Background. Cardiovascular disease, which is mainly caused by coronary atheroscle-rosis,
is one of the leading causes of death and disability worldwide. Gut microbiota likely
play an important role in coronary atherosclerosis. This study aims to investigate
the microbiota profile of adults with coronary atherosclerosis to provide a theoretical
basis for future research.Methods. Fecal samples were collected from 35 adult patients
diagnosed with coronary atherosclerosis and 32 healthy adults in Nanjing, China, and
the V3-V4 region of 16S rDNA genes was sequenced using high-throughput sequencing.
Differences in alpha diversity, beta diversity, and gut microbiota composition between
the two groups were then compared.Results. A beta diversity analysis revealed significant
differences between adults with coronary atherosclerosis and controls, but there was
no statistical difference in alpha diversity between the two groups. There were also
differences in the composition of the gut microbiota between the two groups. The genera,
Megamonas, Streptococcus, Veillonella, Ruminococcus_torques_group, Prevotella_2, Tyzzerella_4,
were identified as potential biomarkers for coronary atherosclerosis.Conclusion. There
are some differences in the gut microbiota of adults with coronary atherosclerosis
compared to healthy adults. The insights from this study could be used to explore
microbiome-based mechanisms for coronary atherosclerosis.
