(TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium
Ketosis-prone type 2 diabetes was defined by the World Health Organization in 2019.
According to the literature, the diagnosis is based on the presence of ketosis, islet
autoantibody negativity and preserved insulin secretion. Our meta-analysis assessed
the prevalence and clinical characteristics of ketosis-prone type 2 diabetes among
patients hospitalised with diabetic ketoacidosis (DKA) or ketosis.The systematic search
was performed in five main databases as of 15 October 2021 without restrictions. We
calculated the pooled prevalence of ketosis-prone type 2 diabetes (exposed group)
within the diabetic population under examination, patients with ketoacidosis or ketosis,
to identify the clinical characteristics, and we compared it to type 1 diabetes (the
comparator group). The random effects model provided pooled estimates as prevalence,
odds ratio and mean difference (MD) with 95% confidence intervals.Eleven articles
were eligible for meta-analysis, thus incorporating 2010 patients of various ethnic
backgrounds. Among patients presenting with DKA or ketosis at the onset of diabetes,
35% (95% CI: 24%-49%) had ketosis-prone type 2 diabetes. These patients were older
(MD = 11.55 years; 95% CI: 5.5-17.6) and had a significantly higher body mass index
(BMI) (MD = 5.48 kg/m2 ; 95% CI: 3.25-7.72) than those with type 1 diabetes.Ketosis-prone
type 2 diabetes accounts for one third of DKA or ketosis at the onset of diabetes
in adults. These patients are characterised by islet autoantibody negativity and preserved
insulin secretion. They are older and have a higher BMI compared with type 1 diabetes.
C-peptide and diabetes-related autoantibody measurement is essential to identify this
subgroup among patients with ketosis at the onset of diabetes.
