https://m2.mtmt.hu/ eng 2026-04-30 12:58 JournalArticle 34310821 VALIDATED true 0 false 2026-04-23T10:14:54.955+0000 2025-07-11T11:03:36.209+0000 2023-11-12T20:57:28.849+0000 true 521 Szuper Admin /api/admin/521 Admin true 2026-02-08T20:21:23.991+0000 2026-02-08T20:21:23.991+0000 2025-07-11T11:03:36.460+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Heymach, John V. Perioperative Durvalumab for Resectable Non-Small-Cell Lung Cancer true true /api/journal/1394667 REVIEWED true false 1394667 false 1394667 true 0028-4793 1533-4406 Journal FOREIGN 389 18 1672 1684 1672 13 2023 Background Neoadjuvant or adjuvant immunotherapy can improve outcomes in patients with resectable non-small-cell lung cancer (NSCLC). Perioperative regimens may combine benefits of both to improve long-term outcomes.Methods We randomly assigned patients with resectable NSCLC (stage II to IIIB [N2 node stage] according to the eighth edition of the AJCC Cancer Staging Manual) to receive platinum-based chemotherapy plus durvalumab or placebo administered intravenously every 3 weeks for 4 cycles before surgery, followed by adjuvant durvalumab or placebo intravenously every 4 weeks for 12 cycles. Randomization was stratified according to disease stage (II or III) and programmed death ligand 1 (PD-L1) expression (>= 1% or <1%). Primary end points were event-free survival (defined as the time to the earliest occurrence of progressive disease that precluded surgery or prevented completion of surgery, disease recurrence [assessed in a blinded fashion by independent central review], or death from any cause) and pathological complete response (evaluated centrally).Results A total of 802 patients were randomly assigned to receive durvalumab (400 patients) or placebo (402 patients). The duration of event-free survival was significantly longer with durvalumab than with placebo; the stratified hazard ratio for disease progression, recurrence, or death was 0.68 (95% confidence interval [CI], 0.53 to 0.88; P=0.004) at the first interim analysis. At the 12-month landmark analysis, event-free survival was observed in 73.4% of the patients who received durvalumab (95% CI, 67.9 to 78.1), as compared with 64.5% of the patients who received placebo (95% CI, 58.8 to 69.6). The incidence of pathological complete response was significantly greater with durvalumab than with placebo (17.2% vs. 4.3% at the final analysis; difference, 13.0 percentage points; 95% CI, 8.7 to 17.6; P<0.001 at interim analysis of data from 402 patients). Event-free survival and pathological complete response benefit were observed regardless of stage and PD-L1 expression. Adverse events of maximum grade 3 or 4 occurred in 42.4% of patients with durvalumab and in 43.2% with placebo. Data from 62 patients with documented EGFR or ALK alterations were excluded from the efficacy analyses in the modified intention-to-treat population.Conclusions In patients with resectable NSCLC, perioperative durvalumab plus neoadjuvant chemotherapy was associated with significantly greater event-free survival and pathological complete response than neoadjuvant chemotherapy alone, with a safety profile that was consistent with the individual agents. 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false false false 2024-06-18T15:51:13.032+0000 2 9 0 27 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 111707775 /api/authorship/111707775 1 0.035714287 true false true Heymach John V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707776 /api/authorship/111707776 2 0.035714287 false false false Harpole David true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707777 /api/authorship/111707777 3 0.035714287 false false false Mitsudomi Tetsuya true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707778 /api/authorship/111707778 4 0.035714287 false false false Taube Janis M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707779 /api/authorship/111707779 5 0.035714287 false false false Author 10003448 /api/author/10003448 Gálffy Gabriella true 10003448 true Galffy Gabriella true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707780 /api/authorship/111707780 6 0.035714287 false false false Hochmair Maximilian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707781 /api/authorship/111707781 7 0.035714287 false false false Winder Thomas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707782 /api/authorship/111707782 8 0.035714287 false false false Zukov Ruslan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707783 /api/authorship/111707783 9 0.035714287 false false false Garbaos Gabriel true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707784 /api/authorship/111707784 10 0.035714287 false false false Gao Shugeng true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707785 /api/authorship/111707785 11 0.035714287 false false false Kuroda Hiroaki true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707786 /api/authorship/111707786 12 0.036 false false false Author 10029172 /api/author/10029172 Ostoros Gyula true 10029172 true Ostoros Gyula true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707787 /api/authorship/111707787 13 0.035714287 false false false Tran Tho V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707788 /api/authorship/111707788 14 0.035714287 false false false You Jian true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707789 /api/authorship/111707789 15 0.035714287 false false false Lee Kang-Yun true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707790 /api/authorship/111707790 16 0.035714287 false false false Antonuzzo Lorenzo true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707791 /api/authorship/111707791 17 0.035714287 false false false Papai-Szekely Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707792 /api/authorship/111707792 18 0.035714287 false false false Akamatsu Hiroaki true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707793 /api/authorship/111707793 19 0.035714287 false false false Biswas Bivas true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707794 /api/authorship/111707794 20 0.035714287 false false false Spira Alexander true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707795 /api/authorship/111707795 21 0.035714287 false false false Crawford Jeffrey true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707796 /api/authorship/111707796 22 0.035714287 false false false Le Ha T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707797 /api/authorship/111707797 23 0.035714287 false false false Aperghis Mike true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707798 /api/authorship/111707798 24 0.035714287 false false false Doherty Gary J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707799 /api/authorship/111707799 25 0.035714287 false false false Mann Helen true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707800 /api/authorship/111707800 26 0.035714287 false false false Fouad Tamer M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 111707801 /api/authorship/111707801 27 0.035714287 false true false Reck Martin true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true OrgAuthorship 111707802 /api/authorship/111707802 28 0.036 false false false true false false AuthorshipType 30 /api/authorshiptype/30 -29 true -29 true false true PublicationIdentifier 24810962 /api/publicationidentifier/24810962 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1056/NEJMoa2304875 https://doi.org/10.1056/NEJMoa2304875 false true PublicationIdentifier 24810961 /api/publicationidentifier/24810961 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001089765700001 https://www.webofscience.com/wos/woscc/full-record/001089765700001 false true PublicationIdentifier 27551835 /api/publicationidentifier/27551835 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85176734164 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85176734164 false true Classification 12215 /api/classification/12215 true true SjrRating 11397150 /api/sjrrating/11397150 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/34310821 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Heymach John V. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Harpole David </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mitsudomi Tetsuya </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Taube Janis M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003448"><a href="/gui2/?type=authors&mode=browse&sel=10003448" target="_blank">Galffy Gabriella (<span class="authorship-author-name">Gálffy Gabriella</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hochmair Maximilian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Winder Thomas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zukov Ruslan </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Garbaos Gabriel </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gao Shugeng </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kuroda Hiroaki </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029172"><a href="/gui2/?type=authors&mode=browse&sel=10029172" target="_blank">Ostoros Gyula (<span class="authorship-author-name">Ostoros Gyula</span> <span class="authorAux-mtmt"> Pulmonológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tran Tho V. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >You Jian </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Lee Kang-Yun </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Antonuzzo Lorenzo </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Papai-Szekely Zsolt </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Akamatsu Hiroaki </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Biswas Bivas </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Spira Alexander </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Crawford Jeffrey </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Le Ha T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Aperghis Mike </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Doherty Gary J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Mann Helen </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Fouad Tamer M. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Reck Martin </span> </div> <div class="autype autype-29"> Collaborative Organization: <span class="author-affil">AEGEAN Invest</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34310821" target="_blank">Perioperative Durvalumab for Resectable Non-Small-Cell Lung Cancer</a></div> <div> <span class="journal-title">NEW ENGLAND JOURNAL OF MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0028-4793">0028-4793</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1533-4406">1533-4406</a>)</span>: <span class="journal-volume">389</span> <span class="journal-issue">18</span> <span class="page"> pp 1672-1684 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1056/NEJMoa2304875" target="_blank" href="https://doi.org/10.1056/NEJMoa2304875"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001089765700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001089765700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85176734164" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85176734164"> Scopus </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 476</span> | Independent citation: 448 | Self citation: 28 | Unknown citation: 0 | Number of citations in WoS: 462 | Number of citations in Scopus:&nbsp;307 | WoS/Scopus assigned:&nbsp;476 | Number of citations with DOI:&nbsp;471 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34310821&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34310821</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Study Group ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">WoS-XML</span> </div> <div class="lastModified">Last Modified: 2025.07.11. 13:03 Róbert Milánkovics (PTE ÁOK admin 4) </div> </div></div>