https://m2.mtmt.hu/ hun 2026-09-21 18:30 JournalArticle 34409947 VALIDATED true Institute of Genetics, HUN-REN Biological Research Centre, Temesvári krt. 62, Szeged, H-6726, Hungary Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary Aktogen Hungary Ltd., Szeged, H-6726, Hungary Institute of Biochemistry, HUN-REN Biological Research Centre, Szeged, H-6726, Hungary Department of Genetics, University of Szeged, Szeged, H-6726, Hungary Export Date: 6 March 2024 CODEN: DEVPE Correspondence Address: Mihály, J.; Institute of Genetics, Temesvári krt. 62, Hungary; email: mihaly.jozsef@brc.hu 0 false 2026-05-23T10:09:05.249+0000 2024-03-31T15:57:36.203+0000 2023-12-01T08:59:50.082+0000 true 10045852 Patkósné Hanesz Andrea /api/admin/10045852 Admin true 10045852 2025-09-05T07:09:32.101+0000 2024-03-31T15:57:36.539+0000 true 10018695 Bernátskyné Babus Csilla /api/admin/10018695 Admin true 10018695 Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-04-03T13:48:21.583+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Gazsó-Gerhát, Gabriella FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor true true /api/journal/1302 REVIEWED true false 1302 false 1302 true 0950-1991 1477-9129 Journal FOREIGN 150 22 dev.201713 dev.201713 13 2023 Optical insulation of the unit eyes (ommatidia) is an important prerequisite of precise sight with compound eyes. Separation of the ommatidia is ensured by pigment cells that organize into a hexagonal lattice in the Drosophila eye, forming thin walls between the facets. Cell adhesion, mediated by apically and latero-basally located junctional complexes, is crucial for stable attachment of these cells to each other and the basal lamina. Whereas former studies have focused on the formation and remodelling of the cellular connections at the apical region, here, we report a specific alteration of the lateral adhesion of the lattice cells, leaving the apical junctions largely unaffected. We found that DAAM and FRL, two formin-type cytoskeleton regulatory proteins, play redundant roles in lateral adhesion of the interommatidial cells and patterning of the retinal floor. We show that formin-dependent cortical actin assembly is crucial for latero-basal sealing of the ommatidial lattice. 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title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Biológia Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024995"><a href="/gui2/?type=authors&mode=browse&sel=10024995" target="_blank">Gombos Rita<sup>*</sup> (<span class="authorship-author-name">Gombos Rita I</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061189"><a href="/gui2/?type=authors&mode=browse&sel=10061189" target="_blank">Tóth Krisztina (<span class="authorship-author-name">Tóth Krisztina</span> <span class="authorAux-mtmt"> molekuláris biológia, genetika</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10062327"><a href="/gui2/?type=authors&mode=browse&sel=10062327" target="_blank">Kaltenecker Péter (<span class="authorship-author-name">Kaltenecker Péter</span> <span class="authorAux-mtmt"> fejlődésgenetika</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10030426"><a href="/gui2/?type=authors&mode=browse&sel=10030426" target="_blank">Szikora Szilárd (<span class="authorship-author-name">Szikora Szilárd</span> <span class="authorAux-mtmt"> Biológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024913"><a href="/gui2/?type=authors&mode=browse&sel=10024913" target="_blank">Bíró Judit (<span class="authorship-author-name">Bíró Judit</span> <span class="authorAux-mtmt"> növénybiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Csapó Enikő </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027867"><a href="/gui2/?type=authors&mode=browse&sel=10027867" target="_blank">Asztalos Zoltán (<span class="authorship-author-name">Asztalos Zoltán Imre</span> <span class="authorAux-mtmt"> biokémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Biokémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010519"><a href="/gui2/?type=authors&mode=browse&sel=10010519" target="_blank">Mihály József ✉ (<span class="authorship-author-name">Mihály József</span> <span class="authorAux-mtmt"> genetika</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Biológia Intézet">BI</span>/Genetikai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34409947" target="_blank">FRL and DAAM are required for lateral adhesion of interommatidial cells and patterning of the retinal floor</a></div> <div> <span class="journal-title">DEVELOPMENT</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0950-1991">0950-1991</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1477-9129">1477-9129</a>)</span>: <span class="journal-volume">150</span> <span class="journal-issue">22</span> <span class="page"> Paper dev.201713. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1242/dev.201713" target="_blank" href="https://doi.org/10.1242/dev.201713"> DOI </a> </span> <span class="id identifier oa_none" title="none"> 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href="https://journals.biologists.com/dev/article/150/22/dev201713/335492/FRL-and-DAAM-are-required-for-lateral-adhesion-of"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="34610" target="_blank" href="http://publicatio.bibl.u-szeged.hu/34610"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Developmental Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 1 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 2 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34409947&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34409947</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2024.03.31. 17:57 Bernátskyné Babus Csilla (SZTE admin4) </div> <div class="lockedBy">Központi kezelésű 2024.04.03. 15:48 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Institute of Genetics, HUN-REN Biological Research Centre, Temesvári krt. 62, Szeged, H-6726, Hungary Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, Szeged, H-6726, Hungary Aktogen Hungary Ltd., Szeged, H-6726, Hungary Institute of Biochemistry, HUN-REN Biological Research Centre, Szeg...</pre> </div></div>