https://m2.mtmt.hu/ hun 2026-05-02 08:55 JournalArticle 34123133 VALIDATED true Export Date: 20 September 2023 CODEN: MOLEF Correspondence Address: Forró, E.; Institute of Pharmaceutical Chemistry, Eötvös u. 6, Hungary; email: forro.eniko@szte.hu Funding details: Hungarian Scientific Research Fund, OTKA, K-138871 Funding details: Emberi Eroforrások Minisztériuma, EMMI, TKP-2021-EGA-32 Funding text 1: The authors’ thanks are due to the Hungarian Research Foundation (OTKA No. K-138871) and the Ministry of Human Capacities, Hungary, grant TKP-2021-EGA-32. 0 false 2025-12-31T21:12:22.443+0000 2024-02-09T18:40:39.703+0000 2023-09-01T13:01:03.435+0000 true 10079694 Lázárné Zalán Zita /api/admin/10079694 Admin Lázárné Zalán Zita (SZTE admin5 GYTK Gyógyszerkémiai Intézet) true 2024-02-09T18:40:40.256+0000 2024-02-09T18:40:40.256+0000 2023-09-01T13:06:32.624+0000 true 10079694 Lázárné Zalán Zita /api/admin/10079694 Admin Lázárné Zalán Zita (SZTE admin5 GYTK Gyógyszerkémiai Intézet) true 2023-09-04T06:41:14.687+0000 true 10083973 Szalai Fruzsina /api/admin/10083973 Admin Szalai Fruzsina (SZTE admin5) true true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType Összefoglaló cikk (Folyóiratcikk) 102 true 1134514 true 1 /api/category/1 Category Tudományos true 1 Orsy, György true true /api/journal/25013 REVIEWED MOLECULES 1431-5157 1420-3049 true false 25013 false 25013 true 1431-5157 1420-3049 Journal FOREIGN 28 17 6362 6362 14 2023 This report reviews the most important lipase-catalyzed strategies for the preparation of pharmaceutically and chemically important tetrahydroisoquinoline and tetrahydro-β-carboline enantiomers through O-acylation of the primary hydroxy group, N-acylation of the secondary amino group, and COOEt hydrolysis of the corresponding racemic compounds with simple molecular structure, which have been reported during the last decade. A brief introduction describes the importance and synthesis of tetrahydroisoquinoline and tetrahydro-β-carboline derivatives, and it formulates the objectives of this compilation. The strategies are presented in chronological order, classified according to function of the reaction type, as kinetic and dynamic kinetic resolutions, in the main text. These reactions result in the desired products with excellent ee values. The pharmacological importance of the products together with their synthesis is given in the main text. The enzymatic hydrolysis of the hydrochloride salts as racemates of the starting amino carboxylic esters furnished the desired enantiomeric amino carboxylic acids quantitatively. The enzymatic reactions, performed in tBuOMe or H2O as usable solvents, and the transformations carried out in a continuous-flow system, indicate clear advantages, including atom economy, reproducibility, safer solvents, short reaction time, rapid heating and compression vs. shaker reactions. These features are highlighted in the main text. 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(2023) MOLECULES 1431-5157 1420-3049 28 17<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10055345"><a href="/gui2/?type=authors&mode=browse&sel=10055345" target="_blank">Orsy György (<span class="authorship-author-name">Orsy György</span> <span class="authorAux-mtmt"> áramlásos kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerkémiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002835"><a href="/gui2/?type=authors&mode=browse&sel=10002835" target="_blank">Forró Enikő ✉ (<span class="authorship-author-name">Forró Enikő</span> <span class="authorAux-mtmt"> Szerves kémia</span>) </a> </span> <span class="author-affil"><span title="Szegedi Tudományegyetem">SZTE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Gyógyszerkémiai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34123133" target="_blank">Lipase-Catalyzed Strategies for the Preparation of Enantiomeric THIQ and THβC Derivatives: Green Aspects</a></div> <div> <span class="journal-title">MOLECULES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1431-5157">1431-5157</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1420-3049">1420-3049</a>)</span>: <span class="journal-volume">28</span> <span class="journal-issue">17</span> <span class="page"> Paper 6362. 14 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.3390/molecules28176362" target="_blank" href="https://doi.org/10.3390/molecules28176362"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001064199300001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001064199300001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85170358675" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85170358675"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37687191" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37687191&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:black" title="https://www.mdpi.com/1420-3049/28/17/6362" target="_blank" href="https://www.mdpi.com/1420-3049/28/17/6362"> Egyéb URL </a> </span> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="28166" target="_blank" href="http://publicatio.bibl.u-szeged.hu/28166"> SZTE Publicatio </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Analytical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Chemistry (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Pharmaceutical Science&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Drug Discovery&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Medicine&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q3</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 2</span> | Független: 2 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;2 | WoS/Scopus jelölt:&nbsp;2 | DOI jelölt:&nbsp;2 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34123133&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 10 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34123133</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K 138871) Támogató: NKFI, (TKP2021-EGA-32) Támogató: NKFIH </div> <div class="lastModified">Utolsó módosítás: 2024.02.09. 19:40 Lázárné Zalán Zita (SZTE admin5 GYTK Gyógyszerkémiai Intézet) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Export Date: 20 September 2023 CODEN: MOLEF Correspondence Address: Forró, E.; Institute of Pharmaceutical Chemistry, Eötvös u. 6, Hungary; email: forro.eniko@szte.hu Funding details: Hungarian Scientific Research Fund, OTKA, K-138871 Funding details: Emberi Eroforrások Minisztériuma, EMMI, TKP-2021-...</pre> </div></div>