https://m2.mtmt.hu/ hun 2026-10-25 03:48 JournalArticle 34163139 VALIDATED true Cited By :1 Export Date: 11 December 2024 Correspondence Address: Levine, M.; Department of Periodontology, United States; email: martin-levine@ouhsc.edu Chemicals/CAS: adenine, 22177-51-1, 2922-28-3, 73-24-5; doxribtimine, 50-89-5; lysine, 56-87-1, 6899-06-5, 70-54-2; neutrophil collagenase Funding text 1: Zsolt M. Lohinai was supported by MinDent 1987 Ltd, and with Anna Földes by the Hungarian Human Resources Development Operational Program (EFOP-3.6.2-16-2017-00006), and the Thematic Excellence Program (2020-4.1.1.-TKP2020) of the Ministry for Innovation and Technology in Hungary within the framework of the Therapy Thematic Program at Semmelweis University. Kasidid Ruksakiet was supported by a Predoctoral Scholarship from Semmelweis University (EFOP-3.6.3-VEKOP-16-2017-00009). 0 false 2026-10-23T20:44:33.655+0000 2024-02-11T12:35:30.606+0000 2023-09-28T13:30:03.827+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-07-09T09:41:12.368+0000 2024-02-11T12:35:30.869+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Lohinai, Zsolt M. Genetic Control of GCF Exudation: Innate Immunity Genes and Periodontitis Susceptibility true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 18 14249 14249 17 2023 Chronic periodontitis is a bacterial infection associated with dentally adherent biofilm (plaque) accumulation and age-related comorbidities. The disease begins as an inflammatory exudate from gingival margins, gingival crevicular fluid (GCF) in response to biofilm lysine. After a week of experimental gingivitis (no oral hygiene), biofilm lysine concentration was linearly related to biofilm accumulation (plaque index) but to GCF as an arch-shaped double curve which separated 9 strong from 6 weak GCF responders (hosts). Host DNA was examined for single nucleotide polymorphisms (SNPs) of alleles reported in 7 periodontitis-associated genes. Across all 15 hosts, an adenine SNP (A) at IL1B-511 (rs16944), was significant for strong GCF (Fisher’s exact test, p < 0.05), and a thymidine SNP (T) at IL1B+3954 (rs1143634) for weak GCF provided 2 hosts possessing IL6-1363(T), rs2069827, were included. The phenotype of IL1B+3954(T) was converted from weak to strong in one host, and of the non-T allele from strong to weak in the other (specific epistasis, Fisher’s exact test, p < 0.01). Together with homozygous alternate or reference SNPs at IL10-1082 or CD14-260 in 4 hosts, all hosts were identified as strong or weak GCF responders. The GCF response is therefore a strong or weak genetic trait that indicates strong or weak innate immunity in EG and controllable or uncontrollable periodontal disease, dental implant survival and late-life comorbidities. 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(<span class="authorship-author-name">Lohinai Zsolt</span> <span class="authorAux-mtmt"> Konzerváló fogászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Helyreállító Fogászati és Endodonciai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064954"><a href="/gui2/?type=authors&mode=browse&sel=10064954" target="_blank">Ruksakiet Kasidid (<span class="authorship-author-name">Ruksakiet Kasidid</span> <span class="authorAux-mtmt"> orálbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Helyreállító Fogászati és Endodonciai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="105"><a href="/gui2/?type=authors&mode=browse&sel=105" target="_blank">Földes Anna (<span class="authorship-author-name">Földes Anna</span> <span class="authorAux-mtmt"> Molekulár biológia, Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Fogorvostudományi Kar">FOK</span>/Orálbiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10009579"><a href="/gui2/?type=authors&mode=browse&sel=10009579" target="_blank">Dinya Elek (<span class="authorship-author-name">Dinya Elek</span> <span class="authorAux-mtmt"> Orvosi biometria</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Egészségügyi Közszolgálati Kar">EKK</span>/Digitális Egészségtudományi Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Levine Martin ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34163139" target="_blank">Genetic Control of GCF Exudation: Innate Immunity Genes and Periodontitis Susceptibility</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">18</span> <span class="page"> Paper 14249. 17 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms241814249" target="_blank" href="https://doi.org/10.3390/ijms241814249"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001145362100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001145362100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85173023366" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85173023366"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37762554" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37762554&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 1 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34163139&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34163139</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">RIS-Egyéb</span> </div> <div class="funder"> EMBERI ERŐFORRÁS FEJLESZTÉSI OPERATÍV PROGRAM (EFOP)(EFOP-3.6.2-162017-00006) Támogató: NKFIH, Tématerületi Kiválósági Program(2020-4.1.1.-TKP2020), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP </div> <div class="lastModified">Utolsó módosítás: 2024.02.11. 13:35 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Cited By :1 Export Date: 11 December 2024 Correspondence Address: Levine, M.; Department of Periodontology, United States; email: martin-levine@ouhsc.edu Chemicals/CAS: adenine, 22177-51-1, 2922-28-3, 73-24-5; doxribtimine, 50-89-5; lysine, 56-87-1, 6899-06-5, 70-54-2; neutrophil collagenase Funding ...</pre> </div></div>