https://m2.mtmt.hu/ hun 2026-05-25 23:51 JournalArticle 34136194 VALIDATED true Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1085, Hungary HCEMM-SU Cardiometabolic Immunology Research Group, Budapest, 1085, Hungary MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group, Semmelweis University, Budapest, 1085, Hungary 1st Department of Pathology and Experimental Cancer Research, Semmelweis University, Budapest, 1085, Hungary Heart and Vascular Center, Semmelweis University, Budapest, 1085, Hungary Institute of Pharmacology and Toxicology, University Medical Center Goettingen (UMG), Göttingen, 37075, Germany German Center for Cardiovascular Research (DZHK) Partner Site, Goettingen, 37075, Germany Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, National Institute of Health, Rockville, 20852, MD, United States MTA-SE System Pharmacology Research Group, Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1085, Hungary Pharmahungary Group, Szeged, 6720, Hungary Export Date: 21 May 2025; Cited By: 8; Correspondence Address: Z.V. Varga; Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1085, Hungary; email: varga.zoltan@med.semmelweis-univ.hu 0 false 2026-05-23T05:19:29.294+0000 2025-05-15T08:23:37.235+0000 2023-09-12T08:52:17.228+0000 true 10015403 Hizoh István /api/author/10015403 Author true 10015403 2026-03-27T10:20:37.912+0000 2026-03-27T10:20:37.912+0000 2025-05-15T08:23:37.672+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Sayour, Nabil V. Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction true true /api/journal/10003252 REVIEWED true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 18 13826 13826 18 2023 The identification of novel drug targets is needed to improve the outcomes of heart failure (HF). G-protein-coupled receptors (GPCRs) represent the largest family of targets for already approved drugs, thus providing an opportunity for drug repurposing. Here, we aimed (i) to investigate the differential expressions of 288 cardiac GPCRs via droplet digital PCR (ddPCR) and bulk RNA sequencing (RNAseq) in a rat model of left ventricular pressure-overload; (ii) to compare RNAseq findings with those of ddPCR; and (iii) to screen and test for novel, translatable GPCR drug targets in HF. Male Wistar rats subjected to transverse aortic constriction (TAC, n = 5) showed significant systolic dysfunction vs. sham operated animals (SHAM, n = 5) via echocardiography. In TAC vs. SHAM hearts, RNAseq identified 69, and ddPCR identified 27 significantly differentially expressed GPCR mRNAs, 8 of which were identified using both methods, thus showing a correlation between the two methods. Of these, Prostaglandin-F2α-receptor (Ptgfr) was further investigated and localized on cardiomyocytes and fibroblasts in murine hearts via RNA-Scope. Antagonizing Ptgfr via AL-8810 reverted angiotensin-II-induced cardiomyocyte hypertrophy in vitro. In conclusion, using ddPCR as a novel screening method, we were able to identify GPCR targets in HF. We also show that the antagonism of Ptgfr could be a novel target in HF by alleviating cardiomyocyte hypertrophy. Funding 2031294 /api/funding/2031294 false true Funding 2031295 /api/funding/2031295 false true Funding 2031296 /api/funding/2031296 false true Funding 2031297 /api/funding/2031297 false true Funding 2031298 /api/funding/2031298 false true Funding 2031299 /api/funding/2031299 false true Funding 2031300 /api/funding/2031300 false true Funding 2031301 /api/funding/2031301 false true Funding 2031302 /api/funding/2031302 false true Funding 2031303 /api/funding/2031303 false true Funding 2031304 /api/funding/2031304 false true Funding 2031305 /api/funding/2031305 false true true true 2023 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/ijms241813826 10 0 10 4 6 10 10 10 10 10 10 4 4 4 6 0 10 4 10 4 0 13 13 Folyóiratcikk Journal Article 24 10 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 3 1 3 1 2025 0 6 2 6 2 2026 0 1 1 1 1 D1 false 10040905,10081163 false false false 2023-09-24T06:48:03.832+0000 Farmakológiai és Farmakoterápiás Intézet (SE / AOK / I); HCEMM-SE Kardiometabolikus Immunológia Kutatócs... (SE / AOK / I / FFI); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); MTA-SE Momentum Kardio-Onkológia és Kardioimmun... (SE / AOK / I / FFI); MTA-SE Rendszerfarmakológiai Kutatócsoport (SE / AOK / I / FFI); Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 16 33 6 18 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 109851312 /api/authorship/109851312 1 0.056 true false false Author 10074459 /api/author/10074459 Sayour Viktor Nabil true true Sayour Nabil V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851313 /api/authorship/109851313 2 0.056 true false false Author 10040905 /api/author/10040905 Tóth Viktória true 10040905 true Tóth Viktória É. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851314 /api/authorship/109851314 3 0.055555556 false false false Author 10081163 /api/author/10081163 Nagy Regina Norma true true Nagy Regina N. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851315 /api/authorship/109851315 4 0.056 false false false Author 10065328 /api/author/10065328 Vörös Imre true 10065328 true Vörös Imre true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851316 /api/authorship/109851316 5 0.056 false false false Author 10074629 /api/author/10074629 Gergely Tamás G true true Gergely Tamás G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851317 /api/authorship/109851317 6 0.056 false false false Author 10061054 /api/author/10061054 Onódi Zsófia true 10061054 true Onódi Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851318 /api/authorship/109851318 7 0.056 false false false Author 10032345 /api/author/10032345 Nagy Noémi true 10032345 true Nagy Noémi true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851319 /api/authorship/109851319 8 0.056 false false false Author 10025100 /api/author/10025100 Bödör Csaba true 10025100 true Bödör Csaba true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851320 /api/authorship/109851320 9 0.056 false false false Author 10076998 /api/author/10076998 Váradi Barnabás true true Váradi Barnabás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851321 /api/authorship/109851321 10 0.056 false false false Author 10060212 /api/author/10060212 Ruppert Mihály true 10060212 true Ruppert Mihály true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851322 /api/authorship/109851322 11 0.056 false false false Author 10013969 /api/author/10013969 Radovits Tamás true 10013969 true Radovits Tamás true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851323 /api/authorship/109851323 12 0.055555556 false false false Bleckwedel Federico true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851324 /api/authorship/109851324 13 0.055555556 false false false Zelarayán Laura C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851325 /api/authorship/109851325 14 0.056 false false false Author 10035169 /api/author/10035169 Pacher Pál true 10035169 true Pacher Pál true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851326 /api/authorship/109851326 15 0.056 false false false Author 10057401 /api/author/10057401 Ágg Bence true 10057401 true Ágg Bence true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851327 /api/authorship/109851327 16 0.056 false false false Author 10027602 /api/author/10027602 Görbe Anikó true 10027602 true Görbe Anikó true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851328 /api/authorship/109851328 17 0.056 false false false Author 10010125 /api/author/10010125 Ferdinandy Péter true 10010125 true Ferdinandy Péter true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109851329 /api/authorship/109851329 18 0.056 false true true Author 10028393 /api/author/10028393 Varga Zoltán true 10028393 true Varga Zoltán V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24363417 /api/publicationidentifier/24363417 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms241813826 https://doi.org/10.3390/ijms241813826 false true PublicationIdentifier 24547201 /api/publicationidentifier/24547201 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001077128100001 https://www.webofscience.com/wos/woscc/full-record/001077128100001 true true PublicationIdentifier 24501135 /api/publicationidentifier/24501135 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85173005409 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85173005409 false true PublicationIdentifier 24522406 /api/publicationidentifier/24522406 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37762130 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37762130&dopt=Abstract true true SjrRating 11388415 /api/sjrrating/11388415 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 true 1604 true D1 DIRECT true true Reference 44973345 /api/reference/44973345 1 10.1001/jama.2020.10262 false true Reference 44973346 /api/reference/44973346 2 10.1016/j.jacc.2017.08.074 false true Reference 44973347 /api/reference/44973347 3 10.1161/JAHA.119.013441 false true Reference 44973348 /api/reference/44973348 4 10.1093/cvr/cvac013 false true Reference 44973349 /api/reference/44973349 5 false true Reference 44973350 /api/reference/44973350 6 10.1038/d41573-019-00074-z false true Reference 44973351 /api/reference/44973351 7 10.7150/ijbs.24612 false true Reference 44973352 /api/reference/44973352 8 10.1038/nrd.2017.178 false true Reference 44973353 /api/reference/44973353 9 10.1093/eurheartj/ehab368 false true Reference 44973354 /api/reference/44973354 10 10.1161/CIRCRESAHA.118.311403 false true Reference 44973355 /api/reference/44973355 11 10.1371/journal.pone.0235563 false true Reference 44973356 /api/reference/44973356 12 10.13070/mm.en.3.203 false true Reference 44973357 /api/reference/44973357 13 10.1038/s41598-017-02217-x false true Reference 44973358 /api/reference/44973358 14 false true Reference 44973359 /api/reference/44973359 15 10.1016/j.echo.2020.05.017 false true Reference 44973360 /api/reference/44973360 16 10.1161/CIRCRESAHA.117.312624 false true Reference 44973361 /api/reference/44973361 17 10.1371/journal.pone.0045489 false true Reference 44973362 /api/reference/44973362 18 10.1073/pnas.0811834106 false true Reference 44973363 /api/reference/44973363 19 10.1161/CIRCRESAHA.108.179770 false true Reference 44973364 /api/reference/44973364 20 10.1038/nm.2066 false true Reference 44973365 /api/reference/44973365 21 10.1016/j.biocel.2012.03.013 false true Reference 44973366 /api/reference/44973366 22 10.1016/j.ejphar.2022.174892 false true Reference 44973367 /api/reference/44973367 23 10.1038/s41586-018-0590-4 false true Reference 44973368 /api/reference/44973368 24 10.1038/s42003-022-04402-9 false true Reference 44973369 /api/reference/44973369 25 false true Reference 44973370 /api/reference/44973370 26 10.1074/jbc.M109.077164 false true Reference 44973371 /api/reference/44973371 27 10.1210/me.2011-1245 false true Reference 44973372 /api/reference/44973372 28 10.1152/ajpcell.00416.2004 false true Reference 44973373 /api/reference/44973373 29 10.3390/ijms221910504 false true Reference 44973374 /api/reference/44973374 30 10.3390/ph15091055 false true Reference 44973375 /api/reference/44973375 31 10.3390/cells9030551 false true Reference 44973376 /api/reference/44973376 32 10.1093/cvr/cvad024 false true Reference 44973377 /api/reference/44973377 33 10.3791/61901 false true Reference 44973378 /api/reference/44973378 34 10.1038/s41586-022-04817-8 false true Reference 44973379 /api/reference/44973379 35 10.3389/fphar.2010.00116 false true Reference 44973380 /api/reference/44973380 36 10.3390/ijms24044193 false true Reference 44973381 /api/reference/44973381 37 false true Reference 44973382 /api/reference/44973382 38 10.1093/molehr/8.7.681 false true Reference 44973383 /api/reference/44973383 39 10.1016/j.cellsig.2008.07.013 false true Reference 44973384 /api/reference/44973384 40 10.1152/ajpheart.1996.271.6.H2197 false true Reference 44973385 /api/reference/44973385 41 10.1161/01.CIR.97.16.1536 false true Reference 44973386 /api/reference/44973386 42 10.1074/jbc.271.16.9863 false true Reference 44973387 /api/reference/44973387 43 false true Reference 44973388 /api/reference/44973388 44 10.1016/j.ejphar.2016.04.037 false true Reference 44973389 /api/reference/44973389 45 10.1016/j.yjmcc.2015.02.019 false true Reference 44973390 /api/reference/44973390 46 10.1038/s41598-018-25489-3 false true Reference 44973391 /api/reference/44973391 47 10.1093/cvr/cvx061 false true Reference 44973392 /api/reference/44973392 48 10.1016/j.peptides.2013.05.006 false true Reference 44973393 /api/reference/44973393 49 10.1161/JAHA.113.000249 false true Reference 44973394 /api/reference/44973394 50 10.3389/fphar.2020.611561 false true Reference 44973395 /api/reference/44973395 51 10.1016/j.jaci.2011.11.052 false true Reference 44973396 /api/reference/44973396 52 10.1007/s12031-017-1025-7 false true Reference 44973397 /api/reference/44973397 53 10.3390/ijms23073715 false true Reference 44973398 /api/reference/44973398 54 10.1016/j.jchf.2017.02.021 false true Reference 44973399 /api/reference/44973399 55 10.1016/j.jacbts.2018.11.001 false true Reference 44973400 /api/reference/44973400 56 10.1186/s12872-021-02146-8 false true Reference 44973401 /api/reference/44973401 57 10.14806/ej.17.1.200 false true Reference 44973402 /api/reference/44973402 58 10.1186/s12859-016-0956-2 false true Reference 44973403 /api/reference/44973403 59 10.1093/bioinformatics/btw354 false true Reference 44973404 /api/reference/44973404 60 10.1038/nmeth.3317 false true Reference 44973405 /api/reference/44973405 61 10.1093/bioinformatics/btt656 false true Reference 44973406 /api/reference/44973406 62 10.1093/bioinformatics/btp352 false true Reference 44973407 /api/reference/44973407 63 10.1093/gigascience/giab008 false true Reference 44973408 /api/reference/44973408 64 10.1186/s13059-014-0550-8 false true Reference 44973409 /api/reference/44973409 65 false true Reference 44973410 /api/reference/44973410 66 10.1007/s00395-010-0097-0 false true Reference 44973411 /api/reference/44973411 67 10.1101/cshperspect.a003996 false true Reference 44973412 /api/reference/44973412 68 10.1177/002215540405200109 false true Reference 44973413 /api/reference/44973413 69 false true Reference 44973414 /api/reference/44973414 70 10.1186/s12917-018-1387-2 false true Reference 44973415 /api/reference/44973415 71 10.1042/bj2440705 false true Reference 44973416 /api/reference/44973416 72 10.1007/BF02982713 false true /api/publication/34136194 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10074459"><a href="/gui2/?type=authors&mode=browse&sel=10074459" target="_blank">Sayour Nabil V. (<span class="authorship-author-name">Sayour Viktor Nabil</span> <span class="authorAux-mtmt"> farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040905"><a href="/gui2/?type=authors&mode=browse&sel=10040905" target="_blank">Tóth Viktória É.<sup>*</sup> (<span class="authorship-author-name">Tóth Viktória</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081163"><a href="/gui2/?type=authors&mode=browse&sel=10081163" target="_blank">Nagy Regina N. (<span class="authorship-author-name">Nagy Regina Norma</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10065328"><a href="/gui2/?type=authors&mode=browse&sel=10065328" target="_blank">Vörös Imre (<span class="authorship-author-name">Vörös Imre</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074629"><a href="/gui2/?type=authors&mode=browse&sel=10074629" target="_blank">Gergely Tamás G. (<span class="authorship-author-name">Gergely Tamás G</span> <span class="authorAux-mtmt"> kardiovaszkuláris farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061054"><a href="/gui2/?type=authors&mode=browse&sel=10061054" target="_blank">Onódi Zsófia (<span class="authorship-author-name">Onódi Zsófia</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032345"><a href="/gui2/?type=authors&mode=browse&sel=10032345" target="_blank">Nagy Noémi (<span class="authorship-author-name">Nagy Noémi</span> <span class="authorAux-mtmt"> Tumorbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025100"><a href="/gui2/?type=authors&mode=browse&sel=10025100" target="_blank">Bödör Csaba (<span class="authorship-author-name">Bödör Csaba</span> <span class="authorAux-mtmt"> Molekuláris Onkohematológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076998"><a href="/gui2/?type=authors&mode=browse&sel=10076998" target="_blank">Váradi Barnabás (<span class="authorship-author-name">Váradi Barnabás</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060212"><a href="/gui2/?type=authors&mode=browse&sel=10060212" target="_blank">Ruppert Mihály (<span class="authorship-author-name">Ruppert Mihály</span> <span class="authorAux-mtmt"> orvostudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10013969"><a href="/gui2/?type=authors&mode=browse&sel=10013969" target="_blank">Radovits Tamás (<span class="authorship-author-name">Radovits Tamás</span> <span class="authorAux-mtmt"> kardiológia, érgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bleckwedel Federico </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Zelarayán Laura C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10035169"><a href="/gui2/?type=authors&mode=browse&sel=10035169" target="_blank">Pacher Pál (<span class="authorship-author-name">Pacher Pál</span> <span class="authorAux-mtmt"> Kardiovaszkuláris Farmakológia</span>) </a> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10057401"><a href="/gui2/?type=authors&mode=browse&sel=10057401" target="_blank">Ágg Bence (<span class="authorship-author-name">Ágg Bence</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Rendszerfarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027602"><a href="/gui2/?type=authors&mode=browse&sel=10027602" target="_blank">Görbe Anikó (<span class="authorship-author-name">Görbe Anikó</span> <span class="authorAux-mtmt"> orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010125"><a href="/gui2/?type=authors&mode=browse&sel=10010125" target="_blank">Ferdinandy Péter (<span class="authorship-author-name">Ferdinandy Péter</span> <span class="authorAux-mtmt"> Farmakológia, molekuláris medicina</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Rendszerfarmakológiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10028393"><a href="/gui2/?type=authors&mode=browse&sel=10028393" target="_blank">Varga Zoltán V. ✉ (<span class="authorship-author-name">Varga Zoltán</span> <span class="authorAux-mtmt"> kardiovaszkuláris kutatás</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Farmakológiai és Farmakoterápiás Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/HCEMM-SE Kardiometabolikus Immunológia Kutatócsoport; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/<span title="Farmakológiai és Farmakoterápiás Intézet">FFI</span>/MTA-SE Momentum Kardio-Onkológia és Kardioimmunológia Kutatócsoport</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34136194" target="_blank">Droplet Digital PCR Is a Novel Screening Method Identifying Potential Cardiac G-Protein-Coupled Receptors as Candidate Pharmacological Targets in a Rat Model of Pressure-Overload-Induced Cardiac Dysfunction</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">18</span> <span class="page"> Paper 13826. 18 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms241813826" target="_blank" href="https://doi.org/10.3390/ijms241813826"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001077128100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001077128100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85173005409" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85173005409"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37762130" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37762130&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 10</span> | Független: 4 | Függő: 6 | Nem jelölt: 0 | WoS jelölt: 10 | Scopus jelölt:&nbsp;10 | WoS/Scopus jelölt:&nbsp;10 | DOI jelölt:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34136194&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 13 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34136194</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> HCEMM(739593) Támogató: Horizon 2020, (LP-2021-14), (RRF-2.3.1-21-2022-00003), National Heart Program(NVKP-16-1-2016-0017) Támogató: NKFIH, Tématerületi Kiválósági Program(2020-4.1.1.-TKP2020), (TKP2021-EGA-23) Támogató: Innovációs és Technológiai Minisztérium, National Research, Development and Innovation Office (NKFIH) of Hungary(K134939), National Research, Development and Innovation Office (NKFIH) of Hungary(FK134751), János Bolyai Research Scholarship of the Hungarian Academy of Sciences, (ÚNKP-22-5-SE-20), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Támogató: EFOP-VEKOP, (European Union’s Horizon 2020 Research and Innovation (101007931)) </div> <div class="lastModified">Utolsó módosítás: 2025.05.15. 10:23 Gere Tamásné (SE_KK_Admin5_GT, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, 1085, Hungary HCEMM-SU Cardiometabolic Immunology Research Group, Budapest, 1085, Hungary MTA-SE Momentum Cardio-Oncology and Cardioimmunology Research Group, Semmelweis University, Budapest, 1085, Hungary 1st Department of Pathology and Experi...</pre> </div></div>