A magyar gazdaság versenyképességének növelése a lakosság egészségi állapotát javító
népegészségü...(GINOP-2.3.2-15-2016-00005) Funder: GINOP
(TK2016-78)
(135784) Funder: NRDIO
Egészségbiztonság Nemzeti Laboratórium(RRF-2.3.1-21-2022-00006) Funder: NRDIO
Type 2 diabetes mellitus (T2DM) is a major global public health problem, as it is
associated with increased morbidity, mortality, and healthcare costs. Insulin resistance
(IR) is a condition characterized by disturbances in carbohydrate and lipid metabolism
that precedes T2DM. The aim of the present study was to investigate the association
between HDL and its subfraction profile and the progression of IR, as assessed by
the Homeostatic Model Assessment for IR (HOMA-IR) index, and to define cut-off values
to identify an increased risk of IR. Individuals with a HOMA-IR greater than 3.63
were considered to have IR. The HDL subfractions were separated using the Lipoprint
system, which identifies ten subfractions (HDL-1-10) in three subclasses as large
(HDL-L), intermediate (HDL-I) and small (HDL-S). Analyses were performed on samples
from 240 individuals without IR and 137 with IR from the Hungarian general and Roma
populations. The HDL-1 to -6 subfractions and the HDL-L and -I classes showed a significant
negative association with the progression and existence of IR. Among them, HDL-2 (B
= −40.37, p = 2.08 × 10−11) and HDL-L (B = −14.85, p = 9.52 × 10−10) showed the strongest
correlation. The optimal threshold was found to be 0.264 mmol/L for HDL-L and 0.102
mmol/L and above for HDL-2. Individuals with HDL-L levels below the reference value
had a 5.1-fold higher risk of IR (p = 2.2 × 10−7), while those with HDL-2 levels had
a 4.2-fold higher risk (p = 3.0 × 10−6). This study demonstrates that the HDL subfraction
profile (especially the decrease in HDL-2 and -L) may be a useful marker for the early
detection and intervention of atherogenic dyslipidemia in subjects with impaired glucose
and insulin metabolism.