https://m2.mtmt.hu/ hun 2026-09-23 09:49 JournalArticle 34110644 VALIDATED true Funding Agency and Grant Number: Hungarian National Research, Development, and Innovation Office (HNRDI [NN 114460]; Semmelweis University Dean's Award 2015; [TKP2021-NVA-15 HNRDI] Funding text: This research was funded by the Hungarian National Research, Development, and Innovation Office (HNRDI grant NN 114460 to S.K. and K.N.) and the Semmelweis University Dean's Award 2015 (to K.N. and B.M.). Biobanking was supported by the TKP2021-NVA-15 HNRDI grant to Semmelweis University. 0 false 2026-05-23T04:09:09.087+0000 2024-07-31T09:16:47.540+0000 2023-08-25T09:49:21.974+0000 true 10065395 Cakir Ugur /api/admin/10065395 Admin Cakir Ugur (SE_AOK_Bőr-, Nemikórtani és Bőronkológiai Klinika_Admin5_CU, admin) true 2025-01-14T12:50:26.422+0000 2024-07-31T09:16:47.835+0000 true 10022176 Laczik Cecilia /api/admin/10022176 Admin Laczik Cecilia (SE_AOK_1Patológia_Admin5_LC, admin) true 10022176 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Hajdara, Anna true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 16 12893 12893 17 2023 The tumor microenvironment (TME) has gained considerable scientific attention by playing a role in immunosuppression and tumorigenesis. Besides tumor cells, TME is composed of various other cell types, including cancer-associated fibroblasts (CAFs or MAFs when referring to melanoma-derived CAFs) and tumor-infiltrating lymphocytes (TILs), a subpopulation of which is labeled as γδ T cells. Since the current anti-cancer therapies using γδ T cells in various cancers have exhibited mixed treatment responses, to better understand the γδ T cell biology in melanoma, our research group aimed to investigate whether activated γδ T cells are capable of killing MAFs. To answer this question, we set up an in vitro platform using freshly isolated Vδ2-type γδ T cells and cultured MAFs that were biobanked from our melanoma patients. This study proved that the addition of zoledronic acid (1–2.5 µM) to the γδ T cells was necessary to drive MAFs into apoptosis. The MAF cytotoxicity of γδ T cells was further enhanced by using the stimulatory clone 20.1 of anti-BTN3A1 antibody but was reduced when anti-TCR γδ or anti-BTN2A1 antibodies were used. Since the administration of zoledronic acid is safe and tolerable in humans, our results provide further data for future clinical studies on the treatment of melanoma. Funding 2030425 /api/funding/2030425 (NN 114460) Támogató: OTKA false true Funding 2030426 /api/funding/2030426 János Bolyai Research Scholarship of the Hungarian Academy of Sciences(TKP2021-NVA-15) false true true true 2023 true true true false true false GOLD 2026-05-23 true https://doi.org/10.3390/ijms241612893 8 0 8 8 0 8 7 8 7 8 8 8 8 8 0 0 8 8 8 8 0 2 2 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2024 0 4 4 4 4 2025 0 3 3 3 3 2026 0 1 1 1 1 D1 false 10063824,10031103,10040311,10029946 false false false 2023-09-03T13:35:22.910+0000 Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K); Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I); Információs Technológiai és Bionikai Kar (PPKE); Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I); Roska Tamás Műszaki és Természettudományi Dokto... (PPKE / ITK) 10 28 5 11 0 true Language 10002 /api/language/10002 Angol Angol English true 2 true PersonAuthorship 109688634 /api/authorship/109688634 Hajdara, Anna [Hajdara, Anna (biológia tudományág), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K); Roska Tamás Műszaki és Természettudományi Dokto... (PPKE / ITK) 1 0.091 true false false Author 10062901 /api/author/10062901 Hajdara Anna (biológia tudományág) Hajdara Anna true 10062901 true Hajdara Anna true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688635 /api/authorship/109688635 Çakır, Uğur [Cakir, Ugur (Bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 2 0.091 false false false Author 10063824 /api/author/10063824 Cakir Ugur (Bőrgyógyászat) Cakir Ugur true 10063824 true Çakır Uğur true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688636 /api/authorship/109688636 Érsek, Barbara [Molnár-Érsek, Barbara (immunológia), szerző] Genetikai, Sejt- és Immunbiológiai Intézet (SE / AOK / I) 3 0.091 false false false Author 10031103 /api/author/10031103 Molnár-Érsek Barbara (immunológia) Molnár-Érsek Barbara true 10031103 true Érsek Barbara true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688637 /api/authorship/109688637 Silló, Pálma [Silló, Pálma (bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 4 0.091 false false false Author 10027937 /api/author/10027937 Silló Pálma (bőrgyógyászat) Silló Pálma true 10027937 true Silló Pálma true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688638 /api/authorship/109688638 Széky, Balázs [Széky, Balázs (biológia), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K); Roska Tamás Műszaki és Természettudományi Dokto... (PPKE / ITK) 5 0.091 false false false Author 10053959 /api/author/10053959 Széky Balázs (biológia) Széky Balázs true 10053959 true Széky Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688639 /api/authorship/109688639 Barna, Gábor [Barna, Gábor (Hematologia), szerző] Patológiai és Kísérleti Rákkutató Intézet (SE / AOK / I) 6 0.091 false false false Author 10023553 /api/author/10023553 Barna Gábor (Hematologia) Barna Gábor true 10023553 true Barna Gábor true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688640 /api/authorship/109688640 Faqi, Shaaban 7 0.09090909 false false false Faqi Shaaban true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688641 /api/authorship/109688641 Gyöngy, Miklós [Gyöngy, Miklós (Jelfeldolgozás), szerző] Információs Technológiai és Bionikai Kar (PPKE) 8 0.091 false false false Author 10020416 /api/author/10020416 Gyöngy Miklós (Jelfeldolgozás) Gyöngy Miklós true 10020416 true Gyöngy Miklós true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688642 /api/authorship/109688642 Kárpáti, Sarolta [Kárpáti, Sarolta (Bõrgyógyászat, ge...), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 9 0.091 false false false Author 10002737 /api/author/10002737 Kárpáti Sarolta (Bõrgyógyászat, genetika) Kárpáti Sarolta true 10002737 true Kárpáti Sarolta true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688643 /api/authorship/109688643 Németh, Krisztián [Németh, Krisztián (Bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 10 0.091 false false false Author 10040311 /api/author/10040311 Németh Krisztián (Bőrgyógyászat) Németh Krisztián true 10040311 true Németh Krisztián true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109688644 /api/authorship/109688644 Mayer, Balázs ✉ [Mayer, Balázs (bőrgyógyászat), szerző] Bőr-, Nemikórtani és Bőronkológiai Klinika (SE / AOK / K) 11 0.091 false true true Author 10029946 /api/author/10029946 Mayer Balázs (bőrgyógyászat) Mayer Balázs true 10029946 true Mayer Balázs true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24299064 /api/publicationidentifier/24299064 DOI: 10.3390/ijms241612893 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms241612893 https://doi.org/10.3390/ijms241612893 false true PublicationIdentifier 24430862 /api/publicationidentifier/24430862 WoS: 001057703500001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001057703500001 https://www.webofscience.com/wos/woscc/full-record/001057703500001 true true PublicationIdentifier 24334776 /api/publicationidentifier/24334776 Scopus: 85168751314 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85168751314 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85168751314 true true PublicationIdentifier 24334778 /api/publicationidentifier/24334778 PubMed: 37629075 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37629075 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37629075&dopt=Abstract true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 44588292 /api/reference/44588292 1. 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 16<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10062901"><a href="/gui2/?type=authors&mode=browse&sel=10062901" target="_blank">Hajdara Anna (<span class="authorship-author-name">Hajdara Anna</span> <span class="authorAux-mtmt"> biológia tudományág</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika; <span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Roska Tamás Műszaki és Természettudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10063824"><a href="/gui2/?type=authors&mode=browse&sel=10063824" target="_blank">Çakır Uğur (<span class="authorship-author-name">Cakir Ugur</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10031103"><a href="/gui2/?type=authors&mode=browse&sel=10031103" target="_blank">Érsek Barbara (<span class="authorship-author-name">Molnár-Érsek Barbara</span> <span class="authorAux-mtmt"> immunológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Genetikai, Sejt- és Immunbiológiai Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10027937"><a href="/gui2/?type=authors&mode=browse&sel=10027937" target="_blank">Silló Pálma (<span class="authorship-author-name">Silló Pálma</span> <span class="authorAux-mtmt"> bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10053959"><a href="/gui2/?type=authors&mode=browse&sel=10053959" target="_blank">Széky Balázs (<span class="authorship-author-name">Széky Balázs</span> <span class="authorAux-mtmt"> biológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika; <span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/<span title="Információs Technológiai és Bionikai Kar">ITK</span>/Roska Tamás Műszaki és Természettudományi Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023553"><a href="/gui2/?type=authors&mode=browse&sel=10023553" target="_blank">Barna Gábor (<span class="authorship-author-name">Barna Gábor</span> <span class="authorAux-mtmt"> Hematologia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Patológiai és Kísérleti Rákkutató Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Faqi Shaaban </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10020416"><a href="/gui2/?type=authors&mode=browse&sel=10020416" target="_blank">Gyöngy Miklós (<span class="authorship-author-name">Gyöngy Miklós</span> <span class="authorAux-mtmt"> Jelfeldolgozás</span>) </a> </span> <span class="author-affil"><span title="Pázmány Péter Katolikus Egyetem">PPKE</span>/Információs Technológiai és Bionikai Kar</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10002737"><a href="/gui2/?type=authors&mode=browse&sel=10002737" target="_blank">Kárpáti Sarolta (<span class="authorship-author-name">Kárpáti Sarolta</span> <span class="authorAux-mtmt"> Bõrgyógyászat, genetika</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10040311"><a href="/gui2/?type=authors&mode=browse&sel=10040311" target="_blank">Németh Krisztián (<span class="authorship-author-name">Németh Krisztián</span> <span class="authorAux-mtmt"> Bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10029946"><a href="/gui2/?type=authors&mode=browse&sel=10029946" target="_blank">Mayer Balázs ✉ (<span class="authorship-author-name">Mayer Balázs</span> <span class="authorAux-mtmt"> bőrgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Bőr-, Nemikórtani és Bőronkológiai Klinika</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34110644" target="_blank">Targeting Melanoma-Associated Fibroblasts (MAFs) with Activated γδ (Vδ2) T Cells: An In Vitro Cytotoxicity Model</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">16</span> <span class="page"> Paper 12893. 17 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms241612893" target="_blank" href="https://doi.org/10.3390/ijms241612893"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001057703500001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001057703500001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85168751314" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85168751314"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37629075" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37629075&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 8</span> | Független: 8 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 8 | Scopus jelölt:&nbsp;7 | WoS/Scopus jelölt:&nbsp;8 | DOI jelölt:&nbsp;7 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34110644&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34110644</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (NN 114460) Támogató: OTKA, János Bolyai Research Scholarship of the Hungarian Academy of Sciences(TKP2021-NVA-15) </div> <div class="lastModified">Utolsó módosítás: 2024.07.31. 11:16 Laczik Cecilia (SE_AOK_1Patológia_Admin5_LC, admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: Hungarian National Research, Development, and Innovation Office (HNRDI [NN 114460]; Semmelweis University Dean's Award 2015; [TKP2021-NVA-15 HNRDI] Funding text: This research was funded by the Hungarian National Research, Development, and Innovation Office (HNRDI grant NN 114460 to S.K. and K.N.) and the Semmelweis University Dean's Award 2015 (to ...</pre> </div></div>