https://m2.mtmt.hu/ eng 2026-05-31 13:05 JournalArticle 34131836 VALIDATED true Funding Agency and Grant Number: The authors thank Dora Bokor, PharmD, for proofreading the manuscript. Funding text: The authors thank Dora Bokor, PharmD, for proofreading the manuscript. 0 false 2026-05-28T07:10:59.195+0000 2023-10-15T10:26:43.084+0000 2023-09-08T08:25:57.965+0000 true 10064491 Senobar Tahaei Seyyed Ashkan /api/author/10064491 Author Seyyed Ashkan Senobar Tahaei (Farmakológia) true 10064491 2024-06-13T14:33:12.120+0000 2024-06-13T14:33:12.120+0000 2023-09-28T06:48:11.371+0000 true 10083973 Szalai Fruzsina /api/admin/10083973 Admin Fruzsina Szalai (SZTE admin5) true Admin 10014568 /api/admin/10014568 Andrea Vándor (VA, admin) Vándor Andrea true 10014568 true 2024-04-03T13:49:18.664+0000 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Article (Journal Article) 101 true 10000059 true 1 /api/category/1 Category Scientific true 1 Senobar Tahaei, Seyyed Ashkan true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 18 13749 13749 16 2023 Four diastereomers of 16-azidomethyl substituted 3-O-benzyl estradiol (1–4) and their two estrone analogs (16AABE and 16BABE) were tested for their antiproliferative properties against human gynecological cancer cell lines. The estrones were selected for additional experiments based on their outstanding cell growth-inhibiting activities. Both compounds increased hypodiploid populations of breast cancer cells, and 16AABE elicited cell cycle disturbance as evidenced by flow cytometry. The two analogs substantially increased the rate of tubulin polymerization in vitro. 16AABE and 16BABE inhibited breast cancer cells’ migration and invasive ability, as evidenced by wound healing and Boyden chamber assays. Since both estrone analogs exerted remarkable estrogenic activities, as documented by a luciferase reporter gene assay, they can be considered as promising drug candidates for hormone-independent malignancies. true 2023 true true true false true false GOLD 2026-05-28 true https://doi.org/10.3390/ijms241813749 1 0 1 1 0 1 1 1 1 1 1 1 1 1 0 0 1 1 1 1 0 6 6 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 1 1 1 D1 false 10012035 false false false 2023-09-26T10:57:18.251+0000 Genetikai Intézet (HRN SZBK); Gyógyszerhatástani és Biofarmáciai Intézet (SZTE / GYTK); Központi Laboratóriumok (HRN SZBK); Molekuláris és Analitikai Kémiai Tanszék (SZTE / TTIK / KI); Orvosi Vegytani Intézet (SZTE / SZAOK); Szerves Kémiai Tanszék (SZTE / TTIK / KI); Természetes Vegyületek Interdiszciplináris Központ (SZTE / KE) 9 40 7 10 0 true 10014568 Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 109825597 /api/authorship/109825597 Senobar Tahaei, Seyyed Ashkan [Senobar Tahaei, Seyyed Ashkan (Farmakológia), author] Department of Pharmacodynamics and Biopharmacy (SZTE / FP) 1 0.1 true false false Author 10064491 /api/author/10064491 Seyyed Ashkan Senobar Tahaei (Farmakológia) Senobar Tahaei Seyyed Ashkan true 10064491 true Senobar Tahaei Seyyed Ashkan true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109825598 /api/authorship/109825598 Kulmány, Ágnes [Kulmány, Ágnes Erika (Farmakológia - On...), author] Department of Pharmacodynamics and Biopharmacy (SZTE / FP) 2 0.1 false false false Author 10060141 /api/author/10060141 Ágnes Erika Kulmány (Farmakológia - Onkofarmakológia) Kulmány Ágnes Erika true 10060141 true Kulmány Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109825599 /api/authorship/109825599 Minorics, Renáta [Minorics, Renáta (Farmakológia), author] Department of Pharmacodynamics and Biopharmacy (SZTE / FP) 3 0.1 false false false Author 10012034 /api/author/10012034 Renáta Minorics (Farmakológia) Minorics Renáta true 10012034 true Minorics Renáta true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109825600 /api/authorship/109825600 Kiss, Anita [Kiss, Anita (Szerves kémia), author] Department of Organic Chemistry (SZTE / TTIK / KI); Department of Molecular and Analytical Chemistry (SZTE / TTIK / KI) 4 0.1 false false false Author 10064024 /api/author/10064024 Anita Kiss (Szerves kémia) Kiss Anita true 10064024 true Kiss Anita true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109825601 /api/authorship/109825601 Szabó, Zoltán [Szabó, Zoltán (proteomika), author] Department of Medical Chemistry (SZTE / ASZMS) 5 0.1 false false false Author 10027486 /api/author/10027486 Zoltán Szabó (proteomika) Szabó Zoltán true 10027486 true Szabó Zoltán true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109825602 /api/authorship/109825602 Germán, Péter 6 0.1 false false false Germán Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109825603 /api/authorship/109825603 Szebeni, Gábor J. [Szebeni, Gábor (Immunológia), author] Institute of Genetics; Központi Laboratóriumok 7 0.1 false false false Author 10025339 /api/author/10025339 Gábor Szebeni (Immunológia) Szebeni Gábor true 10025339 true Szebeni Gábor J. true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109825604 /api/authorship/109825604 Gémes, Nikolett [Gémes, Nikolett (immunológia), author] Institute of Genetics; Központi Laboratóriumok 8 0.1 false false false Author 10081633 /api/author/10081633 Nikolett Gémes (immunológia) Gémes Nikolett true true Gémes Nikolett true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109825605 /api/authorship/109825605 Mernyák, Erzsébet ✉ [Mernyák, Erzsébet (Szerves kémia), author] Department of Organic Chemistry (SZTE / TTIK / KI); Department of Molecular and Analytical Chemistry (SZTE / TTIK / KI) 9 0.1 false false true Author 10012035 /api/author/10012035 Erzsébet Mernyák (Szerves kémia) Mernyák Erzsébet true 10012035 true Mernyák Erzsébet true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109825606 /api/authorship/109825606 Zupkó, István ✉ [Zupkó, István (Farmakológia), author] Department of Pharmacodynamics and Biopharmacy (SZTE / FP); Interdisciplinary Centre for Natural Products (SZTE / KE) 10 0.1 false true true Author 10001074 /api/author/10001074 István Zupkó (Farmakológia) Zupkó István true 10001074 true Zupkó István true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 24352880 /api/publicationidentifier/24352880 DOI: 10.3390/ijms241813749 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms241813749 https://doi.org/10.3390/ijms241813749 false true PublicationIdentifier 24417473 /api/publicationidentifier/24417473 REAL: 175107 SwordSource 36 /api/publicationsource/36 REAL PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GOLD true 175107 http://real.mtak.hu/175107 false true PublicationIdentifier 24489649 /api/publicationidentifier/24489649 WoS: 001073669400001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001073669400001 https://www.webofscience.com/wos/woscc/full-record/001073669400001 false true PublicationIdentifier 24516350 /api/publicationidentifier/24516350 Scopus: 85173007327 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85173007327 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85173007327 true true PublicationIdentifier 24428103 /api/publicationidentifier/24428103 PubMed: 37762056 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37762056 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37762056&dopt=Abstract true true PublicationIdentifier 24352881 /api/publicationidentifier/24352881 Other URL: https://www.mdpi.com/1422-0067/24/18/13749 PlainSource 40 /api/publicationsource/40 Other URL PublicationSourceType 10006 /api/publicationsourcetype/10006 Link true true true Egyéb URL Other URL @@@ true true 40 true https://www.mdpi.com/1422-0067/24/18/13749 https://www.mdpi.com/1422-0067/24/18/13749 false true PublicationIdentifier 24422612 /api/publicationidentifier/24422612 SZTE Publicatio: 28365 SwordSource 90 /api/publicationsource/90 SZTE Publicatio PublicationSourceType 10007 /api/publicationsourcetype/10007 Repozitórium true true true SZTE Publicatio SZTE Publicatio http://publicatio.bibl.u-szeged.hu/@@@ true true 90 true GREEN true IDENTICAL 28365 http://publicatio.bibl.u-szeged.hu/28365 false true Classification 12184 /api/classification/12184 Pharmacology and pharmacy true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 44902780 /api/reference/44902780 1. 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Wilson 2004: Development and characterization of a cell line that stably expresses an estrogen-responsive luciferase reporter for the detection of estrogen receptor agonist and antagonists., Toxicol. Sci., 81, p. 69, DOI: 10.1093/toxsci/kfh180 32 10.1093/toxsci/kfh180 false true /api/publication/34131836 Senobar Tahaei Seyyed Ashkan et al. Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs. (2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 18<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10064491"><a href="/gui2/?type=authors&mode=browse&sel=10064491" target="_blank">Senobar Tahaei Seyyed Ashkan (<span class="authorship-author-name">Senobar Tahaei Seyyed Ashkan</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics and Biopharmacy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060141"><a href="/gui2/?type=authors&mode=browse&sel=10060141" target="_blank">Kulmány Ágnes (<span class="authorship-author-name">Kulmány Ágnes Erika</span> <span class="authorAux-mtmt"> Farmakológia - Onkofarmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics and Biopharmacy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012034"><a href="/gui2/?type=authors&mode=browse&sel=10012034" target="_blank">Minorics Renáta (<span class="authorship-author-name">Minorics Renáta</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics and Biopharmacy</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10064024"><a href="/gui2/?type=authors&mode=browse&sel=10064024" target="_blank">Kiss Anita (<span class="authorship-author-name">Kiss Anita</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Organic Chemistry; <span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Molecular and Analytical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027486"><a href="/gui2/?type=authors&mode=browse&sel=10027486" target="_blank">Szabó Zoltán (<span class="authorship-author-name">Szabó Zoltán</span> <span class="authorAux-mtmt"> proteomika</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Albert Szent-Györgyi Medical School">ASZMS</span>/Department of Medical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Germán Péter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025339"><a href="/gui2/?type=authors&mode=browse&sel=10025339" target="_blank">Szebeni Gábor J. (<span class="authorship-author-name">Szebeni Gábor</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Genetics; <span title="Biological Research Centre, Szeged">BRC Szeged</span>/Központi Laboratóriumok</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10081633"><a href="/gui2/?type=authors&mode=browse&sel=10081633" target="_blank">Gémes Nikolett (<span class="authorship-author-name">Gémes Nikolett</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Biological Research Centre, Szeged">BRC Szeged</span>/Institute of Genetics; <span title="Biological Research Centre, Szeged">BRC Szeged</span>/Központi Laboratóriumok</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10012035"><a href="/gui2/?type=authors&mode=browse&sel=10012035" target="_blank">Mernyák Erzsébet ✉ (<span class="authorship-author-name">Mernyák Erzsébet</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Organic Chemistry; <span title="University of Szeged">SZTE</span>/<span title="Faculty of Science and Informatics">TTIK</span>/<span title="Kémiai Intézet">KI</span>/Department of Molecular and Analytical Chemistry</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10001074"><a href="/gui2/?type=authors&mode=browse&sel=10001074" target="_blank">Zupkó István ✉ (<span class="authorship-author-name">Zupkó István</span> <span class="authorAux-mtmt"> Farmakológia</span>) </a> </span> <span class="author-affil"><span title="University of Szeged">SZTE</span>/<span title="Faculty of Pharmacy">FP</span>/Department of Pharmacodynamics and Biopharmacy; <span title="University of Szeged">SZTE</span>/<span title="Központi egységek">KE</span>/Interdisciplinary Centre for Natural Products</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34131836" target="_blank">Antiproliferative and Antimetastatic Properties of 16-Azidomethyl Substituted 3-O-Benzyl Estrone Analogs</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">18</span> <span class="page"> Paper 13749. 16 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms241813749" target="_blank" href="https://doi.org/10.3390/ijms241813749"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:black" title="175107" target="_blank" href="http://real.mtak.hu/175107"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001073669400001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001073669400001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85173007327" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85173007327"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37762056" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37762056&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.mdpi.com/1422-0067/24/18/13749" target="_blank" href="https://www.mdpi.com/1422-0067/24/18/13749"> Other URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="28365" target="_blank" href="http://publicatio.bibl.u-szeged.hu/28365"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Catalysis&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> <div class="journal-subject">Journal subject: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 1 | Number of citations in Scopus:&nbsp;1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34131836&sort=publishedYear,desc&sort=title"> Number of cited publications: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34131836</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="lastModified">Last Modified: 2023.10.15. 12:26 István Zupkó (Farmakológia) </div> <div class="lockedBy">Centrally managed 2024.04.03. 15:49 Andrea Vándor (VA, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: The authors thank Dora Bokor, PharmD, for proofreading the manuscript. Funding text: The authors thank Dora Bokor, PharmD, for proofreading the manuscript.</pre> </div></div>