https://m2.mtmt.hu/ hun 2026-08-26 14:03 JournalArticle 3420895 VALIDATED true : IRELAND Agricultural Biotechnology Institute, Szent-Györgyi 4, Gödöllő, H-2100, Hungary University Pannonia Georgikon, Festetics 7, Keszthely, 8360, Hungary Cited By :12 Export Date: 9 September 2020 CODEN: PLSCE Correspondence Address: Silhavy, D.; Agricultural Biotechnology Institute, Szent-Györgyi 4, Hungary; email: silhavy@abc.hu 0 2018-09-20T22:20:09.000+0000 false 3420895 2026-08-17T13:10:10.730+0000 2024-05-13T07:59:23.960+0000 2018-09-20T07:06:10.000+0000 true 10064621 Horváth Sára Andrea /api/admin/10064621 Admin true 10064621 2025-03-24T14:05:44.550+0000 2019-11-11T21:17:36.187+0000 true 565 WoS import /api/admin/565 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szadeczky-Kardoss, I The No-go decay system degrades plant mRNAs that contain a long A-stretch in the coding region true true /api/journal/3714 REVIEWED true false 3714 false 3714 true 0168-9452 1873-2259 Journal FOREIGN 275 19 27 19 9 2018 RNA quality control systems identify and degrade aberrant mRNAs, thereby preventing the accumulation of faulty proteins. Non-stop decay (NSD) and No-go decay (NGD) are closely related RNA quality control systems that act during translation. NSD degrades mRNAs lacking a stop codon, while NGD recognizes and decays mRNAs that contain translation elongation inhibitory structures. NGD has been intensively studied in yeast and animals but it has not been described in plants yet. In yeast, NGD is induced if the elongating ribosome is stalled by a strong inhibitory structure. Then, the mRNA is cleaved by an unknown nuclease and the cleavage fragments are degraded. Here we show that NGD also operates in plant. We tested several potential NGD cis-elements and found that in plants, unlike in yeast, only long A-stretches induce NGD. These long A-stretches trigger endonucleolytic cleavage, and then the 5' fragments are degraded in a Pelota-, HBS1- and SKI2- dependent manner, while XRN4 eliminates the 3' fragment. We also show that plant NGD operates gradually, the longer the A stretch, the more efficient the cleavage. Our data suggest that mechanistically NGD is conserved in eukaryotes, although the NGD inducing cis-elements could be different. Moreover, we found that Arabidopsis AtPelota1 functions in both NGD and NSD, while AtPelota2 represses these quality control systems. The function of plant NGD will be discussed. 2018 807868 true true true false true false NONE 2026-08-17 false 43 0 38 36 0 38 38 38 31 38 38 36 36 41 2 0 43 41 38 36 0 8 8 Folyóiratcikk Journal Article 24 38 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 4 Egyéb Miscellaneous 29 1 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2019 0 6 6 6 6 2020 0 7 7 7 7 2021 0 6 5 6 5 2022 0 3 3 3 3 2023 0 7 7 7 7 2024 0 4 4 4 4 2025 0 6 5 6 5 2026 0 4 4 4 4 D1 false 10001287,10002575 false false false 2018-09-20T07:07:33.000+0000 2018-09-20T07:07:32.000+0000 Növénytudományi és Biotechnológiai Tanszék (PE / GK) 5 32 1 5 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 10493265 /api/authorship/10493265 1 0.2 true false Author 10049725 /api/author/10049725 Szádeczky-Kardoss István true 10049725 true Szadeczky-Kardoss I true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 29202702 true PersonAuthorship 10493266 /api/authorship/10493266 2 0.2 false false Author 10073902 /api/author/10073902 Gál Luca true true Gal L true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 29202701 true PersonAuthorship 10493267 /api/authorship/10493267 3 0.2 false false Author 10063788 /api/author/10063788 Auber Andor true 10063788 true Auber A true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 29202700 true PersonAuthorship 10493268 /api/authorship/10493268 4 0.2 false false Author 10002575 /api/author/10002575 Taller János true 10002575 true Taller J true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 29202699 true PersonAuthorship 10493269 /api/authorship/10493269 5 0.2 false true Author 10001287 /api/author/10001287 Silhavy Dániel true 10001287 true Silhavy D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false 29202698 true PublicationIdentifier 1327715 /api/publicationidentifier/1327715 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true false IDENTICAL 10.1016/j.plantsci.2018.07.008 https://doi.org/10.1016/j.plantsci.2018.07.008 false 1836486 true PublicationIdentifier 1327714 /api/publicationidentifier/1327714 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS 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true 1489732 true Keyword 1489733 /api/keyword/1489733 true 1489733 true Keyword 1489734 /api/keyword/1489734 true 1489734 true SjrRating 10736945 /api/sjrrating/10736945 16 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1102 /api/classificationexternal/1102 true 1102 true D1 DIRECT true true /api/publication/3420895 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10049725"><a href="/gui2/?type=authors&mode=browse&sel=10049725" target="_blank">Szadeczky-Kardoss I (<span class="authorship-author-name">Szádeczky-Kardoss István</span> <span class="authorAux-mtmt"> Molekuláris növénybiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10073902"><a href="/gui2/?type=authors&mode=browse&sel=10073902" target="_blank">Gal L (<span class="authorship-author-name">Gál Luca</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063788"><a href="/gui2/?type=authors&mode=browse&sel=10063788" target="_blank">Auber A (<span class="authorship-author-name">Auber Andor</span> <span class="authorAux-mtmt"> Növényi molekuláris biológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002575"><a href="/gui2/?type=authors&mode=browse&sel=10002575" target="_blank">Taller J (<span class="authorship-author-name">Taller János</span> <span class="authorAux-mtmt"> Növény-biotechnológia</span>) </a> </span> <span class="author-affil"><span title="Pannon Egyetem">PE</span>/<span title="Georgikon Kar">GK</span>/Növénytudományi és Biotechnológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001287"><a href="/gui2/?type=authors&mode=browse&sel=10001287" target="_blank">Silhavy D (<span class="authorship-author-name">Silhavy Dániel</span> <span class="authorAux-mtmt"> Növényi molekuláris biológia</span>) </a> </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;3420895" target="_blank">The No-go decay system degrades plant mRNAs that contain a long A-stretch in the coding region</a></div> <div> <span class="journal-title">PLANT SCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0168-9452">0168-9452</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-2259">1873-2259</a>)</span>: <span class="journal-volume">275</span> <span class="page"> pp 19-27 </span> <span class="year">(2018)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier 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indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Plant Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Genetics&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 43</span> | Független: 41 | Függő: 2 | Nem jelölt: 0 | WoS jelölt: 38 | Scopus jelölt:&nbsp;31 | WoS/Scopus jelölt:&nbsp;38 | DOI jelölt:&nbsp;38 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;3420895&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 8 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 3420895</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> <span class="oldId">Régi azonosító: 3420895</span> | Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">WOS</span> </div> <div class="lastModified">Utolsó módosítás: 2024.05.13. 09:59 Sonnevend Kinga (SE_AOK_Adm5_Élet_kutcsop, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: : IRELAND Agricultural Biotechnology Institute, Szent-Györgyi 4, Gödöllő, H-2100, Hungary University Pannonia Georgikon, Festetics 7, Keszthely, 8360, Hungary Cited By :12 Export Date: 9 September 2020 CODEN: PLSCE Correspondence Address: Silhavy, D.; Agricultural Biotechnolog...</pre> </div></div>