(TKP2021-NVA-19) Támogató: Innovációs és Technológiai Minisztérium
(NKFIH K 146733)
(NAP2022-I-6/2022)
LP(LP2020-5/2020) Támogató: MTA
(ÚNKP-23-3)
Szakterületek:
Analitikai kémia
Kémiai tudományok
Spektroszkópia
Spektroszkópiai és spektrometriai technikák
Természettudományok
Tudomány
Commonly used sample introduction systems for inductively coupled plasma mass spectrometry
(ICP-MS) are generally not well-suited for single particle ICP-MS (spICP-MS) applications
due to their high sample requirements and low efficiency. In this study, the first
completely 3D-printed, polymer SIS was developed to facilitate spICP-MS analysis.
The system is based on a microconcentric pneumatic nebulizer and a single-pass spray
chamber with an additional sheath gas flow to further facilitate the transport of
larger droplets or particles. The geometry of the system was optimized using numerical
simulations. Its aerosol characteristics and operational conditions were studied via
optical particle counting and a course of spICP-MS measurements, involving nanodispersions
and cell suspensions. In a comparison of the performance of the new and the standard
(quartz microconcentric nebulizer plus a double-pass spray chamber) systems, it was
found that the new sample introduction system has four times higher particle detection
efficiency, significantly better signal-to-noise ratio, provides ca. 20% lower size
detection limit, and allows an extension of the upper limit of transportable particle
diameters to about 25 µm.
