https://m2.mtmt.hu/ eng 2026-10-24 12:54 JournalArticle 34212082 VALIDATED true Funding Agency and Grant Number: Not applicable. Funding text: Not applicable. 0 false 2026-10-23T22:29:28.114+0000 2026-06-18T17:20:57.524+0000 2023-10-23T20:27:33.051+0000 true 10081959 Szalóky-Siki Ágnes /api/admin/10081959 Admin Ágnes Szalóky-Siki (SE_ÁOK_Transzlációs_Admin5_SZSÁ, admin) true 2026-06-18T17:20:57.389+0000 2026-01-26T08:26:47.868+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin Edit Csajbók (SE_KK_Admin5_CSE, admin) true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Papp, Márton true true /api/journal/33611 REVIEWED CRITICAL CARE 1364-8535 1466-609X true false 33611 false 33611 true 1364-8535 1466-609X Journal FOREIGN 27 1 394 394 15 2023 Appropriate antibiotic (AB) therapy remains a challenge in the intensive care unit (ICU). Procalcitonin (PCT)-guided AB stewardship could help optimize AB treatment and decrease AB-related adverse effects, but firm evidence is still lacking. Our aim was to compare the effects of PCT-guided AB therapy with standard of care (SOC) in critically ill patients.We searched databases CENTRAL, Embase and Medline. We included randomized controlled trials (RCTs) comparing PCT-guided AB therapy (PCT group) with SOC reporting on length of AB therapy, mortality, recurrent and secondary infection, ICU length of stay (LOS), hospital LOS or healthcare costs. Due to recent changes in sepsis definitions, subgroup analyses were performed in studies applying the Sepsis-3 definition. In the statistical analysis, a random-effects model was used to pool effect sizes.We included 26 RCTs (n = 9048 patients) in the quantitative analysis. In comparison with SOC, length of AB therapy was significantly shorter in the PCT group (MD - 1.79 days, 95% CI: -2.65, - 0.92) and was associated with a significantly lower 28-day mortality (OR 0.84, 95% CI: 0.74, 0.95). In Sepsis-3 patients, mortality benefit was more pronounced (OR 0.46 95% CI: 0.27, 0.79). Odds of recurrent infection were significantly higher in the PCT group (OR 1.36, 95% CI: 1.10, 1.68), but there was no significant difference in the odds of secondary infection (OR 0.81, 95% CI: 0.54, 1.21), ICU and hospital length of stay (MD - 0.67 days 95% CI: - 1.76, 0.41 and MD - 1.23 days, 95% CI: - 3.13, 0.67, respectively).PCT-guided AB therapy may be associated with reduced AB use, lower 28-day mortality but higher infection recurrence, with similar ICU and hospital length of stay. Our results render the need for better designed studies investigating the role of PCT-guided AB stewardship in critically ill patients. Funding 2032447 /api/funding/2032447 (K 138816) false true true 2023 true true true false true false GOLD 2026-10-24 true https://doi.org/10.1186/s13054-023-04677-2 62 0 62 61 1 62 62 56 57 60 60 59 59 61 1 0 62 61 62 61 0 4 4 Folyóiratcikk Journal Article 24 61 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 1 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 12 12 12 12 2025 0 19 19 19 19 2026 0 31 30 31 30 D1 false 10002007 false false false 2023-10-23T07:18:21.696+0000 Aneszteziológiai és Intenzív Terápiás Klinika (SE / AOK / K); Biostatisztika tanszék (ÁTE / GBI); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Pankreász Betegségek Intézete (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE) 9 52 6 10 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 110842375 /api/authorship/110842375 Papp, Márton [Papp, Márton (intenzív terápia), author] Centre for Translational Medicine (SU / KSZE) 1 0.1 true false false Author 10094584 /api/author/10094584 Márton Papp (intenzív terápia) Papp Márton true true Papp Márton true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 110842376 /api/authorship/110842376 Kiss, Nikolett [Kiss, Nikolett (Aneszteziológia), author] Department of Anesthesoiology and Intensiv Therapy (SU / FM / C); Department of Cardiology – Heart and Vascular C... (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 2 0.1 false false false Author 10027033 /api/author/10027033 Nikolett Kiss (Aneszteziológia) Kiss Nikolett true 10027033 true Kiss Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 110842377 /api/authorship/110842377 Baka, Máté 3 0.1 false false false Baka Máté true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 110842378 /api/authorship/110842378 Trásy, Domonkos [Trásy, Domonkos (Aneszteziológia é...), author] Centre for Translational Medicine (SU / KSZE) 4 0.1 false false false Author 10055105 /api/author/10055105 Domonkos Trásy (Aneszteziológia és intenzív terápia) Trásy Domonkos true 10055105 true Trásy Domonkos true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 110842379 /api/authorship/110842379 Zubek, László [Zubek, László (Aneszteziológia é...), author] Department of Anesthesoiology and Intensiv Therapy (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 5 0.1 false false false Author 10024610 /api/author/10024610 László Zubek (Aneszteziológia és Intenzív Terápia) Zubek László true 10024610 true Zubek László true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 110842380 /api/authorship/110842380 Fehérvári, Péter [Fehérvári, Péter (Biomatematika), author] Centre for Translational Medicine (SU / KSZE); Department of Biostatistics (UVMB / IEB) 6 0.1 false false false Author 10023284 /api/author/10023284 Péter Fehérvári (Biomatematika) Fehérvári Péter true 10023284 true Fehérvári Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 110842381 /api/authorship/110842381 Harnos, Andrea [Harnos, Andrea (Biostatisztika), author] Centre for Translational Medicine (SU / KSZE); Department of Biostatistics (UVMB / IEB) 7 0.1 false false false Author 10002007 /api/author/10002007 Andrea Harnos (Biostatisztika) Harnos Andrea true 10002007 true Harnos Andrea true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 110842382 /api/authorship/110842382 Turan, Caner [Turan, Caner (Anesthesia and In...), author] Department of Anesthesoiology and Intensiv Therapy (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 8 0.1 false false false Author 10077662 /api/author/10077662 Caner Turan (Anesthesia and Intensive Care) Turan Caner true true Turan Caner true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 110842383 /api/authorship/110842383 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE); Institute of Pancreatic Diseases (SU / FM / C) 9 0.1 false false false Author 10002629 /api/author/10002629 Péter Hegyi (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 110842384 /api/authorship/110842384 Molnár, Zsolt ✉ [Molnár, Zsolt (Klinikai orvostud...), author] Department of Anesthesoiology and Intensiv Therapy (SU / FM / C); Centre for Translational Medicine (SU / KSZE) 10 0.1 false true true Author 10001298 /api/author/10001298 Zsolt Molnár (Klinikai orvostudományok - aneszteziológia és intenzív terápia) Molnár Zsolt true 10001298 true Molnár Zsolt true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 24556715 /api/publicationidentifier/24556715 DOI: 10.1186/s13054-023-04677-2 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1186/s13054-023-04677-2 https://doi.org/10.1186/s13054-023-04677-2 false true PublicationIdentifier 25042969 /api/publicationidentifier/25042969 WoS: 001099563100002 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001099563100002 https://www.webofscience.com/wos/woscc/full-record/001099563100002 false true PublicationIdentifier 24588416 /api/publicationidentifier/24588416 Scopus: 85174306141 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85174306141 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85174306141 true true PublicationIdentifier 24556714 /api/publicationidentifier/24556714 PubMed: 37833778 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37833778 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37833778&dopt=Abstract false true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true SjrRating 11367721 /api/sjrrating/11367721 sjr:D1 (2023) Scopus - Critical Care and Intensive Care Medicine CRITICAL CARE 1364-8535 1466-609X 3 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2706 /api/classificationexternal/2706 Scopus - Critical Care and Intensive Care Medicine true 2706 true D1 DIRECT true true /api/publication/34212082 Papp Márton et al. Procalcitonin-guided antibiotic therapy may shorten length of treatment and may improve survival-a systematic review and meta-analysis. (2023) CRITICAL CARE 1364-8535 1466-609X 27 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10094584"><a href="/gui2/?type=authors&mode=browse&sel=10094584" target="_blank">Papp Márton (<span class="authorship-author-name">Papp Márton</span> <span class="authorAux-mtmt"> intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027033"><a href="/gui2/?type=authors&mode=browse&sel=10027033" target="_blank">Kiss Nikolett (<span class="authorship-author-name">Kiss Nikolett</span> <span class="authorAux-mtmt"> Aneszteziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Cardiovascular Center">Cardiovascular Center</span>/Department of Cardiology – Heart and Vascular Center; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Baka Máté </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055105"><a href="/gui2/?type=authors&mode=browse&sel=10055105" target="_blank">Trásy Domonkos (<span class="authorship-author-name">Trásy Domonkos</span> <span class="authorAux-mtmt"> Aneszteziológia és intenzív terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024610"><a href="/gui2/?type=authors&mode=browse&sel=10024610" target="_blank">Zubek László (<span class="authorship-author-name">Zubek László</span> <span class="authorAux-mtmt"> Aneszteziológia és Intenzív Terápia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023284"><a href="/gui2/?type=authors&mode=browse&sel=10023284" target="_blank">Fehérvári Péter (<span class="authorship-author-name">Fehérvári Péter</span> <span class="authorAux-mtmt"> Biomatematika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Élelmiszerlánc-biztonsági és Járványvédelmi Intézet">ÉBJI</span>/<span title="Institute of Economics and Biostatistics">IEB</span>/Department of Biostatistics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002007"><a href="/gui2/?type=authors&mode=browse&sel=10002007" target="_blank">Harnos Andrea (<span class="authorship-author-name">Harnos Andrea</span> <span class="authorAux-mtmt"> Biostatisztika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="University of Veterinary Medicine Budapest">UVMB</span>/<span title="Élelmiszerlánc-biztonsági és Járványvédelmi Intézet">ÉBJI</span>/<span title="Institute of Economics and Biostatistics">IEB</span>/Department of Biostatistics</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10077662"><a href="/gui2/?type=authors&mode=browse&sel=10077662" target="_blank">Turan Caner (<span class="authorship-author-name">Turan Caner</span> <span class="authorAux-mtmt"> Anesthesia and Intensive Care</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001298"><a href="/gui2/?type=authors&mode=browse&sel=10001298" target="_blank">Molnár Zsolt ✉ (<span class="authorship-author-name">Molnár Zsolt</span> <span class="authorAux-mtmt"> Klinikai orvostudományok - aneszteziológia és i...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Anesthesoiology and Intensiv Therapy; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34212082" target="_blank">Procalcitonin-guided antibiotic therapy may shorten length of treatment and may improve survival-a systematic review and meta-analysis</a></div> <div> <span class="journal-title">CRITICAL CARE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1364-8535">1364-8535</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1466-609X">1466-609X</a>)</span>: <span class="journal-volume">27</span> <span class="journal-issue">1</span> <span class="page"> Paper 394. 15 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1186/s13054-023-04677-2" target="_blank" href="https://doi.org/10.1186/s13054-023-04677-2"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001099563100002" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001099563100002"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85174306141" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85174306141"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37833778" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37833778&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Critical Care and Intensive Care Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 62</span> | Independent citation: 61 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 56 | Number of citations in Scopus:&nbsp;57 | WoS/Scopus assigned:&nbsp;60 | Number of citations with DOI:&nbsp;62 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34212082&sort=publishedYear,desc&sort=title"> Number of cited publications: 4 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34212082</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K 138816) </div> <div class="lastModified">Last Modified: 2026.06.18. 19:20 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Not applicable. Funding text: Not applicable.</pre> </div></div>