https://m2.mtmt.hu/ eng 2026-10-25 00:04 JournalArticle 34379986 ADMIN_APPROVED true Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria National Koranyi Institute of Pulmonology, Budapest, Hungary Division of Pulmonology, Department of Medicine II, Medical University of Vienna, Austria Department of Thoracic Surgery, Semmelweis University, National Institute of Oncology, Budapest, Hungary Center for Cancer Research, Medical University Vienna, Vienna, Austria Institute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary Department of Biomedical Engineering, Lund University, Lund, Sweden Department of Translational Medicine, Lund University, Lund, Sweden Export Date: 22 January 2024 CODEN: CCREF Correspondence Address: Dome, B.; Department of Thoracic Surgery, Waehringer Guertel 18-20, Austria; email: balazs.dome@meduniwien.ac.at Correspondence Address: Schelch, K.; Department of Thoracic Surgery, Waehringer Guertel 18-20, Austria; email: karin.schelch@meduniwien.ac.at Chemicals/CAS: carboplatin, 41575-94-4; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; entinostat, 209783-80-2; epirubicin, 56390-09-1, 56420-45-2; etoposide, 33419-42-0, 433304-61-1; irinotecan, 100286-90-6, 97682-44-5; Cisplatin; entinostat; Histone Deacetylase Inhibitors Manufacturers: Accord Healthcare; MedChemexpress; Teva 0 false 2026-10-24T00:51:41.750+0000 2026-02-25T10:23:30.741+0000 2023-11-20T14:16:09.093+0000 true 10070075 Nádas Orsolya /api/admin/10070075 Admin true 2026-04-20T10:45:09.658+0000 2026-04-20T10:45:09.658+0000 2025-01-28T10:57:12.453+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Solta, Anna Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair. true true /api/journal/1405637 REVIEWED true false 1405637 false 1405637 true 1078-0432 1557-3265 Journal FOREIGN 29 22 4644 4659 4644 16 2023 Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC), one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. Accordingly, we aimed to investigate the dual targeting of HDAC inhibition and chemotherapy in SCLC.The efficacy of HDACi and chemotherapy in SCLC was investigated both in vitro and in vivo. Synergistic drug interactions were calculated based on the HSA model (Combenefit software). Results from the proteomic analysis were confirmed via ICP-MS, cell-cycle analysis, and comet assays.Single entinostat- or chemotherapy significantly reduced cell viability in human neuroendocrine SCLC cells. The combination of entinostat with either cisplatin, carboplatin, irinotecan, epirubicin, or etoposide led to strong synergy in a subset of resistant SCLC cells. Combination treatment with entinostat and cisplatin significantly decreased tumor growth in vivo. Proteomic analysis comparing the groups of SCLC cell lines with synergistic and additive response patterns indicated alterations in cell-cycle regulation and DNA damage repair. Cell-cycle analysis revealed that cells exhibiting synergistic drug responses displayed a shift from G1 to S-phase compared with cells showing additive features upon dual treatment. Comet assays demonstrated more DNA damage and decreased base excision repair in SCLC cells more responsive to combination therapy.In this study, we decipher the molecular processes behind synergistic interactions between chemotherapy and HDAC inhibition. Moreover, we report novel mechanisms to overcome drug resistance in SCLC, which may be relevant to increasing therapeutic success. Funding 2033502 /api/funding/2033502 false true Funding 2033503 /api/funding/2033503 false true Funding 2033504 /api/funding/2033504 false true Funding 2033505 /api/funding/2033505 false true Funding 2033506 /api/funding/2033506 false true Funding 2033507 /api/funding/2033507 false true Funding 2033508 /api/funding/2033508 false true Funding 2033509 /api/funding/2033509 false true Funding 2033510 /api/funding/2033510 false true Funding 2033511 /api/funding/2033511 false true true INTERNATIONAL 2023 true true true false true false NONE 2026-10-24 false 32 0 32 30 2 32 30 31 29 32 32 30 30 30 2 0 32 30 32 30 0 7 7 Folyóiratcikk Journal Article 24 32 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 7 7 7 7 2025 0 14 12 14 12 2026 0 10 10 10 10 D1 false 10000046 false false false 2023-11-27T09:17:31.595+0000 Belgyógyászati és Onkológiai Klinika (SE / AOK / K); Mellkassebészeti Klinika (SE / AOK / K); Országos Korányi Pulmonológiai Intézet; Országos Onkológiai Intézet 4 18 4 16 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 112262180 /api/authorship/112262180 1 0.0625 true false false Solta Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112262181 /api/authorship/112262181 2 0.0625 false false false Boettiger Kristiina true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112262182 /api/authorship/112262182 3 0.0625 false false false Author 10058741 /api/author/10058741 Kovács Ildikó true 10058741 true Kovács Ildikó true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112262183 /api/authorship/112262183 4 0.0625 false false false Lang Christian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112262184 /api/authorship/112262184 5 0.063 false false false Author 10071898 /api/author/10071898 Megyesfalvi Zsolt true true Megyesfalvi Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112262185 /api/authorship/112262185 6 0.0625 false false false Ferk Franziska true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112262186 /api/authorship/112262186 7 0.0625 false false false Mišík Miroslav 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112262192 /api/authorship/112262192 13 0.063 false false false Author 10074938 /api/author/10074938 Szeitz Beáta true true Szeitz Beáta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112262193 /api/authorship/112262193 14 0.0625 false false false Rezeli Melinda true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112262194 /api/authorship/112262194 15 0.063 false true true Author 10000046 /api/author/10000046 Döme Balázs true 10000046 true Dome Balazs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112262195 /api/authorship/112262195 16 0.063 false true true Schelch Karin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24971891 /api/publicationidentifier/24971891 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI 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/api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37725585 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37725585&dopt=Abstract false true Classification 12215 /api/classification/12215 true true SjrRating 11360634 /api/sjrrating/11360634 15 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1306 /api/classificationexternal/1306 true 1306 true D1 DIRECT true true /api/publication/34379986 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Solta Anna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Boettiger Kristiina </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10058741"><a href="/gui2/?type=authors&mode=browse&sel=10058741" target="_blank">Kovács Ildikó (<span class="authorship-author-name">Kovács Ildikó</span> <span class="authorAux-mtmt"> Tumorbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lang Christian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071898"><a href="/gui2/?type=authors&mode=browse&sel=10071898" target="_blank">Megyesfalvi Zsolt (<span class="authorship-author-name">Megyesfalvi Zsolt</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ferk Franziska </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mišík Miroslav </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hoetzenecker Konrad </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Aigner Clemens </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kowol Christian R </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Knasmueller Siegfried </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Grusch Michael </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074938"><a href="/gui2/?type=authors&mode=browse&sel=10074938" target="_blank">Szeitz Beáta (<span class="authorship-author-name">Szeitz Beáta</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Internal Medicine and Oncology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Rezeli Melinda </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000046"><a href="/gui2/?type=authors&mode=browse&sel=10000046" target="_blank">Dome Balazs<sup>**</sup> ✉ (<span class="authorship-author-name">Döme Balázs</span> <span class="authorAux-mtmt"> Tumor indukált angiogenezis</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery; Koranyi National Institute for Pulmonology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schelch Karin ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34379986" target="_blank">Entinostat Enhances the Efficacy of Chemotherapy in Small Cell Lung Cancer Through S-phase Arrest and Decreased Base Excision Repair.</a></div> <div> <span class="journal-title">CLINICAL CANCER RESEARCH</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1078-0432">1078-0432</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1557-3265">1557-3265</a>)</span>: <span class="journal-volume">29</span> <span class="journal-issue">22</span> <span class="page"> pp 4644-4659 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1158/1078-0432.CCR-23-1795" target="_blank" href="https://doi.org/10.1158/1078-0432.CCR-23-1795"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001124136900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001124136900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85177102503" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85177102503"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37725585" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37725585&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 32</span> | Independent citation: 30 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 31 | Number of citations in Scopus:&nbsp;29 | WoS/Scopus assigned:&nbsp;32 | Number of citations with DOI:&nbsp;30 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34379986&sort=publishedYear,desc&sort=title"> Number of cited publications: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34379986</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (KH130356), (KKP126790), (2020-1.1.6-JOVO), (TKP2021-EGA-33), (Hungarian Respiratory Society (MPA #2020)), (ÚNKP-20-3), (UNKP-21-3), (János Bolyai Research Scholarship), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP, (ÚNKP-22–3-II) </div> <div class="lastModified">Last Modified: 2026.02.25. 11:23 Cecilia Laczik (SE_AOK_1Patológia_Admin5_LC, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria National Koranyi Institute of Pulmonology, Budapest, Hungary Division of Pulmonology, Department of Medicine II, Medical University of Vienna, Austria Department of Thoracic Surgery, Semmelweis University, National Ins...</pre> </div></div>