https://m2.mtmt.hu/ hun 2026-05-04 10:15 JournalArticle 34124238 VALIDATED true Laboratory of Experimental Rheumatology and Academic Division of Rheumatology, Department of Internal Medicine (DiMI), University of Genoa, Italy IRCCS Ospedale Policlinico San Martino, Genoa, Italy Reichman University, Herzelia, Israel Zabludowicz Center for Autoimmunity, Sheba Medical Center, Israel Department of Rheumatology and Clinical Immunology, University of Thessaly Medical School, Larissa, Greece Department of Medicine DIMED, Division of Rheumatology, University of Padua, Padua, Italy Department of Rheumatology and Clinical Immunology, Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary Department of Pharmacology and Pharmacotherapy, University of Pécs, Pécs, Hungary ELKH Chronic Pain Research Group, Pécs, Hungary Heart and Vascular Center, Semmelweis University, Budapest, Hungary Department of Genetics, Cell- and Immunobiology, Semmelweis University, Budapest, Hungary Hospital of the Hospitaller Order of Saint John of God, Budapest, Hungary Cited By :6 Export Date: 6 December 2024 CODEN: ARUEB Correspondence Address: Cutolo, M.; Laboratory of Experimental Rheumatology and Academic Division of Rheumatology, Italy; email: mcutolo@unige.it 0 false 2026-04-20T12:03:02.651+0000 2024-11-28T06:08:11.639+0000 2023-09-04T07:15:39.786+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 2026-04-05T09:38:17.925+0000 2024-11-28T06:08:11.948+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 Admin 10025544 /api/admin/10025544 Lévayné Deseő Katalin true 10025544 true 2025-06-04T22:15:15.115+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Cutolo, Maurizio To treat or not to treat rheumatoid arthritis with glucocorticoids? A reheated debate true true /api/journal/2149050 REVIEWED true false 2149050 false 2149050 true 1568-9972 1873-0183 Journal FOREIGN 23 1 103437 103437 5 2024 The therapeutic landscape of rheumatoid arthritis (RA) has rapidly evolved in the last few decades. At the same time, recommendations for the management of the disease suggest to minimize glucocorticoids (GCs) use in RA patients. Major concerns are the risk of long-term adverse events and the difficulties in discontinuing GCs once initiated. However, real-world data show that up to 50% of RA patients continue to take GCs during the disease course. Adverse events of GCs usually occur after a long-term use, which can limit the generalizability of randomized controlled trials (RCTs) proving no or minimal harm. Observational studies show conflicting results regarding the safety of GSs and are subjected to a high risk of bias, including indication bias. Thus, whether or not GCs should be used in the management of RA is still a matter of debate. The main reasons to support GCs use are the ability to rapidly suppress joint inflammation while waiting for the full effect of conventional synthetic disease-modifying antirheumatic drugs (csDMARD) and the acknowledged efficacy on radiographic progression in early RA. The main reasons to avoid GCs use in RA are that their potential risks may outweigh their benefits and there is no agreement on the minimal daily dosage of GC which can be considered safe. 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Farmakológiai és Farmakoterápiai Intézet (PTE / ÁOK); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Kardiológia Központ - Kardiológiai Tanszék (SE / AOK / K); Reumatológiai és Klinikai Immunológiai Tanszék (SE / AOK / K / BOK) 2 27 5 7 0 true 10025544 Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 109773428 /api/authorship/109773428 1 0.143 true false true Cutolo Maurizio true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109773429 /api/authorship/109773429 2 0.143 false false true Shoenfeld Yehuda true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109773430 /api/authorship/109773430 3 0.14285715 false false false Bogdanos Dimitrios P true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109773431 /api/authorship/109773431 4 0.14285715 false false false Gotelli Emanuele true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109773432 /api/authorship/109773432 5 0.14285715 false false false Salvato Mariangela true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109773433 /api/authorship/109773433 6 0.143 false false false Author 10087394 /api/author/10087394 Gunkl-Tóth Lilla true true Gunkl-Tóth Lilla true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109773434 /api/authorship/109773434 7 0.14285715 false true false Author 10025749 /api/author/10025749 Nagy György true 10025749 true Nagy György true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24332613 /api/publicationidentifier/24332613 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true PAY IDENTICAL 10.1016/j.autrev.2023.103437 https://doi.org/10.1016/j.autrev.2023.103437 false true PublicationIdentifier 26301463 /api/publicationidentifier/26301463 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001223987300001 https://www.webofscience.com/wos/woscc/full-record/001223987300001 true true PublicationIdentifier 24381026 /api/publicationidentifier/24381026 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85170429052 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85170429052 false true PublicationIdentifier 24332612 /api/publicationidentifier/24332612 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37652398 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37652398&dopt=Abstract false true Classification 12215 /api/classification/12215 true true Keyword 64 /api/keyword/64 true 64 true Keyword 8268 /api/keyword/8268 true 8268 true Keyword 15842 /api/keyword/15842 true 15842 true Keyword 20167 /api/keyword/20167 true 20167 true SjrRating 11472447 /api/sjrrating/11472447 22 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 2723 /api/classificationexternal/2723 true 2723 true D1 DIRECT true true /api/publication/34124238 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Cutolo Maurizio ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Shoenfeld Yehuda ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bogdanos Dimitrios P </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Gotelli Emanuele </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Salvato Mariangela </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10087394"><a href="/gui2/?type=authors&mode=browse&sel=10087394" target="_blank">Gunkl-Tóth Lilla (<span class="authorship-author-name">Gunkl-Tóth Lilla</span> <span class="authorAux-mtmt"> Fájdalom patomechanizmusának vizsgálata reumato...</span>) </a> </span> <span class="author-affil"><span title="Pécsi Tudományegyetem">PTE</span>/<span title="Általános Orvostudományi Kar">ÁOK</span>/Farmakológiai és Farmakoterápiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék; <span title="Pécsi Tudományegyetem">PTE</span>/<span title="Kutatócsoportok">KCS</span>/ELKH-PTE Krónikus Fájdalom Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10025749"><a href="/gui2/?type=authors&mode=browse&sel=10025749" target="_blank">Nagy György (<span class="authorship-author-name">Nagy György</span> <span class="authorAux-mtmt"> Immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Belgyógyászati és Onkológiai Klinika">BOK</span>/Reumatológiai és Klinikai Immunológiai Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34124238" target="_blank">To treat or not to treat rheumatoid arthritis with glucocorticoids? A reheated debate</a></div> <div> <span class="journal-title">AUTOIMMUNITY REVIEWS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1568-9972">1568-9972</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-0183">1873-0183</a>)</span>: <span class="journal-volume">23</span> <span class="journal-issue">1</span> <span class="page"> Paper 103437. 5 p. </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1016/j.autrev.2023.103437" target="_blank" href="https://doi.org/10.1016/j.autrev.2023.103437"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001223987300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001223987300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85170429052" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85170429052"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37652398" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37652398&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology and Allergy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Immunology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 26</span> | Független: 21 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 24 | Scopus jelölt:&nbsp;21 | WoS/Scopus jelölt:&nbsp;25 | DOI jelölt:&nbsp;26 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34124238&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 6 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34124238</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">PubMed XML</span> </div> <div class="funder"> (OTKA K131479) Támogató: OTKA, (TKP2021-EGA-29), Richter Gedeon Talentum Foundation </div> <div class="lastModified">Utolsó módosítás: 2024.11.28. 07:08 Milánkovics Róbert (PTE ÁOK admin 4) </div> <div class="lockedBy">Központi kezelésű 2025.06.05. 00:15 Lévayné Deseő Katalin (MTMT Központi admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Laboratory of Experimental Rheumatology and Academic Division of Rheumatology, Department of Internal Medicine (DiMI), University of Genoa, Italy IRCCS Ospedale Policlinico San Martino, Genoa, Italy Reichman University, Herzelia, Israel Zabludowicz Center for Autoimmunity, Sheba Medical Center, Israel ...</pre> </div></div>