-matched control group during the Delta variant of concern (VOC) wave in Hungary (September–December 2021). For the matching, sex, age, major co-morbidities, vaccination status, and prior infection data were obtained on 23 August 2021. The study population included 373,962 cases divided into COPD patients (age: 66.67 ± 12.66) and a 1:1 matched group (age: 66.73 ± 12.67). In both groups, the female/male ratio was 52.2:47.7, respectively. Among the unvaccinated, there was no difference between groups in risk for infection or hospitalization. Regarding vaccinated cases, in the COPD group, a slightly faster decline in effectiveness was noted for hospitalization prevention, although in both groups, the vaccine lost its significant effect between 215 and 240 days after the last dose of vaccination. Based on a time-stratified multivariate Cox analysis of the vaccinated cases, the hazard was constantly higher in the COPD group, with an HR of 1.09 (95%: 1.05–1.14) for infection and 1.87 (95% CI: 1.59–2.19) for hospitalization. In our study, COPD patients displayed lower vaccine effectiveness against SARS-CoV-2 infection and hospitalization but a similar waning trajectory, as vaccines lost their preventive effect after 215 days. These data emphasize revaccination measures in the COPD patient population. true false 2023 true true true false true false GOLD 2026-10-24 true https://doi.org/10.3390/vaccines11121786 3 0 3 2 1 3 3 3 3 3 3 2 2 2 1 0 3 2 3 2 0 3 3 Folyóiratcikk Journal Article 24 3 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 2 1 2 1 Q1 false 10028053 false false false 2024-01-01T11:30:04.094+0000 Akadémikus bibliográfia; Amerikai úti Ideggyógyászati és Idegsebészeti I... (OMIII); II. sz. Belgyógyászati Klinika és Nephrológiai,... (PTE / ÁOK); Országos Mentális, Ideggyógyászati és Idegsebés...; Országos Onkológiai Intézet; Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Pulmonológiai Klinika (SE / AOK / K); Reumatológiai Tanszék (DE / ÁOK / BelgyI); Városmajori Szív- és Érgyógyászati Klinika (SE / AOK / K) 13 98 9 16 0 true 10097590 10067876 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 112820237 /api/authorship/112820237 1 0.0625 true false false Author 10084707 /api/author/10084707 Polivka Lőrinc true true Polivka Lörinc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112482745 /api/authorship/112482745 2 0.063 false false Author 10034838 /api/author/10034838 Vályi-Nagy István true 10034838 true Valyi-Nagy István true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112482746 /api/authorship/112482746 3 0.063 false false Author 10003464 /api/author/10003464 Szekanecz Zoltán true 10003464 true Szekanecz Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820240 /api/authorship/112820240 4 0.0625 false false false Author 10003497 /api/author/10003497 Bogos Krisztina true 10003497 true Bogos Krisztina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820241 /api/authorship/112820241 5 0.063 false false false Author 10013981 /api/author/10013981 Vágó Hajnalka true 10013981 true Vago Hajnalka true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820242 /api/authorship/112820242 6 0.0625 false false false Author 10000108 /api/author/10000108 Kamondi Anita true 10000108 true Kamondi Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820243 /api/authorship/112820243 7 0.0625 false false false Author 10043807 /api/author/10043807 Fekete Ferenc true 10043807 true Fekete Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820244 /api/authorship/112820244 8 0.0625 false false false Szlavik Janos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820245 /api/authorship/112820245 9 0.0625 false false false Author 10028053 /api/author/10028053 Surján György true 10028053 true Surjan György true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820246 /api/authorship/112820246 10 0.0625 false false false Surjan Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820247 /api/authorship/112820247 11 0.063 false false false Author 10021022 /api/author/10021022 Nagy Péter true 10021022 true Nagy Peter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820248 /api/authorship/112820248 12 0.063 false false false Author 1323309 /api/author/1323309 Schaff Zsuzsa true 1323309 true Schaff Zsuzsa true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820249 /api/authorship/112820249 13 0.0625 false false false Author 10077079 /api/author/10077079 Kiss Zoltán true true Kiss Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820250 /api/authorship/112820250 14 0.0625 false false false Müller Cecilia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820251 /api/authorship/112820251 15 0.063 false false false Author 10024576 /api/author/10024576 Kásler Miklós true 10024576 true Kasler Miklos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112820252 /api/authorship/112820252 16 0.063 false true true Author 10012282 /api/author/10012282 Müller Veronika true 10012282 true Müller Veronika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true Institute 19040 /api/institute/19040 0 false false true Akadémikus bibliográfia Bibliografy of Hungarian of Academy of Sciences' academicians true 19040 true PublicationIdentifier 25053779 /api/publicationidentifier/25053779 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/vaccines11121786 https://doi.org/10.3390/vaccines11121786 false true PublicationIdentifier 25280441 /api/publicationidentifier/25280441 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001131056200001 https://www.webofscience.com/wos/woscc/full-record/001131056200001 false true PublicationIdentifier 25247357 /api/publicationidentifier/25247357 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 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/api/ratingtype/10002 sjr true true ClassificationExternal 3002 /api/classificationexternal/3002 true 3002 true Q1 DIRECT true true /api/publication/34411671 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10084707"><a href="/gui2/?type=authors&mode=browse&sel=10084707" target="_blank">Polivka Lörinc (<span class="authorship-author-name">Polivka Lőrinc</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034838"><a href="/gui2/?type=authors&mode=browse&sel=10034838" target="_blank">Valyi-Nagy István (<span class="authorship-author-name">Vályi-Nagy István</span> <span class="authorAux-mtmt"> Hematológia, belgyógyászat, onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003464"><a href="/gui2/?type=authors&mode=browse&sel=10003464" target="_blank">Szekanecz Zoltan (<span class="authorship-author-name">Szekanecz Zoltán</span> <span class="authorAux-mtmt"> Reumatológia</span>) </a> </span> <span class="author-affil"><span title="Debreceni Egyetem">DE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/<span title="Belgyógyászati Intézet">BelgyI</span>/Reumatológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003497"><a href="/gui2/?type=authors&mode=browse&sel=10003497" target="_blank">Bogos Krisztina (<span class="authorship-author-name">Bogos Krisztina</span> <span class="authorAux-mtmt"> Tüdőgyógyászat, Klinikai Onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013981"><a href="/gui2/?type=authors&mode=browse&sel=10013981" target="_blank">Vago Hajnalka (<span class="authorship-author-name">Vágó Hajnalka</span> <span class="authorAux-mtmt"> Kardiológia, MR</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Városmajori Szív- és Érgyógyászati Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000108"><a href="/gui2/?type=authors&mode=browse&sel=10000108" target="_blank">Kamondi Anita (<span class="authorship-author-name">Kamondi Anita</span> <span class="authorAux-mtmt"> Idegtudományok</span>) </a> </span> <span class="author-affil">Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet; <span title="Országos Mentális, Ideggyógyászati és Idegsebészeti Intézet">OMIII</span>/Amerikai úti Ideggyógyászati és Idegsebészeti Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043807"><a href="/gui2/?type=authors&mode=browse&sel=10043807" target="_blank">Fekete Ferenc (<span class="authorship-author-name">Fekete Ferenc</span> <span class="authorAux-mtmt"> csecsemő és gyermekgyógyász</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szlavik Janos </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028053"><a href="/gui2/?type=authors&mode=browse&sel=10028053" target="_blank">Surjan György (<span class="authorship-author-name">Surján György</span> <span class="authorAux-mtmt"> Orvosi informatika</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Surjan Orsolya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10021022"><a href="/gui2/?type=authors&mode=browse&sel=10021022" target="_blank">Nagy Peter (<span class="authorship-author-name">Nagy Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1323309"><a href="/gui2/?type=authors&mode=browse&sel=1323309" target="_blank">Schaff Zsuzsa (<span class="authorship-author-name">Schaff Zsuzsa</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077079"><a href="/gui2/?type=authors&mode=browse&sel=10077079" target="_blank">Kiss Zoltan (<span class="authorship-author-name">Kiss Zoltán</span> <span class="authorAux-mtmt"> A főbb mortalitásért felelős betegségek epidemi...</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/II. sz. Belgyógyászati Klinika és Nephrológiai, Diabetológiai Centrum</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Müller Cecilia </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024576"><a href="/gui2/?type=authors&mode=browse&sel=10024576" target="_blank">Kasler Miklos (<span class="authorship-author-name">Kásler Miklós</span> <span class="authorAux-mtmt"> Klinikai onkológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012282"><a href="/gui2/?type=authors&mode=browse&sel=10012282" target="_blank">Müller Veronika ✉ (<span class="authorship-author-name">Müller Veronika</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pulmonológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34411671" target="_blank">Waning of SARS-CoV-2 Vaccine Effectiveness in COPD Patients : Lessons from the Delta Variant.</a></div> <div> <span class="journal-title">VACCINES (BASEL)</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2076-393X">2076-393X</a>)</span>: <span class="journal-volume">11</span> <span class="journal-issue">12</span> <span class="page"> Paper 1786. 12 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/vaccines11121786" target="_blank" href="https://doi.org/10.3390/vaccines11121786"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001131056200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001131056200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85180662724" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85180662724"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38140190" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38140190&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Infectious Diseases&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 3</span> | Független: 2 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 3 | Scopus jelölt:&nbsp;3 | WoS/Scopus jelölt:&nbsp;3 | DOI jelölt:&nbsp;3 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34411671&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34411671</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="special-affiliations"> Speciális affiliáció: Akadémikus bibliográfia </div> <div class="lastModified">Utolsó módosítás: 2026.03.13. 13:36 Surján György (Orvosi informatika) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:21 Ladányi Gusztáv (MTMT API user, admin) Orbán Zsófia (MTMT ellenőrzés, admin) </div> </div></div>