https://m2.mtmt.hu/ hun 2026-09-22 00:51 JournalArticle 34214262 VALIDATED true MTA Bolyai Ösztöndíj BO/00304/20 0 false 2026-09-21T13:25:43.271+0000 2023-11-30T10:59:49.446+0000 2023-10-24T18:48:20.738+0000 true 10014641 Kökény Gábor /api/author/10014641 Author Kökény Gábor (Nefrológia) true 10014641 2025-06-04T07:05:40.377+0000 2023-11-20T11:01:50.873+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Manzéger, Anna true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 21 15520 15520 18 2023 Excessive renal TGF-β production and pro-fibrotic miRNAs are important drivers of kidney fibrosis that lack any efficient treatment. Dysfunctional autophagy might play an important role in the pathogenesis. We aimed to study the yet unknown effects of peroxisome proliferator-activated receptor-γ (PPARγ) agonist pioglitazone (Pio) on renal autophagy and miRNA dysregulation during fibrosis. Mouse primary tubular epithelial cells (PTEC) were isolated, pre-treated with 5 µM pioglitazone, and then stimulated with 10 ng/mL TGF-β1 for 24 h. Male 10-week-old C57Bl6 control (CTL) and TGF-β overexpressing mice were fed with regular chow (TGF) or Pio-containing chow (20 mg/kg/day) for 5 weeks (TGF + Pio). PTEC and kidneys were evaluated for mRNA and protein expression. In PTEC, pioglitazone attenuated (p < 0.05) the TGF-β-induced up-regulation of Col1a1 (1.4-fold), Tgfb1 (2.2-fold), Ctgf (1.5-fold), Egr2 (2.5-fold) mRNAs, miR-130a (1.6-fold), and miR-199a (1.5-fold), inhibited epithelial-to-mesenchymal transition, and rescued autophagy function. In TGF mice, pioglitazone greatly improved kidney fibrosis and related dysfunctional autophagy (increased LC3-II/I ratio and reduced SQSTM1 protein content (p < 0.05)). These were accompanied by 5-fold, 3-fold, 12-fold, and 2-fold suppression (p < 0.05) of renal Ccl2, Il6, C3, and Lgals3 mRNA expression, respectively. Our results implicate that pioglitazone counteracts multiple pro-fibrotic processes in the kidney, including autophagy dysfunction and miRNA dysregulation. Funding 2033484 /api/funding/2033484 (SE250+ Excellence Scholarship for PhD Students) false true Funding 2033485 /api/funding/2033485 (BO/00304/20/5) false true Funding 2033486 /api/funding/2033486 (ÚNKP-22-5-SE-202206201434) false true Funding 2033487 /api/funding/2033487 Hungarian Society of Hypertension false true Funding 2033488 /api/funding/2033488 (Hungarian Society of Nephrology) false true Funding 2033489 /api/funding/2033489 Stipendium Hungaricum Scholarship(Stipendium) Támogató: Tempus false true true 2023 true true true false true false GOLD 2026-09-21 false http://www.mdpi.com/journal/ijms 11 0 11 9 2 11 11 10 4 11 11 9 9 9 2 0 11 9 11 9 0 5 5 Folyóiratcikk Journal Article 24 11 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 2 3 2 2025 0 6 5 6 5 2026 0 2 2 2 2 D1 false 10014641 false false false 2023-11-19T11:01:50.589+0000 Transzlációs Medicina Intézet (SE / AOK / I) 4 19 1 5 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 110863291 /api/authorship/110863291 Manzéger, Anna [Manzéger, Anna (molekuláris genetika), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 1 0.2 true false false Author 10055151 /api/author/10055151 Manzéger Anna (molekuláris genetika) Manzéger Anna true 10055151 true Manzéger Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110863292 /api/authorship/110863292 Garmaa, Gantsetseg [Gantsetseg, Garmaa (miRNA in kidney d...), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 2 0.2 false false false Author 10077906 /api/author/10077906 Gantsetseg Garmaa (miRNA in kidney disease, proximal tubular cell differentiation, Vitamin D, Tuberculosis, maternal health) Gantsetseg Garmaa true true Garmaa Gantsetseg true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110863293 /api/authorship/110863293 Mózes, Miklós M. [Mózes, Miklós (Nephrologia), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 3 0.2 false false false Author 10015693 /api/author/10015693 Mózes Miklós (Nephrologia) Mózes Miklós true 10015693 true Mózes Miklós M. true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110863294 /api/authorship/110863294 Hansmann, Georg 4 0.2 false false false Hansmann Georg true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110863295 /api/authorship/110863295 Kökény, Gábor ✉ [Kökény, Gábor (Nefrológia), szerző] Transzlációs Medicina Intézet (SE / AOK / I) 5 0.2 false true true Author 10014641 /api/author/10014641 Kökény Gábor (Nefrológia) Kökény Gábor true 10014641 true Kökény Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24562309 /api/publicationidentifier/24562309 DOI: 10.3390/ijms242115520 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3390/ijms242115520 https://doi.org/10.3390/ijms242115520 false true PublicationIdentifier 25042010 /api/publicationidentifier/25042010 WoS: 001103287300001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001103287300001 https://www.webofscience.com/wos/woscc/full-record/001103287300001 true true PublicationIdentifier 24967959 /api/publicationidentifier/24967959 Scopus: 85176431928 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85176431928 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85176431928 true true PublicationIdentifier 24967998 /api/publicationidentifier/24967998 PubMed: 37958504 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37958504 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37958504&dopt=Abstract true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 46389364 /api/reference/46389364 1. 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 21<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10055151"><a href="/gui2/?type=authors&mode=browse&sel=10055151" target="_blank">Manzéger Anna (<span class="authorship-author-name">Manzéger Anna</span> <span class="authorAux-mtmt"> molekuláris genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077906"><a href="/gui2/?type=authors&mode=browse&sel=10077906" target="_blank">Garmaa Gantsetseg (<span class="authorship-author-name">Gantsetseg Garmaa</span> <span class="authorAux-mtmt"> miRNA in kidney disease, proximal tubular cell ...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015693"><a href="/gui2/?type=authors&mode=browse&sel=10015693" target="_blank">Mózes Miklós M. (<span class="authorship-author-name">Mózes Miklós</span> <span class="authorAux-mtmt"> Nephrologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hansmann Georg </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014641"><a href="/gui2/?type=authors&mode=browse&sel=10014641" target="_blank">Kökény Gábor ✉ (<span class="authorship-author-name">Kökény Gábor</span> <span class="authorAux-mtmt"> Nefrológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34214262" target="_blank">Pioglitazone Protects Tubular Epithelial Cells during Kidney Fibrosis by Attenuating miRNA Dysregulation and Autophagy Dysfunction Induced by TGF-β</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">21</span> <span class="page"> Paper 15520. 18 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/ijms242115520" target="_blank" href="https://doi.org/10.3390/ijms242115520"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001103287300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001103287300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85176431928" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85176431928"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37958504" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37958504&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 11</span> | Független: 9 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;4 | WoS/Scopus jelölt:&nbsp;11 | DOI jelölt:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34214262&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34214262</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (SE250+ Excellence Scholarship for PhD Students), (BO/00304/20/5), (ÚNKP-22-5-SE-202206201434), Hungarian Society of Hypertension, (Hungarian Society of Nephrology), Stipendium Hungaricum Scholarship(Stipendium) Támogató: Tempus </div> <div class="lastModified">Utolsó módosítás: 2023.11.30. 11:59 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: MTA Bolyai Ösztöndíj BO/00304/20</pre> </div></div>