https://m2.mtmt.hu/ eng 2026-04-15 16:37 JournalArticle 34125713 APPROVED true Funding Agency and Grant Number: Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]; National Research, Development and Innovation Office [K131893] Funding text: This work was supported by Hungarian Brain Research Program Grant 2017-1.2.1-NKP-2017-00002 and National Research, Development and Innovation Office Grant K131893. We thank Peter Foldi, Eva Krizsan, Orsolya Papp, and Erzsebet Gregori for technical assistance and Laszlo Barna, the Nikon Microscopy Center at the Institute of Experimental Medicine, Nikon Austria, and Auro-Science Consulting for providing microscopy support. 0 false 2026-04-13T09:58:26.112+0000 2025-11-18T11:22:58.306+0000 2023-09-05T08:08:43.490+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2025-11-27T10:03:57.125+0000 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2024-04-17T14:19:25.471+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Nagy-Pál, Petra Structural organisation of perisomatic inhibition in the mouse medial prefrontal cortex true true /api/journal/2707 REVIEWED true false 2707 false 2707 true 0270-6474 1529-2401 Journal FOREIGN 43 42 6972 6987 6972 16 2023 Perisomatic inhibition profoundly controls neural function. However, the structural organization of inhibitory circuits giving rise to the perisomatic inhibition in the higher-order cortices is not completely known. Here, we performed a comprehensive analysis of those GABAergic cells in the medial prefrontal cortex (mPFC) that provide inputs onto the somata and proximal dendrites of pyramidal neurons. Our results show that most GABAergic axonal varicosities contacting the perisomatic region of superficial (layer 2/3) and deep (layer 5) pyramidal cells express parvalbumin (PV) or cannabinoid receptor type 1 (CB1). Further, we found that the ratio of PV/CB1 GABAergic inputs is larger on the somatic membrane surface of pyramidal tract neurons in comparison with those projecting to the contralateral hemisphere. Our morphologic analysis of<jats:italic>in vitro</jats:italic>labeled PV+ basket cells (PVBC) and CCK/CB1+ basket cells (CCKBC) revealed differences in many features. PVBC dendrites and axons arborized preferentially within the layer where their soma was located. In contrast, the axons of CCKBCs expanded throughout layers, although their dendrites were found preferentially either in superficial or deep layers. Finally, using anterograde trans-synaptic tracing we observed that PVBCs are preferentially innervated by thalamic and basal amygdala afferents in layers 5a and 5b, respectively. Thus, our results suggest that PVBCs can control the local circuit operation in a layer-specific manner via their characteristic arborization, whereas CCKBCs rather provide cross-layer inhibition in the mPFC.</jats:p><jats:p><jats:bold>SIGNIFICANCE STATEMENT</jats:bold>Inhibitory cells in cortical circuits are crucial for the precise control of local network activity. Nevertheless, in higher-order cortical areas that are involved in cognitive functions like decision-making, working memory, and cognitive flexibility, the structural organization of inhibitory cell circuits is not completely understood. In this study we show that perisomatic inhibitory control of excitatory cells in the medial prefrontal cortex is performed by two types of basket cells endowed with different morphologic properties that provide inhibitory inputs with distinct layer specificity on cells projecting to disparate areas. Revealing this difference in innervation strategy of the two basket cell types is a key step toward understanding how they fulfill their distinct roles in cortical network operations. 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Celluláris Idegélettani Kutatócsoport (HRN KOKI); Doktori Iskola (SE); Hálózat-Idegélettani Kutatócsoport (HRN KOKI); Kísérleti Orvostudományi Kutatóintézet 7 24 5 8 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 109781769 /api/authorship/109781769 1 0.125 true false Author 10065453 /api/author/10065453 Nagy-Pál Petra true true Nagy-Pál Petra true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781770 /api/authorship/109781770 2 0.125 false false Author 10018814 /api/author/10018814 Veres Judit true 10018814 true Veres Judit M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781771 /api/authorship/109781771 3 0.125 false false Author 10076935 /api/author/10076935 Fekete Zsuzsanna true true Fekete Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781772 /api/authorship/109781772 4 0.125 false false Author 10014208 /api/author/10014208 Karlócai Rita true 10014208 true Karlócai Mária R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781773 /api/authorship/109781773 5 0.125 false false Filippo Weisz true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781774 /api/authorship/109781774 6 0.125 false false Author 10060502 /api/author/10060502 Barabás Bence true 10060502 true Barabás Bence true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781775 /api/authorship/109781775 7 0.125 false false Author 10070310 /api/author/10070310 Reéb Zsófia true true Reéb Zsófia true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781776 /api/authorship/109781776 8 0.125 false true true Author 10010484 /api/author/10010484 Hájos Norbert true 10010484 true Hájos Norbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24336366 /api/publicationidentifier/24336366 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true RESTRICTED true IDENTICAL 10.1523/JNEUROSCI.0432-23.2023 https://doi.org/10.1523/JNEUROSCI.0432-23.2023 false true PublicationIdentifier 25272680 /api/publicationidentifier/25272680 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true RESTRICTED true IDENTICAL 184494 http://real.mtak.hu/184494 false true PublicationIdentifier 25509913 /api/publicationidentifier/25509913 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001148034900003 https://www.webofscience.com/wos/woscc/full-record/001148034900003 false true PublicationIdentifier 24596655 /api/publicationidentifier/24596655 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85174642101 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85174642101 false true PublicationIdentifier 24346286 /api/publicationidentifier/24346286 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37640552 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37640552&dopt=Abstract false true UploadedFile 581309 /api/uploadedfile/581309 true false true SjrRating 11402375 /api/sjrrating/11402375 16 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2801 /api/classificationexternal/2801 true 2801 true Q1 DIRECT true true /api/publication/34125713 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10065453"><a href="/gui2/?type=authors&mode=browse&sel=10065453" target="_blank">Nagy-Pál Petra (<span class="authorship-author-name">Nagy-Pál Petra</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10018814"><a href="/gui2/?type=authors&mode=browse&sel=10018814" target="_blank">Veres Judit M. (<span class="authorship-author-name">Veres Judit</span> <span class="authorAux-mtmt"> Idegélettan</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076935"><a href="/gui2/?type=authors&mode=browse&sel=10076935" target="_blank">Fekete Zsuzsanna (<span class="authorship-author-name">Fekete Zsuzsanna</span> <span class="authorAux-mtmt"> Elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10014208"><a href="/gui2/?type=authors&mode=browse&sel=10014208" target="_blank">Karlócai Mária R. (<span class="authorship-author-name">Karlócai Rita</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Laboratory of Cellular Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Filippo Weisz </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060502"><a href="/gui2/?type=authors&mode=browse&sel=10060502" target="_blank">Barabás Bence (<span class="authorship-author-name">Barabás Bence</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070310"><a href="/gui2/?type=authors&mode=browse&sel=10070310" target="_blank">Reéb Zsófia (<span class="authorship-author-name">Reéb Zsófia</span> <span class="authorAux-mtmt"> </span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd University">ELTE</span>/<span title="Faculty of Science">ELU FoS</span>/Doctoral School of Biology; <span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010484"><a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hájos Norbert ✉ (<span class="authorship-author-name">Hájos Norbert</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34125713" target="_blank">Structural organisation of perisomatic inhibition in the mouse medial prefrontal cortex</a></div> <div> <span class="journal-title">JOURNAL OF NEUROSCIENCE</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0270-6474">0270-6474</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1529-2401">1529-2401</a>)</span>: <span class="journal-volume">43</span> <span class="journal-issue">42</span> <span class="page"> pp 6972-6987 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_RESTRICTED" title=" Restricted "> <a style="color:blue" title="10.1523/JNEUROSCI.0432-23.2023" target="_blank" href="https://doi.org/10.1523/JNEUROSCI.0432-23.2023"> DOI </a> </span> <span class="id identifier oa_RESTRICTED" title=" Restricted "> <a style="color:blue" title="184494" target="_blank" href="http://real.mtak.hu/184494"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001148034900003" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001148034900003"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85174642101" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85174642101"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37640552" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37640552&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Neuroscience (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 10</span> | Independent citation: 9 | Self citation: 1 | Unknown citation: 0 | Number of citations in WoS: 10 | Number of citations in Scopus:&nbsp;7 | WoS/Scopus assigned:&nbsp;10 | Number of citations with DOI:&nbsp;10 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34125713&sort=publishedYear,desc&sort=title"> Number of cited publications: 33 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34125713</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (K131893) </div> <div class="lastModified">Last Modified: 2025.11.18. 12:22 Ilona Kósa (MTMT központi Admin, admin) </div> <div class="lockedBy">Centrally managed 2024.04.17. 16:19 Katalin Lévayné Deseő (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002]; National Research, Development and Innovation Office [K131893] Funding text: This work was supported by Hungarian Brain Research Program Grant 2017-1.2.1-NKP-2017-00002 and National Research, Development and Innovation Office Grant K131893. We thank Peter Foldi, Eva Krizsan, Orsolya Papp, ...</pre> </div></div>