https://m2.mtmt.hu/ hun 2026-04-16 01:40 JournalArticle 34226600 ADMIN_APPROVED true Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary Department of Medicine, UMass Chan Medical School, Worcester, MA 01655, United States Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, 1122, Hungary Department of Thoracic Surgery, National Institute of Oncology, Semmelweis University, Budapest, 1122, Hungary Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria Pulmonary Hospital Torokbalint, Torokbalint, 2045, Hungary Department of Radiology, National Koranyi Institute of Pulmonology, Budapest, 1122, Hungary Department of Translational Medicine, Lund University, Lund, 22184, Sweden Translational Medicine Institute, Semmelweis University, Budapest, 1094, Hungary Export Date: 8 November 2023 Correspondence Address: Dome, B.; Department of Tumor Biology, Hungary; email: balazs.dome@meduniwien.ac.at Correspondence Address: Lohinai, Z.; Pulmonary Hospital TorokbalintHungary; email: zoltan.lohinai@torokbalintkorhaz.hu Chemicals/CAS: nivolumab, 946414-94-4; pembrolizumab, 1374853-91-4; platinum, 7440-06-4 Tradenames: Bond RX, Leica; Novaseq 6000, Illumina Manufacturers: Illumina; Leica 0 false 2026-03-31T11:22:58.160+0000 2026-01-23T10:49:07.880+0000 2023-10-30T14:16:27.050+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true 2026-01-23T10:49:09.132+0000 2026-01-23T10:49:09.132+0000 2024-09-29T23:15:01.017+0000 true 10058227 Áts József /api/admin/10058227 Admin true 10058227 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dora, David Computed Tomography-Based Quantitative Texture Analysis and Gut Microbial Community Signatures Predict Survival in Non-Small Cell Lung Cancer. true true /api/journal/10032813 REVIEWED true false 10032813 false 10032813 true 2072-6694 Journal FOREIGN 15 20 5091 5091 19 2023 This study aims to combine computed tomography (CT)-based texture analysis (QTA) and a microbiome-based biomarker signature to predict the overall survival (OS) of immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients by analyzing their CT scans (n = 129) and fecal microbiome (n = 58). One hundred and five continuous CT parameters were obtained, where principal component analysis (PCA) identified seven major components that explained 80% of the data variation. Shotgun metagenomics (MG) and ITS analysis were performed to reveal the abundance of bacterial and fungal species. The relative abundance of Bacteroides dorei and Parabacteroides distasonis was associated with long OS (>6 mo), whereas the bacteria Clostridium perfringens and Enterococcus faecium and the fungal taxa Cortinarius davemallochii, Helotiales, Chaetosphaeriales, and Tremellomycetes were associated with short OS (≤6 mo). Hymenoscyphus immutabilis and Clavulinopsis fusiformis were more abundant in patients with high (≥50%) PD-L1-expressing tumors, whereas Thelephoraceae and Lachnospiraceae bacterium were enriched in patients with ICI-related toxicities. An artificial intelligence (AI) approach based on extreme gradient boosting evaluated the associations between the outcomes and various clinicopathological parameters. AI identified MG signatures for patients with a favorable ICI response and high PD-L1 expression, with 84% and 79% accuracy, respectively. The combination of QTA parameters and MG had a positive predictive value of 90% for both therapeutic response and OS. According to our hypothesis, the QTA parameters and gut microbiome signatures can predict OS, the response to therapy, the PD-L1 expression, and toxicity in NSCLC patients treated with ICI, and a machine learning approach can combine these variables to create a reliable predictive model, as we suggest in this research. 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Keyword 1204859 /api/keyword/1204859 true 1204859 true Keyword 1453506 /api/keyword/1453506 true 1453506 true Keyword 1673813 /api/keyword/1673813 true true Keyword 3166641 /api/keyword/3166641 true true SjrRating 11403654 /api/sjrrating/11403654 79 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true Q1 DIRECT true true /api/publication/34226600 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10050618"><a href="/gui2/?type=authors&mode=browse&sel=10050618" target="_blank">Dora David (<span class="authorship-author-name">Dóra Dávid</span> <span class="authorAux-mtmt"> Fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Weiss Glen J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071898"><a href="/gui2/?type=authors&mode=browse&sel=10071898" target="_blank">Megyesfalvi Zsolt (<span class="authorship-author-name">Megyesfalvi Zsolt</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Mellkassebészeti Klinika; <span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Tumorbiológiai Osztály</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gállfy Gabriella </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dulka Edit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048474"><a href="/gui2/?type=authors&mode=browse&sel=10048474" target="_blank">Kerpel-Fronius Anna (<span class="authorship-author-name">Kerpel-Fronius Anna</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Radiológia</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035253"><a href="/gui2/?type=authors&mode=browse&sel=10035253" target="_blank">Berta Judit (<span class="authorship-author-name">Berta Judit</span> <span class="authorAux-mtmt"> onkopulmonológia</span>) </a> </span> <span class="author-affil"><span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Tumorbiológiai Osztály</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003072"><a href="/gui2/?type=authors&mode=browse&sel=10003072" target="_blank">Moldvay Judit (<span class="authorship-author-name">Moldvay Judit</span> <span class="authorAux-mtmt"> Tüdõgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Tumorbiológiai Osztály</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000046"><a href="/gui2/?type=authors&mode=browse&sel=10000046" target="_blank">Dome Balazs ✉ (<span class="authorship-author-name">Döme Balázs</span> <span class="authorAux-mtmt"> Tumor indukált angiogenezis</span>) </a> </span> <span class="author-affil">Országos Onkológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Mellkassebészeti Klinika; <span title="Országos Korányi Pulmonológiai Intézet">OKPI</span>/Tumorbiológiai Osztály</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044743"><a href="/gui2/?type=authors&mode=browse&sel=10044743" target="_blank">Lohinai Zoltan ✉ (<span class="authorship-author-name">Lohinai Zoltán</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34226600" target="_blank">Computed Tomography-Based Quantitative Texture Analysis and Gut Microbial Community Signatures Predict Survival in Non-Small Cell Lung Cancer.</a></div> <div> <span class="journal-title">CANCERS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6694">2072-6694</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">20</span> <span class="page"> Paper 5091. 19 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/cancers15205091" target="_blank" href="https://doi.org/10.3390/cancers15205091"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001096613600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001096613600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175093693" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175093693"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37894458" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37894458&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" Nincs "> <a style="color:black" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175093693&doi=10.3390%2Fcancers15205091&partnerID=40&md5=3409ccbae62f4c62ab94b8c812efed0f" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175093693&doi=10.3390%2Fcancers15205091&partnerID=40&md5=3409ccbae62f4c62ab94b8c812efed0f"> Egyéb URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Oncology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 12</span> | Független: 9 | Függő: 3 | Nem jelölt: 0 | WoS jelölt: 9 | Scopus jelölt:&nbsp;12 | WoS/Scopus jelölt:&nbsp;12 | DOI jelölt:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34226600&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34226600</span> | <span class="status-data status-ADMIN_APPROVED"> Admin láttamozott </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Bolyai Scientific Fellowship(142287), (KH130356), (KKP126790), (2020-1.1.6-JOVO), (ÚNKP-20-3), (UNKP-21-3), (2022 Bolyai Fellowship of the Hungarian Academy of Sciences), (Hungarian Respiratory Society (MPA #2020)) </div> <div class="notDuplums"><a target="_blank" href="/api/publication/34226600/notduplums">1 Nem duplumnak jelölés</a> </div> <div class="lastModified">Utolsó módosítás: 2026.01.23. 11:49 Kozma Bernadett (KK_AOK_Mellkassebeszet_Admin5_KB, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary Department of Medicine, UMass Chan Medical School, Worcester, MA 01655, United States Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, 1122, Hungary Department of Thoracic Surgery, National Instit...</pre> </div></div>