https://m2.mtmt.hu/ hun 2026-04-04 20:50 JournalArticle 34326760 APPROVED true Epigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA, United States Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States Genetics, Bioinformatics and Computational Biology Program, Virginia Tech, Blacksburg, VA, United States School of Animal Sciences, Virginia Tech, Blacksburg, VA, United States School of Neuroscience, Virginia Tech, Blacksburg, VA, United States Export Date: 14 November 2023 Correspondence Address: Xie, H.; Epigenomics and Computational Biology Lab, United States; email: davidxie@vt.edu Chemicals/CAS: nestin, 146315-66-4 Tradenames: ChemiDoc, Biorad; Ethos XT 17, Noldus Ethovision; Novaseq 6000, Illumina; RNAeasy Mini, Qiagen Manufacturers: Biorad; Illumina; Noldus Ethovision; Qiagen Funding details: National Institutes of Health, NIH, ES031521, MH120498, NS094574, NSF1922428, T32OD028239 Funding details: Virginia-Maryland College of Veterinary Medicine Funding details: Edward Via College of Osteopathic Medicine, VCOM Funding text 1: This work was supported by NIH grant T32OD028239, NS094574, MH120498, ES031521, and NSF1922428, the Center for One Health Research at the Virginia-Maryland College of Veterinary Medicine and the Edward Via College of Osteopathic Medicine, and the Fralin Life Sciences Institute faculty development fund for HX. 0 false 2025-08-26T10:07:28.349+0000 2023-11-14T13:56:11.661+0000 2023-11-14T13:51:33.483+0000 true 10065463 Turek Márta /api/admin/10065463 Admin Turek Márta (KOKI admin 4) true 2025-08-26T10:05:53.586+0000 2025-08-26T10:05:53.586+0000 false false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Swilley, C. true true /api/journal/39990 REVIEWED FRONTIERS IN NEUROSCIENCE 1662-4548 1662-453X true false 39990 false 39990 true 1662-4548 1662-453X Journal FOREIGN 17 1240209 1240209 2023 The transcription factor EGR1 is instrumental in numerous neurological processes, encompassing learning and memory as well as the reaction to stress. Egr1 complete knockout mice demonstrate decreased depressive or anxiety-like behavior and impaired performance in spatial learning and memory. Nevertheless, the specific functions of Egr1 in distinct cell types have been largely underexplored. In this study, we cataloged the behavioral and transcriptomic character of Nestin-Cre mediated Egr1 conditional knockout (Egr1cKO) mice together with their controls. Although the conditional knockout did not change nociceptive or anxiety responses, it triggered changes in female exploratory activity during anxiety testing. Hippocampus-dependent spatial learning in the object location task was unaffected, but female Egr1cKO mice did exhibit poorer retention during testing on a contextual fear conditioning task compared to males. RNA-seq data analyses revealed that the presence of the floxed Egr1 cassette or Nestin-Cre driver alone exerts a subtle influence on hippocampal gene expression. The sex-related differences were amplified in Nestin-Cre mediated Egr1 conditional knockout mice and female mice are more sensitive to the loss of Egr1 gene. Differentially expressed genes resulted from the loss of Egr1 in neuronal cell lineage were significantly associated with the regulation of Wnt signaling pathway, extracellular matrix, and axon guidance. Altogether, our results demonstrate that Nestin-Cre and the loss of Egr1 in neuronal cell lineage have distinct impacts on hippocampal gene expression in a sex-specific manner. Copyright © 2023 Swilley, Lin, Zheng, Xu, Liu, Jarome, Hodes and Xie. 2023 true true true false false GOLD 2025-08-26 false http://www.frontiersin.org/neuroscience 0 0 0 0 0 0 0 0 0 0 0 0 1 1 Q2 false false false false 2024-02-12T13:56:11.468+0000 8 60 0 8 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 111839538 /api/authorship/111839538 Swilley, C. 1 0.125 true false false Swilley C. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 111839539 /api/authorship/111839539 Lin, Y. 2 0.125 false false false Lin Y. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 111839540 /api/authorship/111839540 Zheng, Y. 3 0.125 false false false Zheng Y. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 111839541 /api/authorship/111839541 Xu, X. 4 0.125 false false false Xu X. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 111839542 /api/authorship/111839542 Liu, M. 5 0.125 false false false Liu M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 111839543 /api/authorship/111839543 Jarome, T. 6 0.125 false false false Jarome T. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 111839544 /api/authorship/111839544 Hodes, G.E. 7 0.125 false false false Hodes G.E. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 111839545 /api/authorship/111839545 Xie, H. ✉ 8 0.125 false true true Xie H. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24844676 /api/publicationidentifier/24844676 DOI: 10.3389/fnins.2023.1240209 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 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true 1065769 true Keyword 1098402 /api/keyword/1098402 early growth response factor 1 true 1098402 true Keyword 1111820 /api/keyword/1111820 tail flick test true 1111820 true Keyword 1127901 /api/keyword/1127901 Differential gene expression true 1127901 true Keyword 1140581 /api/keyword/1140581 elevated plus maze test true 1140581 true Keyword 1190101 /api/keyword/1190101 synaptogenesis true 1190101 true Keyword 1204972 /api/keyword/1204972 hot plate test true 1204972 true Keyword 1249048 /api/keyword/1249048 RNA-Seq true 1249048 true Keyword 1381243 /api/keyword/1381243 experimental behavioral test true 1381243 true Keyword 1499953 /api/keyword/1499953 Egr1 true true Keyword 1503259 /api/keyword/1503259 Morris water maze test true true Keyword 1517239 /api/keyword/1517239 fear conditioning test true true Keyword 3221989 /api/keyword/3221989 Novel spatial object test true true SjrRating 11402407 /api/sjrrating/11402407 sjr:Q2 (2023) Scopus - Neuroscience (miscellaneous) FRONTIERS IN 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(2023) FRONTIERS IN NEUROSCIENCE 1662-4548 1662-453X 17<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Swilley C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lin Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zheng Y. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Xu X. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Liu M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jarome T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hodes G.E. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Xie H. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34326760" target="_blank">Sex linked behavioral and hippocampal transcriptomic changes in mice with cell-type specific Egr1 loss</a></div> <div> <span class="journal-title">FRONTIERS IN NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-4548">1662-4548</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-453X">1662-453X</a>)</span>: <span class="journal-volume">17</span> <span class="page"> Paper 1240209. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fnins.2023.1240209" target="_blank" href="https://doi.org/10.3389/fnins.2023.1240209"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001095061200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001095061200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175633835" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175633835"> Scopus </a> </span> </span> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34326760&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34326760</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2023.11.14. 14:56 Turek Márta (KOKI admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Epigenomics and Computational Biology Lab, Fralin Life Sciences Institute, Virginia Tech, Blacksburg, VA, United States Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States Genetics, Bioinformatics and Computational Biology Program, Virginia Tech, Blacksb...</pre> </div></div>