The present Ph.D. work has been planned to accomplish two major goals. In view of
the significance of fluorine-substituted compounds, the first aim was to synthesize
a selection of (±)-β-amino carboxylic ester hydrochloride salts 3a–e, then to generate
an appropriate lipase-catalyzed method for their resolution through hydrolysis, furnishing
enantiopure new β-fluorophenyl-substituted β-amino acids (S)-5a–e and unreacted β-amino
esters (R)-4a–e. The second objective of my work was a comparative investigation of
different green strategies and then to build an environmentally benign CALB-catalyzed
hydrolysis of cis carbocyclic amino esters 6–9.
