At admission hemodynamic instability is associated with increased mortality and rebleeding rate in acute gastrointestinal bleeding : a systematic review and meta-analysis

https://m2.mtmt.hu/ eng 2026-06-27 23:38 JournalArticle 34123722 VALIDATED true 0 false 2026-06-23T13:36:47.853+0000 2026-04-13T11:46:30.978+0000 2023-09-02T19:05:21.232+0000 true 10081959 Szalóky-Siki Ágnes /api/admin/10081959 Admin Ágnes Szalóky-Siki (SE_ÁOK_Transzlációs_Admin5_SZSÁ, admin) true 2026-04-13T11:46:26.704+0000 2026-04-13T11:46:26.704+0000 2026-04-13T11:46:31.070+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Róbert Milánkovics (PTE ÁOK admin 4) true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Journal Article 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Survey paper (Journal Article) 102 true 1134514 true 1 /api/category/1 Category Scientific true 1 Tari, Edina At admission hemodynamic instability is associated with increased mortality and rebleeding rate in acute gastrointestinal bleeding : a systematic review and meta-analysis true true /api/journal/10036399 REVIEWED THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 1756-283X 1756-2848 true false 10036399 false 10036399 true 1756-283X 1756-2848 Journal FOREIGN 23 16 1 18 1 18 2023 Acute gastrointestinal bleeding (GIB) is a life-threatening event. Around 20-30% of patients with GIB will develop hemodynamic instability (HI).We aimed to quantify HI as a risk factor for the development of relevant end points in acute GIB.A systematic search was conducted in three medical databases in October 2021.Studies of GIB patients detailing HI as a risk factor for the investigated outcomes were selected. For the overall results, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated based on a random-effects model. Subgroups were formed based on the source of bleeding. The Quality of Prognostic Studies tool was used to assess the risk of bias.A total of 62 studies were eligible, and 39 were included in the quantitative synthesis. HI was found to be a risk factor for both in-hospital (OR: 5.48; CI: 3.99-7.52) and 30-day mortality (OR: 3.99; CI: 3.08-5.17) in upper GIB (UGIB). HI was also associated with higher in-hospital (OR: 3.68; CI: 2.24-6.05) and 30-day rebleeding rates (OR: 4.12; 1.83-9.31) among patients with UGIB. The need for surgery was also more frequent in hemodynamically compromised UGIB patients (OR: 3.65; CI: 2.84-4.68). In the case of in-hospital mortality, the risk of bias was high for 1 (4%), medium for 13 (48%), and low for 13 (48%) of the 27 included studies.Hemodynamically compromised patients have increased odds of all relevant untoward end points in GIB. Therefore, to improve the outcomes, adequate emergency care is crucial in HI.PROSPERO registration number: CRD42021285727. Funding 2030351 /api/funding/2030351 (TKP2021-EGA-23) Funder: Ministry for Innovation and Technology false true true 2023 true true true false true false GOLD 2026-06-23 true https://doi.org/10.1177/17562848231190970 13 0 13 11 3 13 13 11 13 13 13 11 11 11 2 0 13 11 13 11 0 1 1 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2025 0 7 7 7 7 2026 0 6 4 6 4 Q1 false false false false 2023-09-03T08:02:19.369+0000 Biofizikai és Sugárbiológiai Intézet (SE / AOK / I); Pankreász Betegségek Intézete (SE / AOK / K); Transzlációs Medicina Intézet (PTE / ÁOK); Transzlációs Medicina Központ (SE / KSZE) 6 35 4 7 0 true Language 10002 /api/language/10002 English Angol English true 2 true PersonAuthorship 109764700 /api/authorship/109764700 Tari, Edina [Tari, Edina (Gasztroenterológia), author] Centre for Translational Medicine (SU / KSZE); Institute of Pancreatic Diseases (SU / FM / C) 1 0.143 true false false Author 10088701 /api/author/10088701 Edina Tari (Gasztroenterológia) Tari Edina true true Tari Edina true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109764701 /api/authorship/109764701 Frim, Levente [Frim, Levente (Orvostudomány), author] Institute for Translational Medicine (UP / UPMS) 2 0.14285715 false false false Author 10090580 /api/author/10090580 Levente Frim (Orvostudomány) Frim Levente true true Frim Levente true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109764702 /api/authorship/109764702 Stolcz, Tünde 3 0.14285715 false false false Stolcz Tünde true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109764703 /api/authorship/109764703 Teutsch, Brigitta [Teutsch, Brigitta (Gasztroenterológia), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE) 4 0.143 false false false Author 10078049 /api/author/10078049 Brigitta Teutsch (Gasztroenterológia) Teutsch Brigitta true true Teutsch Brigitta true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109764704 /api/authorship/109764704 Veres, Dániel Sándor [Veres, Dániel (Biofizika), author] Departmnet of Biophysics and Radiation Biology (SU / FM / I); Centre for Translational Medicine (SU / KSZE) 5 0.143 false false false Author 10031347 /api/author/10031347 Dániel Veres (Biofizika) Veres Dániel true 10031347 true Veres Dániel Sándor true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109764705 /api/authorship/109764705 Hegyi, Péter [Hegyi, Péter (Gasztroenterológia), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE); Institute of Pancreatic Diseases (SU / FM / C) 6 0.143 false false false Author 10002629 /api/author/10002629 Péter Hegyi (Gasztroenterológia) Hegyi Péter true 10002629 true Hegyi Péter true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PersonAuthorship 109764706 /api/authorship/109764706 Erőss, Bálint ✉ [Erőss, Bálint Mihály (Gasztroenterológia), author] Institute for Translational Medicine (UP / UPMS); Centre for Translational Medicine (SU / KSZE); Institute of Pancreatic Diseases (SU / FM / C) 7 0.143 false true true Author 10064235 /api/author/10064235 Bálint Mihály Erőss (Gasztroenterológia) Erőss Bálint Mihály true 10064235 true Erőss Bálint true false false AuthorshipType 1 /api/authorshiptype/1 Author 0 true 0 true false true PublicationIdentifier 24331635 /api/publicationidentifier/24331635 DOI: 10.1177/17562848231190970 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1177/17562848231190970 https://doi.org/10.1177/17562848231190970 false true PublicationIdentifier 24374347 /api/publicationidentifier/24374347 WoS: 001057330200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001057330200001 https://www.webofscience.com/wos/woscc/full-record/001057330200001 false true PublicationIdentifier 24357237 /api/publicationidentifier/24357237 Scopus: 85169677045 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85169677045 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85169677045 false true PublicationIdentifier 24331634 /api/publicationidentifier/24331634 PubMed: 37655056 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37655056 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37655056&dopt=Abstract false true Keyword 3375201 /api/keyword/3375201 [Meta-analysis] true true SjrRating 11380103 /api/sjrrating/11380103 sjr:Q1 (2023) Scopus - Gastroenterology THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 1756-283X 1756-2848 28 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 2715 /api/classificationexternal/2715 Scopus - Gastroenterology true 2715 true Q1 DIRECT true true /api/publication/34123722 Tari Edina et al. At admission hemodynamic instability is associated with increased mortality and rebleeding rate in acute gastrointestinal bleeding : a systematic review and meta-analysis. (2023) THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 1756-283X 1756-2848 23 16 1-18<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <a href="/gui2/?type=authors&mode=browse&sel=10088701" target="_blank">Tari Edina (Tari Edina Gasztroenterológia) </a> SU/KSZE/Centre for Translational Medicine; SU/FM/C/Institute of Pancreatic Diseases ;    <a href="/gui2/?type=authors&mode=browse&sel=10090580" target="_blank">Frim Levente (Frim Levente Orvostudomány) </a> UP/UPMS/Institute for Translational Medicine ;    Stolcz Tünde ;    <a href="/gui2/?type=authors&mode=browse&sel=10078049" target="_blank">Teutsch Brigitta (Teutsch Brigitta Gasztroenterológia) </a> UP/UPMS/Institute for Translational Medicine; SU/KSZE/Centre for Translational Medicine ;    <a href="/gui2/?type=authors&mode=browse&sel=10031347" target="_blank">Veres Dániel Sándor (Veres Dániel Biofizika) </a> SU/FM/I/Departmnet of Biophysics and Radiation Biology; SU/KSZE/Centre for Translational Medicine ;    <a href="/gui2/?type=authors&mode=browse&sel=10002629" target="_blank">Hegyi Péter (Hegyi Péter Gasztroenterológia) </a> UP/UPMS/Institute for Translational Medicine; SU/KSZE/Centre for Translational Medicine; SU/FM/C/Institute of Pancreatic Diseases ;    <a href="/gui2/?type=authors&mode=browse&sel=10064235" target="_blank">Erőss Bálint ✉ (Erőss Bálint Mihály Gasztroenterológia) </a> UP/UPMS/Institute for Translational Medicine; SU/KSZE/Centre for Translational Medicine; SU/FM/C/Institute of Pancreatic Diseases </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34123722" target="_blank">At admission hemodynamic instability is associated with increased mortality and rebleeding rate in acute gastrointestinal bleeding : a systematic review and meta-analysis</a></div> <div> THERAPEUTIC ADVANCES IN GASTROENTEROLOGY (<a target="_blank" href="https://portal.issn.org/resource/ISSN/1756-283X">1756-283X</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1756-2848">1756-2848</a>): 23 16 pp 1-18 (2023) </div> <div class="pub-footer"> Language: English | <a style="color:blue" title="10.1177/17562848231190970" target="_blank" href="https://doi.org/10.1177/17562848231190970"> DOI </a> <a style="color:blue" title="001057330200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001057330200001"> WoS </a> <a style="color:blue" title="85169677045" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85169677045"> Scopus </a> <a style="color:blue" title="37655056" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37655056&dopt=Abstract"> PubMed </a> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Gastroenterology   Rank: Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> Citing papers: 13 | Independent citation: 11 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 11 | Number of citations in Scopus: 13 | WoS/Scopus assigned: 13 | Number of citations with DOI: 13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34123722&sort=publishedYear,desc&sort=title"> Number of cited publications: 1 </a> </div> <div class="mtid">Publication: 34123722 | Validated Core Citing | Journal Article ( Survey paper ) | Scientific | kézi felvitel </div> <div class="funder"> (TKP2021-EGA-23) Funder: Ministry for Innovation and Technology </div> <div class="lastModified">Last Modified: 2026.04.13. 13:46 Róbert Milánkovics (PTE ÁOK admin 4) </div> </div></div>