A mitokondriumok szerepének vizsgálata humán faggyúmirigyek (kór)élettanában(FK 134235)
Funder: NRDIO
Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009)
Funder: EFOP-VEKOP
A faggyúmirigyek és az akne (kór)élettanának új aspektusai(BO/00660/21/5) Funder:
MTA Bolyai pályázat
A faggyúmirigyek és az akne (kór)élettanának újabb aspektusai(ÚNKP-22-5-DE-427) Funder:
NRDIO
A faggyúmirigyek és az akne (kór)élettanának vizsgálata(ÚNKP-23-5-DE-477) Funder:
NRDIO
Változatos biológiai hatással rendelkező kannabidiol és kannabigerol származékok szintézise(ÚNKP-22-3-II-DE-85)
Funder: NRDIO
Programme EXCELES(LX22NPO5103) Funder: European Commission (EC)
A Virológiai Nemzeti Laboratórium komplex fejlesztése(RRF-2.3.1-21-2022-00010) Funder:
National Laboratory for Health Security
(−)-Cannabidiol (CBD) and (−)-cannabigerol (CBG) are two major non-psychotropic phytocannabinoids
that have many beneficial biological properties. However, due to their low water solubility
and prominent first-pass metabolism, their oral bioavailability is moderate, which
is unfavorable for medicinal use. Therefore, there is a great need for appropriate
chemical modifications to improve their physicochemical and biological properties.
In this study, Mannich-type reaction was used for the synthetic modification of CBD
and CBG for the first time, and thus fifteen new cannabinoid derivatives containing
one or two tertiary amino groups were prepared. Thereafter the antiviral, antiproliferative
and antibacterial properties of the derivatives and their effects on certain skin
cells were investigated. Some modified CBD derivatives showed remarkable antiviral
activity against SARS-CoV-2 without cytotoxic effect, while synthetic modifications
on CBG resulted in a significant increase in antiproliferative activity in some cases
compared to the parent compound.
