Background: The HEcoPerMed consortium developed a methodological guidance for the
harmonization and improvement of economic evaluations in personalized medicine. Materials
& methods: In three therapeutic areas, health economic models were developed to scrutinize
the recommendations of the guidance. Results: Altogether, 20 of the 23 recommendations
of the guidance were addressed by the models. Seven recommendations were applied in
all studies, six in two of the studies and seven in one of the studies. Recommendations
with an essential role on the final conclusions of the analyses were identified in
each study. Conclusion: The guidance was found to be best used as a tool to identify
and prioritize issues, verify solutions and justify decisions during the economic
analysis of personalized interventions.
