https://m2.mtmt.hu/ hun 2026-09-22 11:58 JournalArticle 34213267 VALIDATED true 0 false 2026-06-30T09:23:57.227+0000 2024-02-01T09:27:03.867+0000 2023-10-24T11:30:57.791+0000 true 10069606 Pintér Ibolya Katalin /api/admin/10069606 Admin true 2024-11-25T09:05:20.553+0000 2024-11-25T09:05:20.553+0000 2024-02-01T09:27:04.170+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 Admin 10067876 /api/admin/10067876 Ladányi Gusztáv true true Admin 10097589 /api/admin/10097589 Szendrei László true true 2024-10-17T16:46:37.543+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Janovicz, Anna Autotaxin–lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling true true /api/journal/34079 REVIEWED true false 34079 false 34079 true 1535-3702 1535-3699 Journal FOREIGN 248 20 1887 1894 1887 8 2023 Lysophosphatidylcholine (LPC) is a bioactive lipid that has been shown to attenuate endothelium-dependent vasorelaxation contributing to endothelial dysfunction; however, the underlying mechanisms are not well understood. In this study, we investigated the molecular mechanisms involved in the development of LPC-evoked impairment of endothelium-dependent vasorelaxation. In aortic rings isolated from wild-type (WT) mice, a 20-min exposure to LPC significantly reduced the acetylcholine chloride (ACh)–induced vasorelaxation indicating the impairment of normal endothelial function. Interestingly, pharmacological inhibition of autotaxin (ATX) by GLPG1690 partially reversed the endothelial dysfunction, suggesting that lysophosphatidic acid (LPA) derived from LPC may be involved in the effect. Therefore, the effect of LPC was also tested in aortic rings isolated from different LPA receptor knock-out (KO) mice. LPC evoked a marked reduction in ACh-dependent vasorelaxation in Lpar1, Lpar2, and Lpar4 KO, but its effect was significantly attenuated in Lpar5 KO vessels. Furthermore, addition of superoxide dismutase reduced the LPC-induced endothelial dysfunction in WT but not in the Lpar5 KO mice. In addition, LPC increased H 2 O 2 release from WT vessels, which was significantly reduced in Lpar5 KO vessels. Our findings indicate that the ATX–LPA–LPA 5 receptor axis is involved in the development of LPC-induced impairment of endothelium-dependent vasorelaxation via LPA 5 receptor–mediated reactive oxygen species production. Taken together, in this study, we identified a new pathway contributing to the development of LPC-induced endothelial dysfunction. 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(SE / AOK / I / TMI); Transzlációs Medicina Intézet (SE / AOK / I); Élettani Intézet (SE / AOK / I) 7 26 3 9 0 true 10067876 10097589 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 110855678 /api/authorship/110855678 1 0.111 true false false Author 10067206 /api/author/10067206 Janovicz Anna true true Janovicz Anna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855679 /api/authorship/110855679 2 0.111 false false false Author 10073985 /api/author/10073985 Majer Aliz true true Majer Aliz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855680 /api/authorship/110855680 3 0.111 false false false Author 10020915 /api/author/10020915 Kosztelnik Mónika true 10020915 true Kosztelnik Mónika true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855681 /api/authorship/110855681 4 0.111 false false false Author 10013679 /api/author/10013679 Geiszt Miklós true 10013679 true Geiszt Miklós true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855682 /api/authorship/110855682 5 0.11111111 false false false Chun Jerold true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855683 /api/authorship/110855683 6 0.11111111 false false false Ishii Satoshi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855684 /api/authorship/110855684 7 0.111 false false false Author 10046134 /api/author/10046134 Tigyi Gabor true 10046134 true Tigyi Gábor József true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855685 /api/authorship/110855685 8 0.111 false false false Author 10009921 /api/author/10009921 Benyó Zoltán true 10009921 true Benyó Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 110855686 /api/authorship/110855686 9 0.111 false true true Author 10025626 /api/author/10025626 Ruisanchez Éva true 10025626 true Ruisanchez Éva true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24559780 /api/publicationidentifier/24559780 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1177/15353702231199081 https://doi.org/10.1177/15353702231199081 false true PublicationIdentifier 24673053 /api/publicationidentifier/24673053 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001086876200001 https://www.webofscience.com/wos/woscc/full-record/001086876200001 false true PublicationIdentifier 24566054 /api/publicationidentifier/24566054 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46356895 /api/reference/46356895 38 10.1016/j.pharmthera.2009.02.002 false true Reference 46356896 /api/reference/46356896 39 10.1016/S0021-9258(18)68727-7 false true Reference 46356897 /api/reference/46356897 40 10.1126/science.307.5707.206b false true Reference 46356898 /api/reference/46356898 41 10.1074/jbc.M008057200 false true Reference 46356899 /api/reference/46356899 42 10.1016/S0024-3205(98)00354-3 false true Reference 46356900 /api/reference/46356900 43 false true /api/publication/34213267 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10067206"><a href="/gui2/?type=authors&mode=browse&sel=10067206" target="_blank">Janovicz Anna (<span class="authorship-author-name">Janovicz Anna</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073985"><a href="/gui2/?type=authors&mode=browse&sel=10073985" target="_blank">Majer Aliz (<span class="authorship-author-name">Majer Aliz</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020915"><a href="/gui2/?type=authors&mode=browse&sel=10020915" target="_blank">Kosztelnik Mónika (<span class="authorship-author-name">Kosztelnik Mónika</span> <span class="authorAux-mtmt"> Genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013679"><a href="/gui2/?type=authors&mode=browse&sel=10013679" target="_blank">Geiszt Miklós (<span class="authorship-author-name">Geiszt Miklós</span> <span class="authorAux-mtmt"> reaktiv oxigén származékok hatásainak vizsgálata</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chun Jerold </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Ishii Satoshi </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10046134"><a href="/gui2/?type=authors&mode=browse&sel=10046134" target="_blank">Tigyi Gábor József (<span class="authorship-author-name">Tigyi Gabor</span> <span class="authorAux-mtmt"> Lipid biokemia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009921"><a href="/gui2/?type=authors&mode=browse&sel=10009921" target="_blank">Benyó Zoltán (<span class="authorship-author-name">Benyó Zoltán</span> <span class="authorAux-mtmt"> Élettan és kórélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025626"><a href="/gui2/?type=authors&mode=browse&sel=10025626" target="_blank">Ruisanchez Éva ✉ (<span class="authorship-author-name">Ruisanchez Éva</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Transzlációs Medicina Intézet">TMI</span>/ELKH-SE Cerebrovaszkuláris és Neurokognitív Betegségek Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34213267" target="_blank">Autotaxin–lysophosphatidic acid receptor 5 axis evokes endothelial dysfunction via reactive oxygen species signaling</a></div> <div> <span class="journal-title">EXPERIMENTAL BIOLOGY AND MEDICINE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1535-3702">1535-3702</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1535-3699">1535-3699</a>)</span>: <span class="journal-volume">248</span> <span class="journal-issue">20</span> <span class="page"> pp 1887-1894 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1177/15353702231199081" target="_blank" href="https://doi.org/10.1177/15353702231199081"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001086876200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001086876200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85174050305" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85174050305"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37837357" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37837357&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34213267&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34213267</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, (K-125174) Támogató: NKFIH, (K-135683) Támogató: OTKA, (K-139230) Támogató: NKFIH, NKFIH(NVKP_16-1-2016-0042), (PD-132851) Támogató: OTKA, (2020-1.1.6-JÖVŐ-2021-00010), (2020-1.1.6-JOVO-2021-00013), (TKP2021-EGA-25) </div> <div class="lastModified">Utolsó módosítás: 2024.02.01. 10:27 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <div class="lockedBy">Központi kezelésű 2024.10.17. 18:46 Ladányi Gusztáv (MTMT API user, admin) Szendrei László (MTMT ellenőrzés, admin) </div> </div></div>