https://m2.mtmt.hu/ hun 2026-05-26 01:49 JournalArticle 34371433 VALIDATED true 0 false 2026-05-23T09:30:52.425+0000 2024-04-17T15:13:50.844+0000 2023-11-19T17:43:54.837+0000 true 10082843 Berhidi Anna /api/admin/10082843 Admin true 2026-05-21T09:13:16.107+0000 2026-05-21T09:13:16.107+0000 2024-04-17T15:13:51.441+0000 true 10025544 Lévayné Deseő Katalin /api/admin/10025544 Admin true 10025544 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2024-04-17T15:13:58.682+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Benke, Márton MiR-200b categorizes patients into pancreas cystic lesion subgroups with different malignant potential true true /api/journal/10019966 REVIEWED true false 10019966 false 10019966 true 2045-2322 Journal FOREIGN 13 1 19820 19820 12 2023 Extracellular vesicles (EV) carry their cargo in a membrane protected form, however, their value in early diagnostics is not well known. Although pancreatic cysts are heterogeneous, they can be clustered into the larger groups of pseudocysts (PC), and serous and mucinous pancreatic cystic neoplasms (S-PCN and M-PCN, respectively). In contrast to PCs and S-PCNs, M-PCNs may progress to malignant pancreatic cancers. Since current diagnostic tools do not meet the criteria of high sensitivity and specificity, novel methods are urgently needed to differentiate M-PCNs from other cysts. We show that cyst fluid is a rich source of EVs that are positive and negative for the EV markers CD63 and CD81, respectively. Whereas we found no difference in the EV number when comparing M-PCN with other pancreatic cysts, our EV-based biomarker identification showed that EVs from M-PCNs had a higher level of miR-200b. We also prove that not only EV-derived, but also total cyst fluid miR-200b discriminates patients with M-PCN from other pancreatic cysts with a higher sensitivity and specificity compared to other diagnostic methods, providing the possibility for clinical applications. Our results show that measuring miR-200b in cyst fluid-derived EVs or from cyst fluid may be clinically important in categorizing patients. Funding 2033443 /api/funding/2033443 false true Funding 2033444 /api/funding/2033444 false true Funding 2033445 /api/funding/2033445 false true Funding 2033446 /api/funding/2033446 false true Funding 2033447 /api/funding/2033447 false true true NATIONAL 2023 true true true false true false GOLD 2026-05-23 true https://doi.org/10.1038/s41598-023-47129-1 4 0 4 4 0 4 4 4 4 4 4 4 4 4 0 0 4 4 4 4 0 7 7 Folyóiratcikk Journal Article 24 4 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 2 2 2 2 2025 0 2 2 2 2 D1 A nemzetközi false 10012601,10015652 false false false 2023-11-19T09:43:58.294+0000 Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); HUN-REN-SE Transzlációs Extracelluláris Vezikul... (SE / AOK / I / GSII); Kísérleti Orvostudományi Kutatóintézet; Patológiai, Igazságügyi és Biztosítási Orvostan... (SE / AOK / I); Sebészeti, Transzplantációs és Gasztroenterológ... 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PersonAuthorship 112185275 /api/authorship/112185275 9 0.1 false true true Author 10023628 /api/author/10023628 Szűcs Ákos true 10023628 true Szücs Ákos true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 112185276 /api/authorship/112185276 10 0.1 false true true Author 10012601 /api/author/10012601 Wiener Zoltán true 10012601 true Wiener Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24955330 /api/publicationidentifier/24955330 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1038/s41598-023-47129-1 https://doi.org/10.1038/s41598-023-47129-1 false true PublicationIdentifier 24992573 /api/publicationidentifier/24992573 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL 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ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/34371433 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10066533"><a href="/gui2/?type=authors&mode=browse&sel=10066533" target="_blank">Benke Márton (<span class="authorship-author-name">Benke Márton</span> <span class="authorAux-mtmt"> Orvosi tudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013473"><a href="/gui2/?type=authors&mode=browse&sel=10013473" target="_blank">Zeöld Anikó<sup>*</sup> (<span class="authorship-author-name">Zeöld Anikó</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009113"><a href="/gui2/?type=authors&mode=browse&sel=10009113" target="_blank">Kittel Ágnes (<span class="authorship-author-name">Kittel Ágnes</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; Kísérleti Orvostudományi Kutatóintézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071730"><a href="/gui2/?type=authors&mode=browse&sel=10071730" target="_blank">Khamari Delaram (<span class="authorship-author-name">Khamari Delaram</span> <span class="authorAux-mtmt"> Extracellular vesicles</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Genetikai, Sejt- és Immunbiológiai Intézet">GSII</span>/HUN-REN-SE Transzlációs Extracelluláris Vezikula Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015652"><a href="/gui2/?type=authors&mode=browse&sel=10015652" target="_blank">Hritz István (<span class="authorship-author-name">Hritz István</span> <span class="authorAux-mtmt"> gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10083896"><a href="/gui2/?type=authors&mode=browse&sel=10083896" target="_blank">Horváth Miklós (<span class="authorship-author-name">Horváth Miklós</span> <span class="authorAux-mtmt"> belgyógyászat, gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10072907"><a href="/gui2/?type=authors&mode=browse&sel=10072907" target="_blank">Keczer Bánk (<span class="authorship-author-name">Keczer Bánk</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023807"><a href="/gui2/?type=authors&mode=browse&sel=10023807" target="_blank">Borka Katalin (<span class="authorship-author-name">Borka Katalin</span> <span class="authorAux-mtmt"> patologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai, Igazságügyi és Biztosítási Orvostani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023628"><a href="/gui2/?type=authors&mode=browse&sel=10023628" target="_blank">Szücs Ákos<sup>**</sup> ✉ (<span class="authorship-author-name">Szűcs Ákos</span> <span class="authorAux-mtmt"> Sebészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Sebészeti, Transzplantációs és Gasztroenterológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012601"><a href="/gui2/?type=authors&mode=browse&sel=10012601" target="_blank">Wiener Zoltán ✉ (<span class="authorship-author-name">Wiener Zoltán</span> <span class="authorAux-mtmt"> Sejtbiológia, tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34371433" target="_blank">MiR-200b categorizes patients into pancreas cystic lesion subgroups with different malignant potential</a></div> <div> <span class="journal-title">SCIENTIFIC REPORTS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2045-2322">2045-2322</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">1</span> <span class="page"> Paper 19820. 12 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1038/s41598-023-47129-1" target="_blank" href="https://doi.org/10.1038/s41598-023-47129-1"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="180529" target="_blank" href="http://real.mtak.hu/180529"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001104793000034" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001104793000034"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85176445295" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85176445295"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37963969" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37963969&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 4</span> | Független: 4 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 4 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;4 | DOI jelölt:&nbsp;4 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34371433&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34371433</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (137554) Támogató: OTKA, Thematic Institutional Excellence Programme(TKP2021-EGA-24) Támogató: Emberi Erőforrások Minisztériuma, (ÚNKP-22-5-SE-10), (132118/AOGEN/2020), (BO/00131/20/8) Támogató: Bolyai János Kutatási Ösztöndíj </div> <div class="lastModified">Utolsó módosítás: 2024.04.17. 17:13 Lévayné Deseő Katalin (MTMT Központi admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.17. 17:13 Lévayné Deseő Katalin (MTMT Központi admin) </div> </div></div>