https://m2.mtmt.hu/ hun 2026-09-21 19:39 JournalArticle 34199166 VALIDATED true Bolyai János Kutatási Ösztöndíj (BO/00582/22/8) Laboratory of Functional Genomics, HUN-REN Biological Research Centre, Szeged, Hungary PhD School in Biology, University of Szeged, Szeged, Hungary Csongrád County Hospital of Chest Diseases, Deszk, Hungary Department of Pathology, University of Szeged, Szeged, Hungary Department of Surgery, University of Szeged, Szeged, Hungary Avicor Ltd, Szeged, Hungary Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary CS-Smartlab Devices Ltd, Kozármisleny, Hungary Export Date: 7 November 2023 Correspondence Address: Puskás, L.G.; Laboratory of Functional Genomics, Hungary; email: laszlo@avidinbiotech.com Correspondence Address: Szebeni, G.J.; Laboratory of Functional Genomics, Hungary; email: szebeni.gabor@brc.hu Funding details: Magyar Tudományos Akadémia, MTA, BO/00582/22/8, ÚNKP-23-5 -SZTE-694 Funding details: Nemzeti Kutatási Fejlesztési és Innovációs Hivatal, NKFI Funding details: Nemzeti Kutatási, Fejlesztési és Innovaciós Alap, NKFIA, C1764415 Funding details: Innovációs és Technológiai Minisztérium Funding details: National Research, Development and Innovation Office Funding text 1: This research was funded by the 2020‐1.1.6‐JÖVŐ−2021‐00003 and 142877 FK22, KFI_16-1-2017-0105 grant from the National Research, Development, and Innovation Office (NKFI), Hungary. This work was supported by the János Bolyai Research Scholarship of the Hungarian Academy of Sciences BO/00582/22/8 (GS) and by the by the ÚNKP-23-5 -SZTE-694 New National Excellence Program of the Ministry for Innovation and Technology (GS). This manuscript was supported by the KDP-2021 Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund for NG (C1764415). 0 false 2026-09-13T17:53:41.208+0000 2026-05-25T18:49:53.423+0000 2023-10-16T12:13:45.483+0000 true 10045852 Patkósné Hanesz Andrea /api/admin/10045852 Admin Patkósné Hanesz Andrea (SZBK-4-es admin) true 10045852 2025-06-24T18:13:48.299+0000 2026-05-25T18:49:53.733+0000 true 10013962 Vasvari Lilian /api/admin/10013962 Admin Vasvari Lilian (MTMT Központ, admin) true 10013962 Admin 10014568 /api/admin/10014568 Vándor Andrea (VA, admin) Vándor Andrea true 10014568 true 2024-04-03T13:48:46.080+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Neuperger, Patrícia true true /api/journal/10023324 REVIEWED FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 true false 10023324 false 10023324 true 1664-3224 1664-3224 Journal FOREIGN 14 1243233 1243233 14 2023 Introduction: The effect of platinum-based chemotherapy (Chem.) and second- or multiple- line immune checkpoint PD-1 blocking therapy by Nivolumab or Pembrolizumab (ICI) was assayed in the peripheral blood of non-small cell lung cancer (NSCLC) patients. Methods: Flow cytometry was used to detect NSCLC-related antigen binding IgG antibodies. The Luminex MagPix multiplex bead-based cytokine/chemokine detecting system was used to quantitatively measure 17 soluble markers in the plasma samples. Single-cell mass cytometry was applied for the immunophenotyping of peripheral leukocytes. Results: The incubation of patient derived plasma with human NSCLC tumor cell lines, such as A549, H1975, and H1650, detected NSCLC-specific antibodies reaching a maximum of up to 32% reactive IgG-positive NSCLC cells. The following markers were detected in significantly higher concentration in the plasma of Chem. group versus healthy non-smoker and smoker controls: BTLA, CD27, CD28, CD40, CD80, CD86, GITRL, ICOS, LAG-3, PD-1, PD-L1, and TLR-2. The following markers were detected in significantly higher concentration in the plasma of ICI group versus healthy non-smoker and smoker controls: CD27, CD28, CD40, GITRL, LAG-3, PD-1, PD-L1, and TLR-2. We showed the induction of CD69 and IL-2R on CD4+ CD25+ T-cells upon chemotherapy; the exhaustion of one CD8+ T-cell population was detected by the loss of CD127 and a decrease in CD27. CD19+CD20+, CD79B+, or activated B-cell subtypes showed CD69 increase and downregulation of BTLA, CD27, and IL-2R in NSCLC patients following chemotherapy or ICI. Discussion: Peripheral immunophenotype caused by chemotherapy or PD-1 blocking was shown in the context of advanced NSCLC. true 2023 true true true false true false GOLD 2026-09-13 true https://real.mtak.hu/190164 16 0 16 4 12 16 16 15 16 16 16 4 4 4 12 0 16 4 16 4 0 11 11 Folyóiratcikk Journal Article 24 16 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 0 1 0 2024 0 6 0 6 0 2025 0 6 4 6 4 2026 0 3 0 3 0 Q1 false 10025339 false false false 2023-10-15T13:51:32.314+0000 Biológia Doktori Iskola (SZTE / DI); Genetikai Intézet (HRN SZBK); Központi Laboratóriumok (HRN SZBK); Pathologiai Intézet (SZTE / SZAOK); Sebészeti Klinika (SZTE / SZAOK); Tüdőgyógyászati Tanszék (SZTE / SZAOK); Élettani, Szervezettani és Idegtudományi Tanszék (SZTE / TTIK / BI) 9 20 7 9 0 true 10014568 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 110355719 /api/authorship/110355719 Neuperger, Patrícia [Neuperger, Patricia (immunológia), szerző] Genetikai Intézet (HRN SZBK); Központi Laboratóriumok (HRN SZBK); Biológia Doktori Iskola (SZTE / DI) 1 0.111 true false false Author 10071441 /api/author/10071441 Neuperger Patricia (immunológia) Neuperger Patricia true true Neuperger Patrícia true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110355720 /api/authorship/110355720 Szalontai, Klára [Szalontai, Klára Margit (pulmonológia és k...), szerző] Tüdőgyógyászati Tanszék (SZTE / SZAOK) 2 0.11111111 false false false Author 10028612 /api/author/10028612 Szalontai Klára Margit (pulmonológia és klinikai onkológia) Szalontai Klára Margit true 10028612 true Szalontai Klára true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110355721 /api/authorship/110355721 Gémes, Nikolett [Gémes, Nikolett (immunológia), szerző] Genetikai Intézet (HRN SZBK); Központi Laboratóriumok (HRN SZBK); Biológia Doktori Iskola (SZTE / DI) 3 0.111 false false false Author 10081633 /api/author/10081633 Gémes Nikolett (immunológia) Gémes Nikolett true true Gémes Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110355722 /api/authorship/110355722 Balog, József Á. 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(2023) FRONTIERS IN IMMUNOLOGY 1664-3224 1664-3224 14<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10071441"><a href="/gui2/?type=authors&mode=browse&sel=10071441" target="_blank">Neuperger Patrícia (<span class="authorship-author-name">Neuperger Patricia</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet; <span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Központi Laboratóriumok; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Biológia Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028612"><a href="/gui2/?type=authors&mode=browse&sel=10028612" target="_blank">Szalontai Klára (<span class="authorship-author-name">Szalontai Klára Margit</span> <span class="authorAux-mtmt"> pulmonológia és klinikai onkológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Tüdőgyógyászati Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081633"><a href="/gui2/?type=authors&mode=browse&sel=10081633" target="_blank">Gémes Nikolett (<span class="authorship-author-name">Gémes Nikolett</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet; <span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Központi Laboratóriumok; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Doktori Iskolák">DI</span>/Biológia Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065273"><a href="/gui2/?type=authors&mode=browse&sel=10065273" target="_blank">Balog József Á. (<span class="authorship-author-name">Balog József Ágoston</span> <span class="authorAux-mtmt"> immunológia, sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet; <span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Központi Laboratóriumok</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009640"><a href="/gui2/?type=authors&mode=browse&sel=10009640" target="_blank">Tiszlavicz László (<span class="authorship-author-name">Tiszlavicz László</span> <span class="authorAux-mtmt"> Pathológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Pathologiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028656"><a href="/gui2/?type=authors&mode=browse&sel=10028656" target="_blank">Furák József (<span class="authorship-author-name">Furák József</span> <span class="authorAux-mtmt"> sebészet, mellkassebészet</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Sebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010110"><a href="/gui2/?type=authors&mode=browse&sel=10010110" target="_blank">Lázár György (<span class="authorship-author-name">Lázár György ifj</span> <span class="authorAux-mtmt"> Klinikai orvostudományok</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Szent-Györgyi Albert Orvostudományi Kar">SZAOK</span>/Sebészeti Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010041"><a href="/gui2/?type=authors&mode=browse&sel=10010041" target="_blank">Puskás László G.^** ✉ (<span class="authorship-author-name">Puskás László</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet; <span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Központi Laboratóriumok</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025339"><a href="/gui2/?type=authors&mode=browse&sel=10025339" target="_blank">Szebeni Gábor J. ✉ (<span class="authorship-author-name">Szebeni Gábor</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Genetikai Intézet; <span title="Szegedi Biológiai Kutatóközpont">SZBK</span>/Központi Laboratóriumok; <span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Természettudományi és Informatikai Kar">TTIK</span>/<span title="Biológia Intézet">BI</span>/Élettani, Szervezettani és Idegtudományi Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34199166" target="_blank">Single-cell mass cytometric analysis of peripheral immunity and multiplex plasma marker profiling of non-small cell lung cancer patients receiving PD-1 targeting immune checkpoint inhibitors in comparison with platinum-based chemotherapy</a></div> <div> <span class="journal-title">FRONTIERS IN IMMUNOLOGY</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1664-3224">1664-3224</a>)</span>: <span class="journal-volume">14</span> <span class="page"> Paper 1243233. 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fimmu.2023.1243233" target="_blank" href="https://doi.org/10.3389/fimmu.2023.1243233"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001091300600001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001091300600001"> WoS </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:black" title="190164" target="_blank" href="https://real.mtak.hu/190164"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175369966" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175369966"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37901220" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37901220&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.frontiersin.org/articles/10.3389/fimmu.2023.1243233/full" target="_blank" href="https://www.frontiersin.org/articles/10.3389/fimmu.2023.1243233/full"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="28500" target="_blank" href="http://publicatio.bibl.u-szeged.hu/28500"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 16</span> | Független: 4 | Függő: 12 | Nem jelölt: 0 | WoS jelölt: 15 | Scopus jelölt:&nbsp;16 | WoS/Scopus jelölt:&nbsp;16 | DOI jelölt:&nbsp;16 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34199166&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 11 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34199166</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Utolsó módosítás: 2026.05.25. 20:49 Vasvari Lilian (MTMT Központ, admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.03. 15:48 Vándor Andrea (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Bolyai János Kutatási Ösztöndíj (BO/00582/22/8) Laboratory of Functional Genomics, HUN-REN Biological Research Centre, Szeged, Hungary PhD School in Biology, University of Szeged, Szeged, Hungary Csongrád County Hospital of Chest Diseases, Deszk, Hungary Department of Pathology, University of Szeged, Szeged, Hunga...</pre> </div></div>