https://m2.mtmt.hu/ hun 2026-09-22 03:07 JournalArticle 34393532 VALIDATED true 0 false 2026-07-21T10:25:18.159+0000 2025-07-09T12:13:38.157+0000 2023-11-21T19:51:35.151+0000 true 10065394 Fésűs Luca /api/admin/10065394 Admin Fésűs Luca (SE_AOK_Bőr-, Nemikórtani és Bőronkológiai Klinika_Admin5_FL, admin) false 2025-07-09T12:13:20.966+0000 2025-07-09T12:13:20.966+0000 2025-07-09T12:13:38.409+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin Gere Tamásné (SE_KK_Admin5_GT, admin) true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Bozsányi, Szabolcs true true /api/journal/10017543 REVIEWED JOURNAL OF CLINICAL MEDICINE 2077-0383 true false 10017543 false 10017543 true 2077-0383 Journal FOREIGN 12 21 6910 6910 14 2023 Background: Basal cell carcinoma (BCC) is the most common type of skin cancer in the Caucasian population. Currently, invasive biopsy is the only way of establishing the histological subtype (HST) that determines the treatment options. Our study aimed to evaluate whether optically guided high-frequency ultrasound (OG-HFUS) imaging could differentiate aggressive HST BCCs from low-risk tumors. Methods: We conducted prospective clinical and dermoscopic examinations of BCCs, followed by 33 MHz OG-HFUS imaging, surgical excision, and a histological analysis. We enrolled 75 patients with 78 BCCs. In total, 63 BCCs were utilized to establish a novel OG-HFUS risk classification algorithm, while 15 were employed for the validation of this algorithm. The mean age of the patients was 72.9 ± 11.2 years. Histology identified 16 lesions as aggressive HST (infiltrative or micronodular subtypes) and 47 as low-risk HST (superficial or nodular subtypes). To assess the data, we used a one-sided Fisher’s exact test for a categorical analysis and a Receiver Operating Characteristic (ROC) curve analysis to evaluate the diagnostic accuracy. Results: OG-HFUS distinguished aggressive BCC HSTs by their irregular shape (p < 0.0001), ill-defined margins (p < 0.0001), and non-homogeneous internal echoes (p = 0.004). We developed a risk-categorizing algorithm that differentiated aggressive HSTs from low-risk HSTs with a higher sensitivity (82.4%) and specificity (91.3%) than a combined macroscopic and dermoscopic evaluation (sensitivity: 40.1% and specificity: 73.1%). The positive and negative predictive values (PPV and NPV, respectively) for dermoscopy were 30.2% and 76.8%, respectively. In comparison, the OG-HFUS-based algorithm demonstrated a PPV of 94.7% and an NPV of 78.6%. We verified the algorithm using an independent image set, n = 15, including 12 low-risk and 3 high-risk (high-risk) with two blinded evaluators, where we found a sensitivity of 83.33% and specificity of 91.66%. Conclusions: Our study shows that OG-HFUS can identify aggressive BCC HSTs based on easily identifiable morphological parameters, supporting early therapeutic decision making. Funding 2033870 /api/funding/2033870 Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP false true Funding 2033871 /api/funding/2033871 (ÚNKP-23-4-II-SE-8) false true Funding 2033872 /api/funding/2033872 (ÚNKP-22-2-III-SE-18) false true true 2023 true true true false true false GOLD 2026-07-21 false http://www.mdpi.com/journal/jcm 17 0 17 4 9 16 17 17 11 17 17 4 4 4 13 0 17 4 17 4 0 1 1 Folyóiratcikk Journal Article 24 15 Könyvrészlet Chapter in Book 25 2 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 4 1 4 1 2025 0 5 2 5 2 2026 0 8 1 8 1 Q1 false 10079444 false false false 2023-11-27T12:45:57.926+0000 Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 12 24 1 15 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 112343372 /api/authorship/112343372 Bozsányi, Szabolcs [Bozsányi, Szabolcs (Bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 1 0.067 true false false Author 10070590 /api/author/10070590 Bozsányi Szabolcs (Bőrgyógyászat) Bozsányi Szabolcs true true Bozsányi Szabolcs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343373 /api/authorship/112343373 Boostani, Mehdi* [Boostani, Mehdi (New imaging techn...), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 2 0.067 true false false Author 10093995 /api/author/10093995 Boostani Mehdi (New imaging techniques for the diagnosis of skin tumours) Boostani Mehdi true true Boostani Mehdi true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343374 /api/authorship/112343374 Farkas, Klára [Farkas, Klára Zsuzsanna (Bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 3 0.067 false false false Author 10075104 /api/author/10075104 Farkas Klára Zsuzsanna (Bőrgyógyászat) Farkas Klára Zsuzsanna true true Farkas Klára true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343375 /api/authorship/112343375 Hamilton-Meikle, Phyllida [Hamilton-Meikle, Phyllida Kerstin (Bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 4 0.067 false false false Author 10089196 /api/author/10089196 Hamilton-Meikle Phyllida Kerstin (Bőrgyógyászat) Hamilton-Meikle Phyllida Kerstin true true Hamilton-Meikle Phyllida true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343376 /api/authorship/112343376 Varga, Noémi Nóra [Varga, Noémi (Orvosi tudományok), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 5 0.067 false false false Author 10080617 /api/author/10080617 Varga Noémi (Orvosi tudományok) Varga Noémi true true Varga Noémi Nóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343377 /api/authorship/112343377 Szabó, Boglárka 6 0.06666667 false false false Szabó Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343378 /api/authorship/112343378 Vasanits, Flóra 7 0.06666667 false false false Vasanits Flóra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343379 /api/authorship/112343379 Kuroli, Enikő [Kuroli, Enikő (bőrgyógyászat, pa...), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 8 0.067 false false false Author 10069048 /api/author/10069048 Kuroli Enikő (bőrgyógyászat, patológia) Kuroli Enikő true true Kuroli Enikő true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343380 /api/authorship/112343380 Meznerics, Fanni Adél [Meznerics, Fanni Adél (Bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 9 0.067 false false false Author 10079444 /api/author/10079444 Meznerics Fanni Adél (Bőrgyógyászat) Meznerics Fanni Adél true true Meznerics Fanni Adél true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343381 /api/authorship/112343381 Lőrincz, Kende [Lőrincz, Kende Kálmán (Bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 10 0.067 false false false Author 10038409 /api/author/10038409 Lőrincz Kende Kálmán (Bőrgyógyászat) Lőrincz Kende Kálmán true 10038409 true Lőrincz Kende true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343382 /api/authorship/112343382 Holló, Péter [Holló, Péter (Bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 11 0.067 false false false Author 10019467 /api/author/10019467 Holló Péter (Bőrgyógyászat) Holló Péter true 10019467 true Holló Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343383 /api/authorship/112343383 Bánvölgyi, András [Bánvölgyi, András (bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 12 0.067 false false false Author 10037621 /api/author/10037621 Bánvölgyi András (bőrgyógyászat) Bánvölgyi András true 10037621 true Bánvölgyi András true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 112343384 /api/authorship/112343384 Wikonkál, Norbert M. 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(2023) JOURNAL OF CLINICAL MEDICINE 2077-0383 12 21<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10070590"><a href="/gui2/?type=authors&mode=browse&sel=10070590" target="_blank">Bozsányi Szabolcs (<span class="authorship-author-name">Bozsányi Szabolcs</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10093995"><a href="/gui2/?type=authors&mode=browse&sel=10093995" target="_blank">Boostani Mehdi^* (<span class="authorship-author-name">Boostani Mehdi</span> <span class="authorAux-mtmt"> New imaging techniques for the diagnosis of ski...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10075104"><a href="/gui2/?type=authors&mode=browse&sel=10075104" target="_blank">Farkas Klára (<span class="authorship-author-name">Farkas Klára Zsuzsanna</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10089196"><a href="/gui2/?type=authors&mode=browse&sel=10089196" target="_blank">Hamilton-Meikle Phyllida (<span class="authorship-author-name">Hamilton-Meikle Phyllida Kerstin</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10080617"><a href="/gui2/?type=authors&mode=browse&sel=10080617" target="_blank">Varga Noémi Nóra (<span class="authorship-author-name">Varga Noémi</span> <span class="authorAux-mtmt"> Orvosi tudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szabó Boglárka </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Vasanits Flóra </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069048"><a href="/gui2/?type=authors&mode=browse&sel=10069048" target="_blank">Kuroli Enikő (<span class="authorship-author-name">Kuroli Enikő</span> <span class="authorAux-mtmt"> bőrgyógyászat, patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10079444"><a href="/gui2/?type=authors&mode=browse&sel=10079444" target="_blank">Meznerics Fanni Adél (<span class="authorship-author-name">Meznerics Fanni Adél</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10038409"><a href="/gui2/?type=authors&mode=browse&sel=10038409" target="_blank">Lőrincz Kende (<span class="authorship-author-name">Lőrincz Kende Kálmán</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10019467"><a href="/gui2/?type=authors&mode=browse&sel=10019467" target="_blank">Holló Péter (<span class="authorship-author-name">Holló Péter</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10037621"><a href="/gui2/?type=authors&mode=browse&sel=10037621" target="_blank">Bánvölgyi András (<span class="authorship-author-name">Bánvölgyi András</span> <span class="authorAux-mtmt"> bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002438"><a href="/gui2/?type=authors&mode=browse&sel=10002438" target="_blank">Wikonkál Norbert M. (<span class="authorship-author-name">Wikonkál Norbert</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Paragh György </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054754"><a href="/gui2/?type=authors&mode=browse&sel=10054754" target="_blank">Kiss Norbert ✉ (<span class="authorship-author-name">Kiss Norbert</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34393532" target="_blank">Optically Guided High-Frequency Ultrasound to Differentiate High-Risk Basal Cell Carcinoma Subtypes: A Single-Centre Prospective Study</a></div> <div> <span class="journal-title">JOURNAL OF CLINICAL MEDICINE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0383">2077-0383</a>)</span>: <span class="journal-volume">12</span> <span class="journal-issue">21</span> <span class="page"> Paper 6910. 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/jcm12216910" target="_blank" href="https://doi.org/10.3390/jcm12216910"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001103347000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001103347000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85176555926" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85176555926"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37959375" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37959375&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 17</span> | Független: 4 | Függő: 13 | Nem jelölt: 0 | WoS jelölt: 17 | Scopus jelölt:&nbsp;11 | WoS/Scopus jelölt:&nbsp;17 | DOI jelölt:&nbsp;17 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34393532&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34393532</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, (ÚNKP-23-4-II-SE-8), (ÚNKP-22-2-III-SE-18) </div> <div class="lastModified">Utolsó módosítás: 2025.07.09. 14:13 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> </div></div>