The Clinical Validation of Modulated Electro-Hyperthermia (mEHT)

Lee, Sun-Young; Lorant, Gergo [Lóránt, Gergő (Általános orvos), author] Department of Internal Medicine and Oncology (SU / FM / C); Grand, Laszlo [Grand, László (Idegtudomány), author] Információs Technológiai és Bionikai Kar (PPCU); Szasz, Attila Marcell ✉ [Szász, Attila Marcell (emlőpatologia), author] Department of Internal Medicine and Oncology (SU / FM / C)

English Survey paper (Journal Article) Scientific
Published: CANCERS 2072-6694 15 (18) Paper: 4569 , 27 p. 2023
  • SJR Scopus - Oncology: Q1
Identifiers
Fundings:
  • NKFIH(NVKP_16-1-2016-0042)
  • (KDP-2020) Funder: Ministry for Innovation and Technology
Subjects:
  • Clinical medicine
  • Anticancer therapy
The mEHT method uses tissues’ thermal and bioelectromagnetic heterogeneity for the selective mechanisms. The success of the therapy for advanced, relapsed, and metastatic aggressive tumors can only be demonstrated by measuring survival time and quality of life (QoL). The complication is that mEHT-treated patients cannot be curatively treated any longer with “gold standards”, where the permanent progression of the disease, the refractory, relapsing situation, the organ failure, the worsening of blood counts, etc., block them. Collecting a cohort of these patients is frequently impossible. Only an intent-to-treat (ITT) patient group was available. Due to the above limitations, many studies have single-arm data collection. The Phase III trial of advanced cervix tumors subgrouping of HIV-negative and -positive patients showed the stable efficacy of mEHT in all patients’ subgroups. The single-arm represents lower-level evidence, which can be improved by comparing the survival data of various studies from different institutes. The Kaplan–Meier probability comparison had no significant differences, so pooled data were compared to other methods. Following this approach, we demonstrate the feasibility and superiority of mEHT in the cases of glioblastoma multiform, pancreas carcinomas, lung tumors, and colorectal tumors.
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2025-04-01 23:25