https://m2.mtmt.hu/ eng 2026-03-14 14:28 JournalArticle 34226600 ADMIN_APPROVED true Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary Department of Medicine, UMass Chan Medical School, Worcester, MA 01655, United States Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, 1122, Hungary Department of Thoracic Surgery, National Institute of Oncology, Semmelweis University, Budapest, 1122, Hungary Department of Thoracic Surgery, Comprehensive Cancer Center, Medical University of Vienna, Vienna, 1090, Austria Pulmonary Hospital Torokbalint, Torokbalint, 2045, Hungary Department of Radiology, National Koranyi Institute of Pulmonology, Budapest, 1122, Hungary Department of Translational Medicine, Lund University, Lund, 22184, Sweden Translational Medicine Institute, Semmelweis University, Budapest, 1094, Hungary Export Date: 8 November 2023 Correspondence Address: Dome, B.; Department of Tumor Biology, Hungary; email: balazs.dome@meduniwien.ac.at Correspondence Address: Lohinai, Z.; Pulmonary Hospital TorokbalintHungary; email: zoltan.lohinai@torokbalintkorhaz.hu Chemicals/CAS: nivolumab, 946414-94-4; pembrolizumab, 1374853-91-4; platinum, 7440-06-4 Tradenames: Bond RX, Leica; Novaseq 6000, Illumina Manufacturers: Illumina; Leica 0 false 2026-02-20T17:33:42.947+0000 2026-01-23T10:49:07.880+0000 2023-10-30T14:16:27.050+0000 true 10081340 Pirmann Tamás /api/admin/10081340 Admin true 2026-01-23T10:49:09.132+0000 2026-01-23T10:49:09.132+0000 2024-09-29T23:15:01.017+0000 true 10058227 Áts József /api/admin/10058227 Admin true 10058227 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Dora, David Computed Tomography-Based Quantitative Texture Analysis and Gut Microbial Community Signatures Predict Survival in Non-Small Cell Lung Cancer. true true /api/journal/10032813 REVIEWED true false 10032813 false 10032813 true 2072-6694 Journal FOREIGN 15 20 5091 5091 19 2023 This study aims to combine computed tomography (CT)-based texture analysis (QTA) and a microbiome-based biomarker signature to predict the overall survival (OS) of immune checkpoint inhibitor (ICI)-treated non-small cell lung cancer (NSCLC) patients by analyzing their CT scans (n = 129) and fecal microbiome (n = 58). One hundred and five continuous CT parameters were obtained, where principal component analysis (PCA) identified seven major components that explained 80% of the data variation. Shotgun metagenomics (MG) and ITS analysis were performed to reveal the abundance of bacterial and fungal species. The relative abundance of Bacteroides dorei and Parabacteroides distasonis was associated with long OS (>6 mo), whereas the bacteria Clostridium perfringens and Enterococcus faecium and the fungal taxa Cortinarius davemallochii, Helotiales, Chaetosphaeriales, and Tremellomycetes were associated with short OS (≤6 mo). Hymenoscyphus immutabilis and Clavulinopsis fusiformis were more abundant in patients with high (≥50%) PD-L1-expressing tumors, whereas Thelephoraceae and Lachnospiraceae bacterium were enriched in patients with ICI-related toxicities. An artificial intelligence (AI) approach based on extreme gradient boosting evaluated the associations between the outcomes and various clinicopathological parameters. AI identified MG signatures for patients with a favorable ICI response and high PD-L1 expression, with 84% and 79% accuracy, respectively. The combination of QTA parameters and MG had a positive predictive value of 90% for both therapeutic response and OS. According to our hypothesis, the QTA parameters and gut microbiome signatures can predict OS, the response to therapy, the PD-L1 expression, and toxicity in NSCLC patients treated with ICI, and a machine learning approach can combine these variables to create a reliable predictive model, as we suggest in this research. Funding 2032750 /api/funding/2032750 false true Funding 2032751 /api/funding/2032751 false true Funding 2032752 /api/funding/2032752 false true Funding 2032753 /api/funding/2032753 false true Funding 2032754 /api/funding/2032754 false true Funding 2032755 /api/funding/2032755 false true Funding 2032756 /api/funding/2032756 false true Funding 2032757 /api/funding/2032757 false true true 2023 true true true false true false GOLD 2026-02-20 false http://www.mdpi.com/journal/cancers/ 12 0 12 9 4 12 12 9 12 12 12 9 9 9 3 0 12 9 12 9 0 4 4 Folyóiratcikk Journal Article 24 12 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 2 3 2 2025 0 8 6 8 6 2026 0 1 1 1 1 Q1 false false false false 2023-11-07T09:25:26.532+0000 Anatómiai, Szövet- és Fejlődéstani Intézet (SE / AOK / I); Mellkassebészeti Klinika (SE / AOK / K); Országos Onkológiai Intézet; Radiológia (OKPI); Transzlációs Medicina Intézet (SE / AOK / I); Tumorbiológiai Osztály (OKPI) 7 32 6 10 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 110962040 /api/authorship/110962040 1 0.1 true false false Author 10050618 /api/author/10050618 Dóra Dávid true 10050618 true Dora David true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110962041 /api/authorship/110962041 2 0.1 false false false Weiss Glen J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110962042 /api/authorship/110962042 3 0.1 false false false Author 10071898 /api/author/10071898 Megyesfalvi Zsolt true true Megyesfalvi Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110962043 /api/authorship/110962043 4 0.1 false false false Gállfy Gabriella true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110962044 /api/authorship/110962044 5 0.1 false false false Dulka Edit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110962045 /api/authorship/110962045 6 0.1 false false false Author 10048474 /api/author/10048474 Kerpel-Fronius Anna true 10048474 true Kerpel-Fronius Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110962046 /api/authorship/110962046 7 0.1 false false false Author 10035253 /api/author/10035253 Berta Judit true 10035253 true Berta Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110962047 /api/authorship/110962047 8 0.1 false false false Author 10003072 /api/author/10003072 Moldvay Judit true 10003072 true Moldvay Judit true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110962048 /api/authorship/110962048 9 0.1 false false true Author 10000046 /api/author/10000046 Döme Balázs true 10000046 true Dome Balazs true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110962049 /api/authorship/110962049 10 0.1 false true true Author 10044743 /api/author/10044743 Lohinai Zoltán true 10044743 true Lohinai Zoltan true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24595605 /api/publicationidentifier/24595605 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/cancers15205091 https://doi.org/10.3390/cancers15205091 false true PublicationIdentifier 25004497 /api/publicationidentifier/25004497 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001096613600001 https://www.webofscience.com/wos/woscc/full-record/001096613600001 true true PublicationIdentifier 24711053 /api/publicationidentifier/24711053 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85175093693 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175093693 true true PublicationIdentifier 24595604 /api/publicationidentifier/24595604 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37894458 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37894458&dopt=Abstract false true PublicationIdentifier 31259811 /api/publicationidentifier/31259811 PlainSource 40 /api/publicationsource/40 PublicationSourceType 10006 /api/publicationsourcetype/10006 true true true Egyéb URL Other URL @@@ true true 40 true NONE https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175093693&doi=10.3390%2Fcancers15205091&partnerID=40&md5=3409ccbae62f4c62ab94b8c812efed0f https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175093693&doi=10.3390%2Fcancers15205091&partnerID=40&md5=3409ccbae62f4c62ab94b8c812efed0f false true Keyword 3693 /api/keyword/3693 DUPLUM true 3693 true Keyword 1204859 /api/keyword/1204859 true 1204859 true Keyword 1453506 /api/keyword/1453506 true 1453506 true Keyword 1673813 /api/keyword/1673813 true true Keyword 3166641 /api/keyword/3166641 true true SjrRating 11403654 /api/sjrrating/11403654 79 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2730 /api/classificationexternal/2730 true 2730 true Q1 DIRECT true true /api/publication/34226600 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10050618"><a href="/gui2/?type=authors&mode=browse&sel=10050618" target="_blank">Dora David (<span class="authorship-author-name">Dóra Dávid</span> <span class="authorAux-mtmt"> Fejlődésbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Anatómiai, Szövet- és Fejlődéstani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Weiss Glen J </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071898"><a href="/gui2/?type=authors&mode=browse&sel=10071898" target="_blank">Megyesfalvi Zsolt (<span class="authorship-author-name">Megyesfalvi Zsolt</span> <span class="authorAux-mtmt"> Orvostudomány</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery; <span title="Koranyi National Institute for Pulmonology">OKPI</span>/Department of Tumor Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gállfy Gabriella </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Dulka Edit </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10048474"><a href="/gui2/?type=authors&mode=browse&sel=10048474" target="_blank">Kerpel-Fronius Anna (<span class="authorship-author-name">Kerpel-Fronius Anna</span> <span class="authorAux-mtmt"> radiológia</span>) </a> </span> <span class="author-affil"><span title="Koranyi National Institute for Pulmonology">OKPI</span>/Radiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035253"><a href="/gui2/?type=authors&mode=browse&sel=10035253" target="_blank">Berta Judit (<span class="authorship-author-name">Berta Judit</span> <span class="authorAux-mtmt"> onkopulmonológia</span>) </a> </span> <span class="author-affil"><span title="Koranyi National Institute for Pulmonology">OKPI</span>/Department of Tumor Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10003072"><a href="/gui2/?type=authors&mode=browse&sel=10003072" target="_blank">Moldvay Judit (<span class="authorship-author-name">Moldvay Judit</span> <span class="authorAux-mtmt"> Tüdõgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Koranyi National Institute for Pulmonology">OKPI</span>/Department of Tumor Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000046"><a href="/gui2/?type=authors&mode=browse&sel=10000046" target="_blank">Dome Balazs ✉ (<span class="authorship-author-name">Döme Balázs</span> <span class="authorAux-mtmt"> Tumor indukált angiogenezis</span>) </a> </span> <span class="author-affil">National Institute of Oncology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Thoracic Surgery; <span title="Koranyi National Institute for Pulmonology">OKPI</span>/Department of Tumor Biology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10044743"><a href="/gui2/?type=authors&mode=browse&sel=10044743" target="_blank">Lohinai Zoltan ✉ (<span class="authorship-author-name">Lohinai Zoltán</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34226600" target="_blank">Computed Tomography-Based Quantitative Texture Analysis and Gut Microbial Community Signatures Predict Survival in Non-Small Cell Lung Cancer.</a></div> <div> <span class="journal-title">CANCERS</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2072-6694">2072-6694</a>)</span>: <span class="journal-volume">15</span> <span class="journal-issue">20</span> <span class="page"> Paper 5091. 19 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/cancers15205091" target="_blank" href="https://doi.org/10.3390/cancers15205091"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001096613600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001096613600001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175093693" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175093693"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37894458" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37894458&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:black" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175093693&doi=10.3390%2Fcancers15205091&partnerID=40&md5=3409ccbae62f4c62ab94b8c812efed0f" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85175093693&doi=10.3390%2Fcancers15205091&partnerID=40&md5=3409ccbae62f4c62ab94b8c812efed0f"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cancer Research&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 12</span> | Independent citation: 9 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 9 | Number of citations in Scopus:&nbsp;12 | WoS/Scopus assigned:&nbsp;12 | Number of citations with DOI:&nbsp;12 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34226600&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34226600</span> | <span class="status-data status-ADMIN_APPROVED"> Admin approved </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Bolyai Scientific Fellowship(142287), (KH130356), (KKP126790), (2020-1.1.6-JOVO), (ÚNKP-20-3), (UNKP-21-3), (2022 Bolyai Fellowship of the Hungarian Academy of Sciences), (Hungarian Respiratory Society (MPA #2020)) </div> <div class="notDuplums"><a target="_blank" href="/api/publication/34226600/notduplums">1 marked as not duplum</a> </div> <div class="lastModified">Last Modified: 2026.01.23. 11:49 Bernadett Kozma (KK_AOK_Mellkassebeszet_Admin5_KB, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary Department of Medicine, UMass Chan Medical School, Worcester, MA 01655, United States Department of Tumor Biology, National Koranyi Institute of Pulmonology, Budapest, 1122, Hungary Department of Thoracic Surgery, National Instit...</pre> </div></div>