https://m2.mtmt.hu/ eng 2026-04-16 23:07 JournalArticle 34125675 APPROVED true Funding Agency and Grant Number: National Research, Development and Innovation Office [K131893, RRF-2.3.1-21-2022-00011]; Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002] Funding text: This work was supported by National Research, Development and Innovation Office (K131893 and RRF-2.3.1-21-2022-00011) and Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002). 0 false 2026-03-12T09:39:22.795+0000 2025-11-18T11:23:08.677+0000 2023-09-05T07:58:33.838+0000 true 10065463 Turek Márta /api/admin/10065463 Admin true 2025-11-27T08:53:14.917+0000 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2024-04-17T13:06:06.113+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Veres, Judit M. Fear learning and aversive stimuli differentially change excitatory synaptic transmission in perisomatic inhibitory cells of the basal amygdala. true true /api/journal/10015931 REVIEWED true false 10015931 false 10015931 true 1662-5102 Journal FOREIGN 17 1120338 1120338 13 2023 Inhibitory circuits in the basal amygdala (BA) have been shown to play a crucial role in associative fear learning. How the excitatory synaptic inputs received by BA GABAergic interneurons are influenced by memory formation, a network parameter that may contribute to learning processes, is still largely unknown. Here, we investigated the features of excitatory synaptic transmission received by the three types of perisomatic inhibitory interneurons upon cue-dependent fear conditioning and aversive stimulus and tone presentations without association. Acute slices were prepared from transgenic mice: one group received tone presentation only (conditioned stimulus, CS group), the second group was challenged by mild electrical shocks unpaired with the CS (unsigned unconditioned stimulus, unsigned US group) and the third group was presented with the CS paired with the US (signed US group). We found that excitatory synaptic inputs (miniature excitatory postsynaptic currents, mEPSCs) recorded in distinct interneuron types in the BA showed plastic changes with different patterns. Parvalbumin (PV) basket cells in the unsigned US and signed US group received mEPSCs with reduced amplitude and rate in comparison to the only CS group. Coupling the US and CS in the signed US group caused a slight increase in the amplitude of the events in comparison to the unsigned US group, where the association of CS and US does not take place. Excitatory synaptic inputs onto cholecystokinin (CCK) basket cells showed a markedly different change from PV basket cells in these behavioral paradigms: only the decay time was significantly faster in the unsigned US group compared to the only CS group, whereas the amplitude of mEPSCs increased in the signed US group compared to the only CS group. Excitatory synaptic inputs received by PV axo-axonic cells showed the least difference in the three behavioral paradigm: the only significant change was that the rate of mEPSCs increased in the signed US group when compared to the only CS group. These results collectively show that associative learning and aversive stimuli unpaired with CS cause different changes in excitatory synaptic transmission in BA perisomatic interneuron types, supporting the hypothesis that they play distinct roles in the BA network operations upon pain information processing and fear memory formation. 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Hálózat-Idegélettani Kutatócsoport (HRN KOKI); Kísérleti Orvostudományi Kutatóintézet 8 16 3 8 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 109781556 /api/authorship/109781556 1 0.125 true false true Author 10018814 /api/author/10018814 Veres Judit true 10018814 true Veres Judit M. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781557 /api/authorship/109781557 2 0.125 true false Author 10076935 /api/author/10076935 Fekete Zsuzsanna true true Fekete Zsuzsanna true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781558 /api/authorship/109781558 3 0.125 false false Author 10067999 /api/author/10067999 Müller Kinga true true Müller Kinga true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781559 /api/authorship/109781559 4 0.125 false false Author 10039582 /api/author/10039582 Andrási Tibor true 10039582 true Andrasi Tibor true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781560 /api/authorship/109781560 5 0.125 false false Author 10059427 /api/author/10059427 Rovira Esteban Laura true 10059427 true Rovira-Esteban Laura true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781561 /api/authorship/109781561 6 0.125 false false Author 10060502 /api/author/10060502 Barabás Bence true 10060502 true Barabas Bence true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781562 /api/authorship/109781562 7 0.125 false false Author 10023475 /api/author/10023475 Papp Orsolya true 10023475 true Papp Orsolya I. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109781563 /api/authorship/109781563 8 0.125 false true true Author 10010484 /api/author/10010484 Hájos Norbert true 10010484 true Hajos Norbert true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24336196 /api/publicationidentifier/24336196 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true IDENTICAL 10.3389/fncel.2023.1120338 https://doi.org/10.3389/fncel.2023.1120338 false true PublicationIdentifier 24349987 /api/publicationidentifier/24349987 SwordSource 36 /api/publicationsource/36 PublicationSourceType 10007 /api/publicationsourcetype/10007 true true true REAL REAL http://real.mtak.hu/@@@ true true 36 true GOLD true IDENTICAL 172959 http://real.mtak.hu/172959 false true PublicationIdentifier 24507786 /api/publicationidentifier/24507786 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001067879300001 https://www.webofscience.com/wos/woscc/full-record/001067879300001 true true PublicationIdentifier 24507789 /api/publicationidentifier/24507789 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85171556773 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85171556773 true true PublicationIdentifier 24507792 /api/publicationidentifier/24507792 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37731462 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37731462&dopt=Abstract true true SjrRating 11361650 /api/sjrrating/11361650 25 0.49 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2804 /api/classificationexternal/2804 true 2804 true Q2 DIRECT true true /api/publication/34125675 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10018814"><a href="/gui2/?type=authors&mode=browse&sel=10018814" target="_blank">Veres Judit M. ✉ (<span class="authorship-author-name">Veres Judit</span> <span class="authorAux-mtmt"> Idegélettan</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10076935"><a href="/gui2/?type=authors&mode=browse&sel=10076935" target="_blank">Fekete Zsuzsanna<sup>*</sup> (<span class="authorship-author-name">Fekete Zsuzsanna</span> <span class="authorAux-mtmt"> Elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10067999"><a href="/gui2/?type=authors&mode=browse&sel=10067999" target="_blank">Müller Kinga (<span class="authorship-author-name">Müller Kinga</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies; <span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10039582"><a href="/gui2/?type=authors&mode=browse&sel=10039582" target="_blank">Andrasi Tibor (<span class="authorship-author-name">Andrási Tibor</span> <span class="authorAux-mtmt"> Elektrofiziológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059427"><a href="/gui2/?type=authors&mode=browse&sel=10059427" target="_blank">Rovira-Esteban Laura (<span class="authorship-author-name">Rovira Esteban Laura</span> <span class="authorAux-mtmt"> Neurobiology</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10060502"><a href="/gui2/?type=authors&mode=browse&sel=10060502" target="_blank">Barabas Bence (<span class="authorship-author-name">Barabás Bence</span> <span class="authorAux-mtmt"> Idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023475"><a href="/gui2/?type=authors&mode=browse&sel=10023475" target="_blank">Papp Orsolya I. (<span class="authorship-author-name">Papp Orsolya</span> <span class="authorAux-mtmt"> Idegélettan</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10010484"><a href="/gui2/?type=authors&mode=browse&sel=10010484" target="_blank">Hajos Norbert ✉ (<span class="authorship-author-name">Hájos Norbert</span> <span class="authorAux-mtmt"> Neurobiológia</span>) </a> </span> <span class="author-affil"><span title="Institute of Experimental Medicine">IEM</span>/Network Neurophysiology; Institute of Experimental Medicine</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34125675" target="_blank">Fear learning and aversive stimuli differentially change excitatory synaptic transmission in perisomatic inhibitory cells of the basal amygdala.</a></div> <div> <span class="journal-title">FRONTIERS IN CELLULAR NEUROSCIENCE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1662-5102">1662-5102</a>)</span>: <span class="journal-volume">17</span> <span class="page"> Paper 1120338. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3389/fncel.2023.1120338" target="_blank" href="https://doi.org/10.3389/fncel.2023.1120338"> DOI </a> </span> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="172959" target="_blank" href="http://real.mtak.hu/172959"> REAL </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001067879300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001067879300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85171556773" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85171556773"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37731462" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37731462&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Cellular and Molecular Neuroscience&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 1</span> | Independent citation: 1 | Self citation: 0 | Unknown citation: 0 | Number of citations in WoS: 1 | WoS/Scopus assigned:&nbsp;1 | Number of citations with DOI:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34125675&sort=publishedYear,desc&sort=title"> Number of cited publications: 20 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34125675</span> | <span class="status-data status-APPROVED"> Published </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> National Laboratory of Translational Neuroscience (TINL)(RRF-2.3.1-21-2022-00011), Recovery and Resilience Facility of the European Union within the framework of Programme Szécheny...(RRF-2.3.1-21-2022-00011), (RRF-2.3.1-21-2022-00011), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), Hungarian National Brain Research Program(2017-1.2.1-NKP-2017-00002), (K131893) Funder: NKFI </div> <div class="lastModified">Last Modified: 2025.11.18. 12:23 Ilona Kósa (MTMT központi Admin, admin) </div> <div class="lockedBy">Centrally managed 2024.04.17. 15:06 Katalin Lévayné Deseő (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Funding Agency and Grant Number: National Research, Development and Innovation Office [K131893, RRF-2.3.1-21-2022-00011]; Hungarian Brain Research Program [2017-1.2.1-NKP-2017-00002] Funding text: This work was supported by National Research, Development and Innovation Office (K131893 and RRF-2.3.1-21-2022-00011) and Hungarian Brain Research Program (2017-1.2.1-NKP-2017-00002).</pre> </div></div>