Inorganic complexes of iron and sulfur, that is, iron-sulfur [FeS] clusters, have
played a fundamental role in life on Earth since the prebiotic period. These clusters
were involved in elemen-tary reactions leading to the emergence of life and, since
then, gained function in processes, such as respiration, replication, transcription,
and the immune response. We discuss how three [FeS] proteins involved in the innate
immune response play a role in oncogene expression/function and oncometabolism. Our
analysis highlights the importance of future research into understanding the [FeS]
clusters' roles in cancer progression and proliferation. The outcomes of these studies
will help identify new targets and develop new anticancer therapeutics.
