https://m2.mtmt.hu/ hun 2026-09-22 13:38 JournalArticle 34144416 VALIDATED true 0 false 2026-09-22T07:06:11.336+0000 2024-01-05T07:23:40.555+0000 2023-09-18T11:40:37.985+0000 true 10050782 Somogyvári Milán /api/author/10050782 Author Somogyvári Milán (Molekuláris biológia) true 10050782 2024-10-24T13:26:30.457+0000 2023-09-25T10:59:09.335+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Hajdú, Gábor true true /api/journal/10086915 REVIEWED COMMUNICATIONS BIOLOGY 2399-3642 true false 10086915 false 10086915 true 2399-3642 Journal FOREIGN 6 1 936 936 17 2023 Lysosome-related organelles (LROs) play diverse roles and their dysfunction causes immunodeficiency. However, their primordial functions remain unclear. Here, we report that C. elegans LROs (gut granules) promote organismal defenses against various stresses. We find that toxic benzaldehyde exposure induces LRO autofluorescence, stimulates the expression of LRO-specific genes and enhances LRO transport capacity as well as increases tolerance to benzaldehyde, heat and oxidative stresses, while these responses are impaired in glo-1 /Rab32 and pgp- 2 ABC transporter LRO biogenesis mutants. Benzaldehyde upregulates glo-1 - and pgp-2- dependent expression of heat shock, detoxification and antimicrobial effector genes, which requires daf-16 /FOXO and/or pmk-1 /p38MAPK. Finally, benzaldehyde preconditioning increases resistance against Pseudomonas aeruginosa PA14 in a glo-1 - and pgp-2 -dependent manner, and PA14 infection leads to the deposition of fluorescent metabolites in LROs and induction of LRO genes. Our study suggests that LROs may play a role in systemic responses to stresses and in pathogen resistance. Funding 2031346 /api/funding/2031346 (OTKA K116525) Támogató: NKFI false true Funding 2031347 /api/funding/2031347 (PD142838) false true Funding 2031348 /api/funding/2031348 (K131458) false true Funding 2031349 /api/funding/2031349 (STIA_18_M/6800313263) false true Funding 2031350 /api/funding/2031350 (STIA-KFI-2020/132257/AOMBT/2020) false true Funding 2031351 /api/funding/2031351 (2020-4.1.1.-TKP2020) false true Funding 2031352 /api/funding/2031352 (TKP2021-EGA-24) false true Funding 2031353 /api/funding/2031353 (Molecular Biology Thematic Programme of Semmelweis University) false true Funding 2031354 /api/funding/2031354 (Open access funding provided by Semmelweis University) false true true 2023 true true true false false GOLD 2026-09-22 false https://www.nature.com/commsbio/ 17 0 17 16 1 17 17 16 15 17 17 16 16 16 1 0 17 16 17 16 0 3 3 Folyóiratcikk Journal Article 24 17 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 8 7 8 7 2025 0 6 6 6 6 2026 0 3 3 3 3 D1 false 10050782,10012506 false false false 2023-09-24T10:59:09.013+0000 Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 4 9 1 4 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 109934804 /api/authorship/109934804 Hajdú, Gábor [Hajdú, Gábor (Molekuláris biológia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 1 0.25 true false false Author 10063746 /api/author/10063746 Hajdú Gábor (Molekuláris biológia) Hajdú Gábor true 10063746 true Hajdú Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109934805 /api/authorship/109934805 Somogyvári, Milán [Somogyvári, Milán (Molekuláris biológia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 2 0.25 false false false Author 10050782 /api/author/10050782 Somogyvári Milán (Molekuláris biológia) Somogyvári Milán true 10050782 true Somogyvári Milán true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109934806 /api/authorship/109934806 Csermely, Péter [Csermely, Péter (Biokémia), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 3 0.25 false false false Author 1035707 /api/author/1035707 Csermely Péter (Biokémia) Csermely Péter true 1035707 true Csermely Péter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109934807 /api/authorship/109934807 Sőti, Csaba ✉ [Sőti, Csaba (Biokémia, molekul...), szerző] Molekuláris Biológiai Tanszék (SE / AOK / I / BMBI) 4 0.25 false true true Author 10012506 /api/author/10012506 Sőti Csaba (Biokémia, molekuláris biológia) Sőti Csaba true 10012506 true Sőti Csaba true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24382910 /api/publicationidentifier/24382910 DOI: 10.1038/s42003-023-05246-7 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.1038/s42003-023-05246-7 https://doi.org/10.1038/s42003-023-05246-7 false true PublicationIdentifier 25224737 /api/publicationidentifier/25224737 WoS: 001115920200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS 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(2023) COMMUNICATIONS BIOLOGY 2399-3642 6 1<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10063746"><a href="/gui2/?type=authors&mode=browse&sel=10063746" target="_blank">Hajdú Gábor (<span class="authorship-author-name">Hajdú Gábor</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10050782"><a href="/gui2/?type=authors&mode=browse&sel=10050782" target="_blank">Somogyvári Milán (<span class="authorship-author-name">Somogyvári Milán</span> <span class="authorAux-mtmt"> Molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="1035707"><a href="/gui2/?type=authors&mode=browse&sel=1035707" target="_blank">Csermely Péter (<span class="authorship-author-name">Csermely Péter</span> <span class="authorAux-mtmt"> Biokémia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012506"><a href="/gui2/?type=authors&mode=browse&sel=10012506" target="_blank">Sőti Csaba ✉ (<span class="authorship-author-name">Sőti Csaba</span> <span class="authorAux-mtmt"> Biokémia, molekuláris biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Biokémiai és Molekuláris Biológiai Intézet">BMBI</span>/Molekuláris Biológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34144416" target="_blank">Lysosome-related organelles promote stress and immune responses in C. elegans</a></div> <div> <span class="journal-title">COMMUNICATIONS BIOLOGY</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2399-3642">2399-3642</a>)</span>: <span class="journal-volume">6</span> <span class="journal-issue">1</span> <span class="page"> Paper 936. 17 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1038/s42003-023-05246-7" target="_blank" href="https://doi.org/10.1038/s42003-023-05246-7"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001115920200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001115920200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85171157326" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85171157326"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37704756" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37704756&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Agricultural and Biological Sciences (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Biochemistry, Genetics and Molecular Biology (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 17</span> | Független: 16 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 16 | Scopus jelölt:&nbsp;15 | WoS/Scopus jelölt:&nbsp;17 | DOI jelölt:&nbsp;17 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34144416&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 3 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34144416</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (OTKA K116525) Támogató: NKFI, (PD142838), (K131458), (STIA_18_M/6800313263), (STIA-KFI-2020/132257/AOMBT/2020), Tématerületi Kiválósági Program(2020-4.1.1.-TKP2020), (TKP2021-EGA-24), (Molecular Biology Thematic Programme of Semmelweis University), (Open access funding provided by Semmelweis University) </div> <div class="lastModified">Utolsó módosítás: 2024.01.05. 08:23 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>