https://m2.mtmt.hu/ eng 2026-05-31 01:50 JournalArticle 34410493 VALIDATED true Cited By :1 Export Date: 1 December 2024 Correspondence Address: Ács, L.; Department of Paediatric Dentistry and Orthodontics, Szentkirályi u. 47, Hungary; email: acslili18@gmail.com 0 false 2026-05-23T10:10:34.173+0000 2024-08-30T07:41:43.301+0000 2023-12-01T12:58:04.120+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true 2026-05-04T13:10:12.931+0000 2026-05-04T13:10:12.931+0000 2024-08-30T07:41:43.581+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Ács, Lili Maternal factors in the origin of cleft lip/cleft palate: A population-based case–control study true true /api/journal/10011772 REVIEWED true false 10011772 false 10011772 true 1601-6335 1601-6343 Journal 27 S1 6 13 6 8 2024 Abstract Objectives Orofacial clefts are among the most common birth defects, with an estimated worldwide incidence of around 1.5-1.7 per 1000 live-born babies. The most frequent form of orofacial clefts is cleft lip with or without cleft palate (CL?±?CP). The role of environmental factors in the development of clefts is unclear in most patients, thus the aim of this study was to estimate possible maternal risk factors in the origin of CL?±?CP. Materials and Methods 1648 CL?±?CP cases, 2654 matched controls and 57?231 population controls were evaluated from The Hungarian Case?Control Surveillance of Congenital Abnormalities. Maternal factors during the critical period in cases and controls were compared. Adjusted odds ratios (OR) with 95% confidence intervals (CI) were estimated in a multivariable conditional logistic regression model. Results Among socio-demographic data, we have found significant differences between maternal employment. The proportion of unskilled mothers (6.5%) were higher in the CL?±?CP group than in controls (3.5%). Medically recorded maternal anaemia, excessive vomiting and threatened abortion were associated with a higher risk of CL?±?CP. An elevated risk was also found in various acute illnesses such as influenza (OR: 2.4, 95% CI: 3.0-5.8), acute bronchitis (OR: 4.5, 95% CI: 1.6-12.6) and urinary tract infections (OR: 3.5, 95% CI: 2.0-6.0). Maternal migraine and essential hypertension occurred more frequently in the mothers of cases than in controls. Conclusion The findings of this study suggest that maternal diseases and lifestyle factors during the first trimester play a significant role in the development of CL?±?CP. true 2023 true true true false true false NONE 2026-05-23 false 6 0 6 5 1 6 6 5 4 6 6 5 5 5 1 0 6 5 6 5 0 9 9 Folyóiratcikk Journal Article 24 6 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 2025 0 3 2 3 2 2026 0 2 2 2 2 Q1 false false false false 2024-02-29T13:01:03.963+0000 Arc- Állcsont- Szájsebészeti és Fogászati Klinika (SE / FOK); Gyermekfogászati és Fogszabályozási Klinika (SE / FOK); Gyermekgyógyászati Klinika (SE / AOK / K); Szülészeti és Nőgyógyászati Klinika (SE / AOK / K); Transzlációs Medicina Központ (SE / KSZE) 6 28 5 6 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 112759521 /api/authorship/112759521 1 0.167 true false true Author 10071870 /api/author/10071870 Ács Lili Judit true true Ács Lili true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112759522 /api/authorship/112759522 2 0.167 false false false Author 10045604 /api/author/10045604 Nemes Bálint true 10045604 true Nemes Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112759523 /api/authorship/112759523 3 0.167 false false false Author 10034000 /api/author/10034000 Nagy Krisztián true 10034000 true Nagy Krisztián true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112759524 /api/authorship/112759524 4 0.167 false false false Author 10092848 /api/author/10092848 Ács Márton true true Ács Márton true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112759525 /api/authorship/112759525 5 0.167 false false false Author 10009719 /api/author/10009719 Bánhidy Ferenc true 10009719 true Bánhidy Ferenc true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112759526 /api/authorship/112759526 6 0.167 false true false Author 10014005 /api/author/10014005 Rózsa Noémi Katinka true 10014005 true Rózsa Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 25051614 /api/publicationidentifier/25051614 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true NONE IDENTICAL 10.1111/ocr.12738 https://doi.org/10.1111/ocr.12738 false true PublicationIdentifier 25105355 /api/publicationidentifier/25105355 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001108877900001 https://www.webofscience.com/wos/woscc/full-record/001108877900001 true true PublicationIdentifier 25091364 /api/publicationidentifier/25091364 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85177764320 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85177764320 false true PublicationIdentifier 25105363 /api/publicationidentifier/25105363 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 38010849 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38010849&dopt=Abstract true true Keyword 6820 /api/keyword/6820 true 6820 true Keyword 1035827 /api/keyword/1035827 true 1035827 true Keyword 1035828 /api/keyword/1035828 true 1035828 true Keyword 1736712 /api/keyword/1736712 true true Keyword 1791928 /api/keyword/1791928 true true SjrRating 11489279 /api/sjrrating/11489279 12 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 3504 /api/classificationexternal/3504 true 3504 true Q1 DIRECT true true /api/publication/34410493 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071870"><a href="/gui2/?type=authors&mode=browse&sel=10071870" target="_blank">Ács Lili ✉ (<span class="authorship-author-name">Ács Lili Judit</span> <span class="authorAux-mtmt"> gyermekfogászat, fogszabályozás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Pedodontics and Orthodontics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10045604"><a href="/gui2/?type=authors&mode=browse&sel=10045604" target="_blank">Nemes Bálint (<span class="authorship-author-name">Nemes Bálint</span> <span class="authorAux-mtmt"> Fogorvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Pedodontics and Orthodontics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10034000"><a href="/gui2/?type=authors&mode=browse&sel=10034000" target="_blank">Nagy Krisztián (<span class="authorship-author-name">Nagy Krisztián</span> <span class="authorAux-mtmt"> arc- és állcsontsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Pediatrics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10092848"><a href="/gui2/?type=authors&mode=browse&sel=10092848" target="_blank">Ács Márton (<span class="authorship-author-name">Ács Márton</span> <span class="authorAux-mtmt"> Szájsebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Oro-Maxillofacial Surgery and Stomatology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009719"><a href="/gui2/?type=authors&mode=browse&sel=10009719" target="_blank">Bánhidy Ferenc (<span class="authorship-author-name">Bánhidy Ferenc</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Obsterics and Gynecology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014005"><a href="/gui2/?type=authors&mode=browse&sel=10014005" target="_blank">Rózsa Noémi (<span class="authorship-author-name">Rózsa Noémi Katinka</span> <span class="authorAux-mtmt"> Gyermekfogászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Dentistry">FD</span>/Department of Pedodontics and Orthodontics</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34410493" target="_blank">Maternal factors in the origin of cleft lip/cleft palate: A population-based case–control study</a></div> <div> <span class="journal-title">ORTHODONTICS & CRANIOFACIAL RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1601-6335">1601-6335</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1601-6343">1601-6343</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">S1</span> <span class="page"> pp 6-13 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="10.1111/ocr.12738" target="_blank" href="https://doi.org/10.1111/ocr.12738"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001108877900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001108877900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85177764320" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85177764320"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="38010849" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=38010849&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Oral Surgery&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Orthodontics&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Otorhinolaryngology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Surgery&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 6</span> | Independent citation: 5 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 5 | Number of citations in Scopus:&nbsp;4 | WoS/Scopus assigned:&nbsp;6 | Number of citations with DOI:&nbsp;6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34410493&sort=publishedYear,desc&sort=title"> Number of cited publications: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34410493</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="lastModified">Last Modified: 2024.08.30. 09:41 Tamásné Gere (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Cited By :1 Export Date: 1 December 2024 Correspondence Address: Ács, L.; Department of Paediatric Dentistry and Orthodontics, Szentkirályi u. 47, Hungary; email: acslili18@gmail.com</pre> </div></div>