https://m2.mtmt.hu/ hun 2026-09-20 21:18 JournalArticle 34122547 VALIDATED true Funding Agency and Grant Number: National Research, Development and Innovation Office: NKFIH [K 120342, FK 125302, K 135712, K-142904, EFOP-1.8.0-VEKOP-17-2017-0000]; ELTE Thematic Excellence Programme 2020; National Research,Development and Innovation Office [VEKOP-2.3.3-15-2017-00020]; 2018-1.2.1-NKP funding scheme [TKP2020-IKA-05]; [ELTE2018-1.2.1-NKP-2018-00005] Funding text: This research was funded by grants from the National Research, Development and Innovation Office: NKFIH, K 120342 (PI:A.A.), FK 125302 (PI: E.R.), K 135712 (PI: I.B.), K-142904 (PI: S.B.); EFOP-1.8.0-VEKOP-17-2017-0000 (B.S. and S.B.); VEKOP-2.3.3-15-2017-00020. This workwas supported by the ELTE Thematic Excellence Programme 2020 Supported by National Research,Development and Innovation Office TKP2020-IKA-05. (B.S. and S.B.). S.B. is grateful for the ELTE2018-1.2.1-NKP-2018-00005 project (under the 2018-1.2.1-NKP funding scheme) 0 false 2026-06-01T14:59:22.488+0000 2025-01-28T08:43:41.471+0000 2023-09-01T06:49:49.954+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin Áncsán Gizella (SE admin) true 10015206 2026-06-01T14:56:29.962+0000 2025-01-28T08:43:41.655+0000 true 10015544 Csajbók Edit /api/admin/10015544 Admin Csajbók Edit (SE_KK_Admin5_CSE, admin) true 10015544 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Felegyi-Tóth, Csenge Anna true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 17 13489 13489 17 2023 Four cyclic diarylheptanoids—carpinontriols A (1) and B (2), giffonin X (3) and 3,12,17-trihydroxytricyclo [12.3.1.12,6]nonadeca-1(18),2(19),3,5,14,16-hexaene-8,11-dione (4)—were isolated from Carpinus betulus (Betulaceae). Chemical stability of the isolated diarylheptanoids was evaluated as a function of storage temperature (−15, 5, 22 °C) and time (12 and 23 weeks). The effect of the solvent and the pH (1.2, 6.8, 7.4) on the stability of these diarylheptanoids was also investigated. Compounds 2 and 4 showed good stability both in aqueous and methanolic solutions at all investigated temperatures. Only 2 was stable at all three studied biorelevant pH values. Degradation products of 1 and 3 were formed by the elimination of a water molecule from the parent compounds, as confirmed by ultrahigh-performance liquid chromatography–high-resolution tandem mass spectrometry (UHPLC-HR-MS). The permeability of the compounds across biological membranes was evaluated by the parallel artificial membrane permeability assay (PAMPA). Compound 3 possesses a logPe value of −5.92 ± 0.04 in the blood–brain barrier-specific PAMPA-BBB study, indicating that it may be able to cross the blood–brain barrier via passive diffusion. The in vitro antiproliferative activity of the compounds was investigated against five human cancer cell lines, confirming that 1 inhibits cell proliferation in A2058 human metastatic melanoma cells. Funding 2031286 /api/funding/2031286 (K 120342) false true Funding 2031287 /api/funding/2031287 (FK 125302) false true Funding 2031288 /api/funding/2031288 OTKA(K-135712) false true Funding 2031289 /api/funding/2031289 (K-142904) false true Funding 2031290 /api/funding/2031290 (EFOP-1.8.0-VEKOP-17-2017-00001) false true Funding 2031291 /api/funding/2031291 (VEKOP-2.3.3-15-2017-00020) Támogató: EU false true Funding 2031292 /api/funding/2031292 (TKP2020-IKA-05) false true true 2023 true true true false true false GOLD 2026-06-01 true https://doi.org/10.3390/ijms241713489 1 0 1 0 1 1 1 1 1 1 1 0 0 0 1 0 1 0 1 0 0 7 7 Folyóiratcikk Journal Article 24 1 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 1 0 1 0 D1 false 10032430,10053151,10020703 false false false 2023-09-14T11:46:24.354+0000 ELKH-ELTE Peptidkémiai Kutatócsoport (ELTE / TTK / KI); Farmakognóziai Intézet (SE / GYTK); Növényszervezettani Tanszék (ELTE / TTK / Bio_I) 7 21 3 9 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 109757299 /api/authorship/109757299 Felegyi-Tóth, Csenge Anna [Felegyi-Tóth, Csenge Anna (Farmakognózia), szerző] Farmakognóziai Intézet (SE / GYTK) 1 0.111 true false false Author 10065826 /api/author/10065826 Felegyi-Tóth Csenge Anna (Farmakognózia) Felegyi-Tóth Csenge Anna true true Felegyi-Tóth Csenge Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109757300 /api/authorship/109757300 Heilmann, Tímea 2 0.11111111 false false false Heilmann Tímea true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109757301 /api/authorship/109757301 Buda, Eszter 3 0.111 false false false Buda Eszter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109757302 /api/authorship/109757302 Stipsicz, Bence [Stipsicz, Bence András (immunológia, pept...), szerző] ELKH-ELTE Peptidkémiai Kutatócsoport (ELTE / TTK / KI) 4 0.111 false false Author 10086277 /api/author/10086277 Stipsicz Bence András (immunológia, peptidkémia) Stipsicz Bence András true true Stipsicz Bence true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109757303 /api/authorship/109757303 Simon, Alexandra [Simon, Alexandra (Gyógyszerészeti t...), szerző] Farmakognóziai Intézet (SE / GYTK) 5 0.111 false false false Author 10069990 /api/author/10069990 Simon Alexandra (Gyógyszerészeti tudományok) Simon Alexandra true true Simon Alexandra true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109757304 /api/authorship/109757304 Boldizsár, Imre [Boldizsár, Imre (Farmakobotanika), szerző] Farmakognóziai Intézet (SE / GYTK); Növényszervezettani Tanszék (ELTE / TTK / Bio_I) 6 0.111 false false Author 10020703 /api/author/10020703 Boldizsár Imre (Farmakobotanika) Boldizsár Imre true 10020703 true Boldizsár Imre true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109757305 /api/authorship/109757305 Bősze, Szilvia [Bősze, Szilvia (Peptidkémia), szerző] ELKH-ELTE Peptidkémiai Kutatócsoport (ELTE / TTK / KI) 7 0.111 false false Author 10002049 /api/author/10002049 Bősze Szilvia (Peptidkémia) Bősze Szilvia true 10002049 true Bősze Szilvia true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109757306 /api/authorship/109757306 Riethmüller, Eszter [Riethmüller, Eszter (Gyógyszerészeti t...), szerző] Farmakognóziai Intézet (SE / GYTK) 8 0.111 false false false Author 10053151 /api/author/10053151 Riethmüller Eszter (Gyógyszerészeti tudományok) Riethmüller Eszter true 10053151 true Riethmüller Eszter true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109757307 /api/authorship/109757307 Alberti, Ágnes ✉ [Alberti, Ágnes (Farmakognózia), szerző] Farmakognóziai Intézet (SE / GYTK) 9 0.111 false true true Author 10032430 /api/author/10032430 Alberti Ágnes (Farmakognózia) Alberti Ágnes true 10032430 true Alberti Ágnes true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24328921 /api/publicationidentifier/24328921 DOI: 10.3390/ijms241713489 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms241713489 https://doi.org/10.3390/ijms241713489 false true PublicationIdentifier 24440234 /api/publicationidentifier/24440234 WoS: 001070094200001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001070094200001 https://www.webofscience.com/wos/woscc/full-record/001070094200001 false true PublicationIdentifier 24376597 /api/publicationidentifier/24376597 Scopus: 85170287230 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85170287230 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85170287230 false true PublicationIdentifier 24407390 /api/publicationidentifier/24407390 PubMed: 37686297 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37686297 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37686297&dopt=Abstract true true Classification 12197 /api/classification/12197 Gyógyszerészet, farmakogenomika, gyógyszerkutatás és tervezés, gyógyszeres kezelés true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 44736390 /api/reference/44736390 1. 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 17<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10065826"><a href="/gui2/?type=authors&mode=browse&sel=10065826" target="_blank">Felegyi-Tóth Csenge Anna (<span class="authorship-author-name">Felegyi-Tóth Csenge Anna</span> <span class="authorAux-mtmt"> Farmakognózia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Heilmann Tímea </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Buda Eszter </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10086277"><a href="/gui2/?type=authors&mode=browse&sel=10086277" target="_blank">Stipsicz Bence (<span class="authorship-author-name">Stipsicz Bence András</span> <span class="authorAux-mtmt"> immunológia, peptidkémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/ELKH-ELTE Peptidkémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10069990"><a href="/gui2/?type=authors&mode=browse&sel=10069990" target="_blank">Simon Alexandra (<span class="authorship-author-name">Simon Alexandra</span> <span class="authorAux-mtmt"> Gyógyszerészeti tudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020703"><a href="/gui2/?type=authors&mode=browse&sel=10020703" target="_blank">Boldizsár Imre (<span class="authorship-author-name">Boldizsár Imre</span> <span class="authorAux-mtmt"> Farmakobotanika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet; <span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Biológiai Intézet">Bio_I</span>/Növényszervezettani Tanszék</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002049"><a href="/gui2/?type=authors&mode=browse&sel=10002049" target="_blank">Bősze Szilvia (<span class="authorship-author-name">Bősze Szilvia</span> <span class="authorAux-mtmt"> Peptidkémia</span>) </a> </span> <span class="author-affil"><span title="Eötvös Loránd Tudományegyetem">ELTE</span>/<span title="Természettudományi Kar">TTK</span>/<span title="Kémiai Intézet">KI</span>/ELKH-ELTE Peptidkémiai Kutatócsoport</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053151"><a href="/gui2/?type=authors&mode=browse&sel=10053151" target="_blank">Riethmüller Eszter (<span class="authorship-author-name">Riethmüller Eszter</span> <span class="authorAux-mtmt"> Gyógyszerészeti tudományok</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032430"><a href="/gui2/?type=authors&mode=browse&sel=10032430" target="_blank">Alberti Ágnes ✉ (<span class="authorship-author-name">Alberti Ágnes</span> <span class="authorAux-mtmt"> Farmakognózia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Gyógyszerésztudományi Kar">GYTK</span>/Farmakognóziai Intézet</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34122547" target="_blank">Evaluation of the Chemical Stability, Membrane Permeability and Antiproliferative Activity of Cyclic Diarylheptanoids from European Hornbeam (Carpinus betulus L.)</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">17</span> <span class="page"> Paper 13489. 17 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms241713489" target="_blank" href="https://doi.org/10.3390/ijms241713489"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001070094200001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001070094200001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85170287230" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85170287230"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37686297" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37686297&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 1</span> | Független: 0 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 1 | Scopus jelölt:&nbsp;1 | WoS/Scopus jelölt:&nbsp;1 | DOI jelölt:&nbsp;1 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34122547&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 7 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34122547</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (K 120342) Támogató: NKFIH, (FK 125302), OTKA(K-135712), (K-142904), (EFOP-1.8.0-VEKOP-17-2017-00001), (VEKOP-2.3.3-15-2017-00020) Támogató: EU, (TKP2020-IKA-05) </div> <div class="lastModified">Utolsó módosítás: 2025.01.28. 09:43 Csajbók Edit (SE_KK_Admin5_CSE, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: National Research, Development and Innovation Office: NKFIH [K 120342, FK 125302, K 135712, K-142904, EFOP-1.8.0-VEKOP-17-2017-0000]; ELTE Thematic Excellence Programme 2020; National Research,Development and Innovation Office [VEKOP-2.3.3-15-2017-00020]; 2018-1.2.1-NKP funding scheme [TKP2020-IKA-05]; [ELTE2018-1.2.1-NKP-2018-00005] Funding text: T...</pre> </div></div>