https://m2.mtmt.hu/ eng 2026-04-17 04:57 JournalArticle 34153931 VALIDATED true Funding Agency and Grant Number: Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00451/20/5]; New National Excellence Program of the Ministry for Innovation and Technology [UNKP-21-5-SE-3, UNKP-21-3-II-SE-13, UNKP-22-3-1-SE-19]; National Research, Development and Innovation Office-NKFIH [K120706] Funding text: Funding/Support and role of the sponsor: Tibor Szarvas was supported by a Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences (BO/00451/20/5) . This work was supported by the UNKP-21-5-SE-3, UNKP-21-3-II-SE-13, UNKP-22-3-1-SE-19 New National Excellence Program of the Ministry for Innovation and Technology from the source of the National Research, Development and Innovation Fund. Tamas Koi is grateful for the support of the National Research, Development and Innovation Office-NKFIH K120706. The sponsor played a role in the design and conduct of the study. 0 false 2026-04-10T07:31:49.406+0000 2024-11-28T06:08:28.057+0000 2023-09-25T06:21:15.084+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2025-11-04T18:23:03.954+0000 2024-11-28T06:08:28.264+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Fazekas, Tamás Poly (ADP-ribose) Polymerase Inhibitors Have Comparable Efficacy with Platinum Chemotherapy in Patients with BRCA-positive Metastatic Castration-resistant Prostate Cancer. A Systematic Review and Meta-analysis true true /api/journal/20066258 REVIEWED true false false 20066258 true 2588-9311 2588-9311 Journal FOREIGN 7 3 365 375 365 11 2024 Testing for mutations in Breast Cancer Gene 1/2 (BRCA) has emerged as a novel decision-making tool for clinicians. Patients with metastatic castration-resistant prostate cancer (mCRPC) harboring pathogenic BRCA mutations can benefit from poly (ADP-ribose) polymerase inhibitor (PARPi) and platinum treatments, whereas the impact of the mutation on sensitivity to cabazitaxel and prostate-specific membrane antigen (PSMA)-ligand therapy is currently unknown.To assess the efficacy of PARPi, platinum, cabazitaxel, and PSMA-ligand therapies in BRCA-positive mCRPC.Databases were queried in February 2022. We performed data synthesis by using both proportional and individual patient data. For prostate-specific antigen (PSA) response rate (≥50% decrease from baseline [PSA50]) evaluation, we pooled event rates with 95% confidence intervals (CIs). Progression-free (PFS) and overall (OS) survival analyses with individual patient data were performed with the mixed-effect Cox proportional hazard model and single-arm random-effect analysis, providing pooled medians.We included 23 eligible studies with 901 BRCA-positive mCRPC patients. PSA50 response rates for PARPi and platinum were 69% (CI: 53-82%), and 74% (CI: 49-90%), respectively. Analyses of OS data showed no difference between PARPi and platinum treatments (hazard ratio: 0.86; CI: 0.49-1.52; p = 0.6). The single-arm OS and PFS analyses revealed similarities among different PARPis; pooled PFS and OS medians were 9.7 mo (CI: 8.1-12.5) and 17.4 mo (CI: 12.7-20.1), respectively.Our data revealed that different PARPis were similarly effective in terms of PFS and OS. Moreover, we found that PARPi and platinum therapy were comparable in terms of PSA50 response rate and OS, highlighting that platinum is a valid treatment option for BRCA-positive mCRPC patients. However, prospective interventional studies comparing these agents are essential to provide a higher level of evidence.In this report, we found that different poly (ADP-ribose) polymerase inhibitors had similar efficacy, and platinum was a valid treatment option in BRCA-positive metastatic castration-resistant prostate cancer patients. 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(SE / AOK / K / SZSZNK); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE); Urológiai Klinika (SE / AOK / K) 10 52 6 11 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 109993754 /api/authorship/109993754 1 0.091 true false false Author 10073300 /api/author/10073300 Fazekas Tamás true true Fazekas Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993755 /api/authorship/109993755 2 0.091 false false false Author 10085941 /api/author/10085941 Széles Ádám Dániel true true Széles Ádám D true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993756 /api/authorship/109993756 3 0.091 false false false Author 10078049 /api/author/10078049 Teutsch Brigitta true true Teutsch Brigitta true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993757 /api/authorship/109993757 4 0.091 false false false Author 10064212 /api/author/10064212 Pásztor-Csizmarik Anita true 10064212 true Csizmarik Anita true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993758 /api/authorship/109993758 5 0.091 false false false Author 10084110 /api/author/10084110 Vékony Bálint true true Vékony Bálint true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993759 /api/authorship/109993759 6 0.091 false false false Author 10042217 /api/author/10042217 Kói Tamás true 10042217 true Kói Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993760 /api/authorship/109993760 7 0.091 false false false Author 10013998 /api/author/10013998 Ács Nándor true 10013998 true Ács Nándor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993761 /api/authorship/109993761 8 0.091 false false false Author 10002629 /api/author/10002629 Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993762 /api/authorship/109993762 9 0.09090909 false false false Hadaschik Boris true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993763 /api/authorship/109993763 10 0.091 false false false Author 10013343 /api/author/10013343 Nyirády Péter true 10013343 true Nyirády Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109993764 /api/authorship/109993764 11 0.091 false true true Author 10052466 /api/author/10052466 Szarvas Tibor true 10052466 true Szarvas Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24407253 /api/publicationidentifier/24407253 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1016/j.euo.2023.09.001 https://doi.org/10.1016/j.euo.2023.09.001 false true PublicationIdentifier 26717197 /api/publicationidentifier/26717197 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001243624000001 https://www.webofscience.com/wos/woscc/full-record/001243624000001 false true PublicationIdentifier 26243576 /api/publicationidentifier/26243576 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85193647225 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85193647225 false true PublicationIdentifier 24407252 /api/publicationidentifier/24407252 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37722977 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37722977&dopt=Abstract false true Keyword 3375201 /api/keyword/3375201 true true SjrRating 11504406 /api/sjrrating/11504406 2 0.0 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2746 /api/classificationexternal/2746 true 2746 true D1 DIRECT true true /api/publication/34153931 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10073300"><a href="/gui2/?type=authors&mode=browse&sel=10073300" target="_blank">Fazekas Tamás (<span class="authorship-author-name">Fazekas Tamás</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10085941"><a href="/gui2/?type=authors&mode=browse&sel=10085941" target="_blank">Széles Ádám D (<span class="authorship-author-name">Széles Ádám Dániel</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078049"><a href="/gui2/?type=authors&mode=browse&sel=10078049" target="_blank">Teutsch Brigitta (<span class="authorship-author-name">Teutsch Brigitta</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064212"><a href="/gui2/?type=authors&mode=browse&sel=10064212" target="_blank">Csizmarik Anita (<span class="authorship-author-name">Pásztor-Csizmarik Anita</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084110"><a href="/gui2/?type=authors&mode=browse&sel=10084110" target="_blank">Vékony Bálint (<span class="authorship-author-name">Vékony Bálint</span> <span class="authorAux-mtmt"> endokrinológia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10042217"><a href="/gui2/?type=authors&mode=browse&sel=10042217" target="_blank">Kói Tamás (<span class="authorship-author-name">Kói Tamás</span> <span class="authorAux-mtmt"> információelmélet</span>) </a> </span> <span class="author-affil"><span title="Budapest University of Technology and Economics">BUTE</span>/<span title="Faculty of Natural Sciences">FNS</span>/<span title="Institute of Mathematics">IM</span>/Department of Stochastics; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013998"><a href="/gui2/?type=authors&mode=browse&sel=10013998" target="_blank">Ács Nándor (<span class="authorship-author-name">Ács Nándor</span> <span class="authorAux-mtmt"> Szülészet-nőgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/<span title="Department of Obsterics and Gynecology">DOG</span>/Department of Obsterics and Gynecology Üllői Street Department</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002629"><a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (<span class="authorship-author-name">Hegyi Péter</span> <span class="authorAux-mtmt"> Gasztroenterológia</span>) </a> </span> <span class="author-affil"><span title="University of Pécs">UP</span>/<span title="Medical School">UPMS</span>/Institute for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Institute of Pancreatic Diseases</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Hadaschik Boris </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013343"><a href="/gui2/?type=authors&mode=browse&sel=10013343" target="_blank">Nyirády Péter (<span class="authorship-author-name">Nyirády Péter</span> <span class="authorAux-mtmt"> Urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology; <span title="Semmelweis University">SU</span>/<span title="Központi Szervezeti Egységek (beleértve az Egyéb Szervezeti Egységeket)">KSZE</span>/Centre for Translational Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052466"><a href="/gui2/?type=authors&mode=browse&sel=10052466" target="_blank">Szarvas Tibor ✉ (<span class="authorship-author-name">Szarvas Tibor</span> <span class="authorAux-mtmt"> urológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Department of Urology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34153931" target="_blank">Poly (ADP-ribose) Polymerase Inhibitors Have Comparable Efficacy with Platinum Chemotherapy in Patients with BRCA-positive Metastatic Castration-resistant Prostate Cancer. A Systematic Review and Meta-analysis</a></div> <div> <span class="journal-title">European Urology Oncology</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2588-9311">2588-9311</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2588-9311">2588-9311</a>)</span>: <span class="journal-volume">7</span> <span class="journal-issue">3</span> <span class="page"> pp 365-375 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1016/j.euo.2023.09.001" target="_blank" href="https://doi.org/10.1016/j.euo.2023.09.001"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001243624000001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001243624000001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85193647225" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85193647225"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37722977" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37722977&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Oncology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Radiology, Nuclear Medicine and Imaging&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Surgery&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Urology&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 11</span> | Independent citation: 7 | Self citation: 4 | Unknown citation: 0 | Number of citations in WoS: 10 | Number of citations in Scopus:&nbsp;10 | WoS/Scopus assigned:&nbsp;11 | Number of citations with DOI:&nbsp;11 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34153931&sort=publishedYear,desc&sort=title"> Number of cited publications: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34153931</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Survey paper ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (ÚNKP-21-5-SE-3), (BO/00451/20/5), (ÚNKP-21-3-II-SE-13), (ÚNKP-22-3-1-SE-19), (K120706) </div> <div class="lastModified">Last Modified: 2024.11.28. 07:08 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Janos Bolyai Research Scholarship of the Hungarian Academy of Sciences [BO/00451/20/5]; New National Excellence Program of the Ministry for Innovation and Technology [UNKP-21-5-SE-3, UNKP-21-3-II-SE-13, UNKP-22-3-1-SE-19]; National Research, Development and Innovation Office-NKFIH [K120706] Funding text: Funding/Support and role of the sponsor: Tibor...</pre> </div></div>