Background: Hypovitaminosis D is associated with oncogenesis, and the initial level
of Vitamin D may play a role in determining long-term prognosis, relapse-free survival
(RFS) and overall survival (OS). The purpose of our study was to follow up pediatric
cancer patients for a long time in terms of their baseline Vitamin D level and disease
outcomes. Methods: We collected data on the initial 25(OH)D concentration in 117 children
and examined their RFS and OS using Kaplan–Meier curves. Results: The initial 25(OH)D
mean value in the relapsed group was 20.35 ng/mL (SE: 2.05) and in children without
relapse it was 26.14 ng/mL (SE: 1.13). Both the relapse-free and overall Kaplan–Meier
curves showed a tendency for children with lower serum Vitamin D concentrations to
experience cancer recurrence or fatal outcomes sooner than patients with normal serum
levels. Conclusions: Our results indicated a possible correlation between higher pretreatment
serum Vitamin D concentrations and improved overall and relapse-free survival.
