https://m2.mtmt.hu/ eng 2026-09-20 23:13 JournalArticle 34213292 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Office of Hungary [NKFI FK 138842, K 131627, FK 134751, K 125174, K 139230, VEKOP-2.3.3-15-2017-00016, EFOP-3.6.3-VEKOP-16-2017-00009]; European Union [TKP2021-EGA-25, 739593, LP-2021-14]; Hungarian Academy of Sciences [RRF-2.3.1-21-2022-00003]; Semmelweis University Funding text: The work was supported by the National Research, Development and Innovation Office of Hungary (NKFI FK 138842, K 131627, FK 134751, K 125174, K 139230, VEKOP-2.3.3-15-2017-00016, and EFOP-3.6.3-VEKOP-16-2017-00009), by TKP2021-EGA-25, by the European Union's Horizon 2020 Research and Innovation Program under grant agreement number 739593, by a Momentum Research Grant from the Hungarian Academy of Sciences (LP-2021-14 to ZVV), and by the Harriet Van Vleet Endowment (to GT). Project number RRF-2.3.1-21-2022-00003 has been implemented with the support provided by the European Union. The authors are grateful for the technical assistance of Zsuzsanna Demeter, Katarina Ilankovic (Department of Pharmacology and Pharmacotherapy, Semmelweis University) and Eva Matraine Balogh (Department of Pathology and Experimental Cancer Research, Semmelweis University). Figures 9 and 11 contain artworks produced by Servier Medical Art (https://smart.servier.com/). Open access funding provided by Semmelweis University. 0 false 2026-08-05T17:38:33.181+0000 2026-03-09T16:24:41.368+0000 2023-10-24T11:38:43.505+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2026-07-20T11:17:22.470+0000 2025-01-30T08:25:57.738+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2025-06-04T23:11:56.775+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Hutka, Barbara A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy true true /api/journal/10551 REVIEWED true false 10551 false 10551 true 1671-4083 1745-7254 Journal FOREIGN 45 2 339 353 339 15 2024 Lysophosphatidic acid (LPA) is a bioactive phospholipid mediator that has been found to ameliorate nonsteroidal anti-inflammatory drug (NSAID)-induced gastric injury by acting on lysophosphatidic acid type 2 receptor (LPAR2). In this study, we investigated whether LPAR2 signaling was implicated in the development of NSAID-induced small intestinal injury (enteropathy), another major complication of NSAID use. Wild-type (WT) and Lpar2 deficient ( Lpar2 −/− ) mice were treated with a single, large dose (20 or 30 mg/kg, i.g.) of indomethacin (IND). The mice were euthanized at 6 or 24 h after IND treatment. We showed that IND-induced mucosal enteropathy and neutrophil recruitment occurred much earlier (at 6 h after IND treatment) in Lpar2 −/− mice compared to WT mice, but the tissue levels of inflammatory mediators (IL-1β, TNF-α, inducible COX-2, CAMP) remained at much lower levels. Administration of a selective LPAR2 agonist DBIBB (1, 10 mg/kg, i.g., twice at 24 h and 30 min before IND treatment) dose-dependently reduced mucosal injury and neutrophil activation in enteropathy, but it also enhanced IND-induced elevation of several proinflammatory chemokines and cytokines. By assessing caspase-3 activation, we found significantly increased intestinal apoptosis in IND-treated Lpar2 −/− mice, but it was attenuated after DBIBB administration, especially in non-obese diabetic/severe combined immunodeficiency (NOD/SCID) mice. Finally, we showed that IND treatment reduced the plasma activity and expression of autotaxin (ATX), the main LPA-producing enzyme, and also reduced the intestinal expression of Lpar2 mRNA, which preceded the development of mucosal damage. We conclude that LPAR2 has a dual role in NSAID enteropathy, as it contributes to the maintenance of mucosal integrity after NSAID exposure, but also orchestrates the inflammatory responses associated with ulceration. Our study suggests that IND-induced inhibition of the ATX-LPAR2 axis is an early event in the pathogenesis of enteropathy. Funding 2032575 /api/funding/2032575 false true Funding 2032576 /api/funding/2032576 false true Funding 2032577 /api/funding/2032577 false true Funding 2032578 /api/funding/2032578 false true Funding 2032579 /api/funding/2032579 false true Funding 2032580 /api/funding/2032580 false true Funding 2032581 /api/funding/2032581 false true Funding 2032582 /api/funding/2032582 false true Funding 2032583 /api/funding/2032583 false true Funding 2032584 /api/funding/2032584 false true Funding 2032585 /api/funding/2032585 false true true true 2023 true true true false true false NONE 2026-08-05 false 8 0 7 4 4 7 8 6 7 7 7 4 4 5 3 0 8 5 7 4 0 15 15 Folyóiratcikk Journal Article 24 7 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 1 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 2 3 2 2025 0 2 2 2 2 2026 0 3 1 3 1 D1 false 10017488,10104492 false false false 2023-11-07T14:22:07.074+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); HCEMM-SE Kardiometabolikus Immunológia Kutatócs... (SE / AOK / I / FFI); HUN-REN-SE Cerebrovaszkuláris és Neurokognitív ... (SE / AOK / I / KKI); MTA-SE Momentum Kardio-Onkológia és Kardioimmun... (SE / AOK / I / FFI); MTA-SE Rendszerfarmakológiai Kutatócsoport (SE / AOK / I / FFI); Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Richter Gedeon Nyrt.; Transzlációs Medicina Intézet (SE / AOK / I) 14 52 9 15 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 110855863 /api/authorship/110855863 1 0.067 true false false Author 10069237 /api/author/10069237 Hutka Barbara true true Hutka Barbara true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855864 /api/authorship/110855864 2 0.06666667 false false false Várallyay Anett true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855865 /api/authorship/110855865 3 0.067 false false false Author 10064619 /api/author/10064619 László Szilvia Bianka true 10064619 true László Szilvia B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855866 /api/authorship/110855866 4 0.067 false false false Author 10076872 /api/author/10076872 Tóth András Sebestyén true true Tóth András S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855867 /api/authorship/110855867 5 0.067 false false false Author 10039975 /api/author/10039975 Scheich Bálint true 10039975 true Scheich Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855868 /api/authorship/110855868 6 0.067 false false false Author 10000740 /api/author/10000740 Paku Sándor true 10000740 true Paku Sándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855869 /api/authorship/110855869 7 0.067 false false false Author 10065328 /api/author/10065328 Vörös Imre true 10065328 true Vörös Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855870 /api/authorship/110855870 8 0.067 false false false Author 10012484 /api/author/10012484 Pós Zoltán true 10012484 true Pós Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855871 /api/authorship/110855871 9 0.067 false false false Author 10028393 /api/author/10028393 Varga Zoltán true 10028393 true Varga Zoltán V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855872 /api/authorship/110855872 10 0.06666667 false false false Author 10104492 /api/author/10104492 Norman Derek true true Norman Derek D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855873 /api/authorship/110855873 11 0.067 false false false Author 10057888 /api/author/10057888 Balogh Andrea true 10057888 true Balogh Andrea true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855874 /api/authorship/110855874 12 0.067 false false false Author 10009921 /api/author/10009921 Benyó Zoltán true 10009921 true Benyó Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855875 /api/authorship/110855875 13 0.067 false false false Author 10046134 /api/author/10046134 Tigyi Gabor true 10046134 true Tigyi Gábor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855876 /api/authorship/110855876 14 0.067 false false false Author 10007320 /api/author/10007320 Gyires Klára true 10007320 true Gyires Klára true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855877 /api/authorship/110855877 15 0.067 false true true Author 10017488 /api/author/10017488 Zádori Zoltán Sándor true 10017488 true Zádori Zoltán S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24559846 /api/publicationidentifier/24559846 PlainSource 6 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10.1111/bph.16200 false true Reference 46357911 /api/reference/46357911 86 10.1016/j.ajpath.2017.10.006 false true Reference 46357912 /api/reference/46357912 87 10.1016/j.jcmgh.2022.03.012 false true Reference 46357913 /api/reference/46357913 88 10.1124/jpet.105.098848 false true Reference 46357914 /api/reference/46357914 89 10.1158/2326-6066.CIR-13-0043-T false true Reference 46357915 /api/reference/46357915 90 10.3390/cells11142243 false true /api/publication/34213292 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10069237"><a href="/gui2/?type=authors&mode=browse&sel=10069237" target="_blank">Hutka Barbara (<span class="authorship-author-name">Hutka Barbara</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; Gedeon Richter Plc</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Várallyay Anett </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064619"><a href="/gui2/?type=authors&mode=browse&sel=10064619" target="_blank">László Szilvia B. (<span class="authorship-author-name">László Szilvia Bianka</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076872"><a href="/gui2/?type=authors&mode=browse&sel=10076872" target="_blank">Tóth András S. (<span class="authorship-author-name">Tóth András Sebestyén</span> <span class="authorAux-mtmt"> orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039975"><a href="/gui2/?type=authors&mode=browse&sel=10039975" target="_blank">Scheich Bálint (<span class="authorship-author-name">Scheich Bálint</span> <span class="authorAux-mtmt"> Patológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000740"><a href="/gui2/?type=authors&mode=browse&sel=10000740" target="_blank">Paku Sándor (<span class="authorship-author-name">Paku Sándor</span> <span class="authorAux-mtmt"> Onkológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065328"><a href="/gui2/?type=authors&mode=browse&sel=10065328" target="_blank">Vörös Imre (<span class="authorship-author-name">Vörös Imre</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE System Pharmacology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012484"><a href="/gui2/?type=authors&mode=browse&sel=10012484" target="_blank">Pós Zoltán (<span class="authorship-author-name">Pós Zoltán</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Genetics, Cell- and Immunology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028393"><a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltán V. (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> kardiovaszkuláris kutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/HCEMM-SU Cardiometabolic Immunology Research Group; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Pharmacology and Pharmacotherapy">DPP</span>/MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10104492"><a href="/gui2/?type=authors&mode=browse&sel=10104492" target="_blank">Norman Derek D. (<span class="authorship-author-name">Norman Derek</span> <span class="authorAux-mtmt"> Cellular and molecular biology</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057888"><a href="/gui2/?type=authors&mode=browse&sel=10057888" target="_blank">Balogh Andrea (<span class="authorship-author-name">Balogh Andrea</span> <span class="authorAux-mtmt"> Tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyó Zoltán (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/HUN-REN-SE Cerebrovascular and Neurocognitive Diseases Research Group</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10046134"><a href="/gui2/?type=authors&mode=browse&sel=10046134" target="_blank">Tigyi Gábor (<span class="authorship-author-name">Tigyi Gabor</span> <span class="authorAux-mtmt"> Lipid biokemia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10007320"><a href="/gui2/?type=authors&mode=browse&sel=10007320" target="_blank">Gyires Klára (<span class="authorship-author-name">Gyires Klára</span> <span class="authorAux-mtmt"> Farmakológia, gasztrointesztinális farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10017488"><a href="/gui2/?type=authors&mode=browse&sel=10017488" target="_blank">Zádori Zoltán S. ✉ (<span class="authorship-author-name">Zádori Zoltán Sándor</span> <span class="authorAux-mtmt"> Farmakológia, gasztrointesztinális farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Pharmacology and Pharmacotherapy</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34213292" target="_blank">A dual role of lysophosphatidic acid type 2 receptor (LPAR2) in nonsteroidal anti-inflammatory drug-induced mouse enteropathy</a></div> <div> <span class="journal-title">ACTA PHARMACOLOGICA SINICA</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1671-4083">1671-4083</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1745-7254">1745-7254</a>)</span>: <span class="journal-volume">45</span> <span class="journal-issue">2</span> <span class="page"> pp 339-353 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s41401-023-01175-7" target="_blank" href="https://doi.org/10.1038/s41401-023-01175-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001081142800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001081142800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="7645529" target="_blank" href="https://www.webofscience.com/wos/cscd/full-record/7645529"> Wos-CSCD (Chinese) </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85173679488" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85173679488"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37816857" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37816857&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology (medical)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Pharmacology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 8</span> | Independent citation: 5 | Self citation: 3 | Unknown citation: 0 | Number of citations in WoS: 6 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;7 | Number of citations with DOI:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34213292&sort=publishedYear,desc&sort=title"> Number of cited publications: 15 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34213292</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (FK 138842), (131627) Funder: HSRF, (FK 134751) Funder: HSRF, (K-125174) Funder: NR-DIO, (K-139230) Funder: NRDIO, (VEKOP-2.3.3.-15-2017-00016), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP, (TKP2021-EGA-25), (LP-2021-14), (RRF-2.3.1-21-2022-00003), HCEMM(739593) Funder: Horizon 2020 </div> <div class="lastModified">Last Modified: 2026.03.09. 17:24 Derek Norman (Cellular and molecular biology) </div> <div class="lockedBy">Centrally managed 2025.06.05. 01:11 Katalin Lévayné Deseő (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Research, Development and Innovation Office of Hungary [NKFI FK 138842, K 131627, FK 134751, K 125174, K 139230, VEKOP-2.3.3-15-2017-00016, EFOP-3.6.3-VEKOP-16-2017-00009]; European Union [TKP2021-EGA-25, 739593, LP-2021-14]; Hungarian Academy of Sciences [RRF-2.3.1-21-2022-00003]; Semmelweis University Funding text: The work was supported b...</pre> </div></div>