https://m2.mtmt.hu/ hun 2026-09-22 14:37 JournalArticle 34175360 APPROVED true 0 false 2026-05-23T06:19:14.802+0000 2024-02-15T12:35:22.347+0000 2023-10-04T20:28:42.889+0000 true 10068186 Jezsó Bálint /api/author/10068186 Author Jezsó Bálint (Sejtbiológia) true 2026-02-18T11:58:40.645+0000 Admin 10014568 /api/admin/10014568 Vándor Andrea (VA, admin) Vándor Andrea true 10014568 true 2024-04-04T10:42:03.166+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Mózner, Orsolya true true /api/journal/10041705 REVIEWED MEMBRANES (BASEL) 2077-0375 true false 10041705 false 10041705 true 2077-0375 Journal FOREIGN 13 10 822 822 14 2023 The human ABCG2 multidrug transporter plays a crucial role in the absorption and excretion of xeno- and endobiotics, contributes to cancer drug resistance and the development of gout. In this work, we have analyzed the effects of selected variants, residing in a structurally unresolved cytoplasmic region (a.a. 354–367) of ABCG2 on the function and trafficking of this protein. A cluster of four lysines (K357–360) and the phosphorylation of a threonine (T362) residue in this region have been previously suggested to significantly affect the cellular fate of ABCG2. Here, we report that the naturally occurring K360del variant in human cells increased ABCG2 plasma membrane expression and accelerated cellular trafficking. The variable alanine replacements of the neighboring lysines had no significant effect on transport function, and the apical localization of ABCG2 in polarized cells has not been altered by any of these mutations. Moreover, in contrast to previous reports, we found that the phosphorylation-incompetent T362A, or the phosphorylation-mimicking T362E variants in this loop had no measurable effects on the function or expression of ABCG2. Molecular dynamics simulations indicated an increased mobility of the mutant variants with no major effects on the core structure of the protein. These results may help to decipher the potential role of this unstructured region within this transporter. Funding 2033093 /api/funding/2033093 (NKFIH-K-128123) Támogató: NKFIH false true Funding 2033094 /api/funding/2033094 (K127961) Támogató: NKFIH false true Funding 2033095 /api/funding/2033095 (K137610) false true Funding 2033096 /api/funding/2033096 (KDP-1017403) false true true 2023 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/membranes13100822 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 Q2 false 1241938 false false false 2023-11-02T14:40:37.792+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Biokémiai Tanszék (ELTE / TTK / Bio_I); Doktori Iskola (SE); Enzimológiai Intézet (TTK) 9 46 4 11 0 true 10014568 Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 110179649 /api/authorship/110179649 Mózner, Orsolya [Mózner, Orsolya (biomembrán), szerző] Enzimológiai Intézet (TTK); Doktori Iskola (SE) 1 0.091 true false false Author 10073889 /api/author/10073889 Mózner Orsolya (biomembrán) Mózner Orsolya true true Mózner Orsolya true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179650 /api/authorship/110179650 Zámbó, Boglárka [Zámbó, Boglárka (molekuláris biológia), szerző] Enzimológiai Intézet (TTK) 2 0.091 false false false Author 10053932 /api/author/10053932 Zámbó Boglárka (molekuláris biológia) Zámbó Boglárka true 10053932 true Zámbó Boglárka true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179651 /api/authorship/110179651 Bartos, Zsuzsa [Bartos, Zsuzsa (molekuláris biológia), szerző] Enzimológiai Intézet (TTK) 3 0.091 false false false Author 10054127 /api/author/10054127 Bartos Zsuzsa (molekuláris biológia) Bartos Zsuzsa true 10054127 true Bartos Zsuzsa true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179652 /api/authorship/110179652 Gergely, Anna 4 0.09090909 false false false Gergely Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179653 /api/authorship/110179653 Szabó, Kata Sára 5 0.09090909 false false false Szabó Kata Sára true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179654 /api/authorship/110179654 Jezsó, Bálint [Jezsó, Bálint (Sejtbiológia), szerző] Enzimológiai Intézet (TTK); Biokémiai Tanszék (ELTE / TTK / Bio_I) 6 0.091 false false false Author 10068186 /api/author/10068186 Jezsó Bálint (Sejtbiológia) Jezsó Bálint true true Jezsó Bálint true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179655 /api/authorship/110179655 Telbisz, Ágnes [Telbisz, Ágnes Mária (Biomembrán), szerző] Enzimológiai Intézet (TTK) 7 0.091 false false false Author 10027670 /api/author/10027670 Telbisz Ágnes Mária (Biomembrán) Telbisz Ágnes Mária true 10027670 true Telbisz Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179656 /api/authorship/110179656 Várady, György [Várady, György (Membránbiológia), szerző] Enzimológiai Intézet (TTK) 8 0.09090909 false false false Author 10015754 /api/author/10015754 Várady György (Membránbiológia) Várady György true 10015754 true Várady György true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179657 /api/authorship/110179657 Homolya, László [Homolya, László (Molekuláris sejtb...), szerző] Enzimológiai Intézet (TTK) 9 0.091 false false false Author 10010446 /api/author/10010446 Homolya László (Molekuláris sejtbiológia) Homolya László true 10010446 true Homolya László true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179658 /api/authorship/110179658 Hegedűs, Tamás ✉ [Hegedűs, Tamás (bioinformatika, b...), szerző] Biofizikai és Sugárbiológiai Intézet (SE / AOK / I) 10 0.091 false false true Author 10015687 /api/author/10015687 Hegedűs Tamás (bioinformatika, biofizika) Hegedűs Tamás true 10015687 true Hegedűs Tamás true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 110179659 /api/authorship/110179659 Sarkadi, Balázs ✉ [Sarkadi, Balázs (biofizika), szerző] Enzimológiai Intézet (TTK); Doktori Iskola (SE) 11 0.091 false true true Author 1241938 /api/author/1241938 Sarkadi Balázs (biofizika) Sarkadi Balázs true 1241938 true Sarkadi Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24459299 /api/publicationidentifier/24459299 DOI: 10.3390/membranes13100822 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/membranes13100822 https://doi.org/10.3390/membranes13100822 false true PublicationIdentifier 24891258 /api/publicationidentifier/24891258 WoS: 001095372000001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001095372000001 https://www.webofscience.com/wos/woscc/full-record/001095372000001 true true PublicationIdentifier 24632892 /api/publicationidentifier/24632892 Scopus: 85175065302 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85175065302 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175065302 false true PublicationIdentifier 24711226 /api/publicationidentifier/24711226 PubMed: 37887994 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37887994 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37887994&dopt=Abstract false true SjrRating 11361967 /api/sjrrating/11361967 sjr:Q2 (2023) Scopus - Chemical Engineering (miscellaneous) MEMBRANES (BASEL) 2077-0375 113 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1501 /api/classificationexternal/1501 Scopus - Chemical Engineering (miscellaneous) true 1501 true Q2 DIRECT true true Reference 45660330 /api/reference/45660330 1. 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(2023) MEMBRANES (BASEL) 2077-0375 13 10<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073889"><a href="/gui2/?type=authors&mode=browse&sel=10073889" target="_blank">Mózner Orsolya (<span class="authorship-author-name">Mózner Orsolya</span> <span class="authorAux-mtmt"> biomembrán</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053932"><a href="/gui2/?type=authors&mode=browse&sel=10053932" target="_blank">Zámbó Boglárka (<span class="authorship-author-name">Zámbó Boglárka</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10054127"><a href="/gui2/?type=authors&mode=browse&sel=10054127" target="_blank">Bartos Zsuzsa (<span class="authorship-author-name">Bartos Zsuzsa</span> <span class="authorAux-mtmt"> molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gergely Anna </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Szabó Kata Sára </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10068186"><a href="/gui2/?type=authors&mode=browse&sel=10068186" target="_blank">Jezsó Bálint (<span class="authorship-author-name">Jezsó Bálint</span> <span class="authorAux-mtmt"> Sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Biokémiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027670"><a href="/gui2/?type=authors&mode=browse&sel=10027670" target="_blank">Telbisz Ágnes (<span class="authorship-author-name">Telbisz Ágnes Mária</span> <span class="authorAux-mtmt"> Biomembrán</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015754"><a href="/gui2/?type=authors&mode=browse&sel=10015754" target="_blank">Várady György (<span class="authorship-author-name">Várady György</span> <span class="authorAux-mtmt"> Membránbiológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010446"><a href="/gui2/?type=authors&mode=browse&sel=10010446" target="_blank">Homolya László (<span class="authorship-author-name">Homolya László</span> <span class="authorAux-mtmt"> Molekuláris sejtbiológia</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10015687"><a href="/gui2/?type=authors&mode=browse&sel=10015687" target="_blank">Hegedűs Tamás ✉ (<span class="authorship-author-name">Hegedűs Tamás</span> <span class="authorAux-mtmt"> bioinformatika, biofizika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Biofizikai és Sugárbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1241938"><a href="/gui2/?type=authors&mode=browse&sel=1241938" target="_blank">Sarkadi Balázs ✉ (<span class="authorship-author-name">Sarkadi Balázs</span> <span class="authorAux-mtmt"> biofizika</span>) </a> </span> <span class="author-affil"><span title="Természettudományi Kutatóközpont">TTK</span>/Enzimológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34175360" target="_blank">Expression, Function and Trafficking of the Human ABCG2 Multidrug Transporter Containing Mutations in an Unstructured Cytoplasmic Loop</a></div> <div> <span class="journal-title">MEMBRANES (BASEL)</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2077-0375">2077-0375</a>)</span>: <span class="journal-volume">13</span> <span class="journal-issue">10</span> <span class="page"> Paper 822. 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/membranes13100822" target="_blank" href="https://doi.org/10.3390/membranes13100822"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001095372000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001095372000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85175065302" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85175065302"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37887994" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37887994&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemical Engineering (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Filtration and Separation&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Process Chemistry and Technology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34175360&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 9 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34175360</span> | <span class="status-data status-APPROVED"> Nyilvános </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NKFIH-K-128123) Támogató: NKFIH, (K127961) Támogató: NKFIH, (K137610), (KDP-1017403) </div> <div class="lastModified">Utolsó módosítás: 2024.02.15. 13:35 Sonnevend Kinga (SE_AOK_Adm5_Élet_kutcsop, admin) </div> <div class="lockedBy">Központi kezelésű 2024.04.04. 12:42 Vándor Andrea (VA, admin) </div> </div></div>