Cyclosporine A Decreases Dryness-Induced Hyperexcitability of Corneal Cold-Sensitive Nerve Terminals

https://m2.mtmt.hu/ hun 2026-09-22 06:50 JournalArticle 34106852 VALIDATED true 0 false 2026-08-18T09:41:47.670+0000 2025-07-29T09:12:49.491+0000 2023-08-22T11:57:57.165+0000 true 10015206 Áncsán Gizella /api/admin/10015206 Admin Áncsán Gizella (SE admin) true 10015206 2025-07-29T09:12:30.867+0000 2025-07-29T09:12:30.867+0000 2023-09-03T05:50:44.108+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin Milánkovics Róbert (PTE ÁOK admin 4) true 10039043 Admin 10003134 /api/admin/10003134 Wolf György (MTMT Központi admin) Wolf György true 10003134 true 2025-12-18T14:33:13.723+0000 true false true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType Folyóiratcikk 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType Szakcikk (Folyóiratcikk) 101 true 10000059 true 1 /api/category/1 Category Tudományos true 1 Gyenes, Andrea Cyclosporine A Decreases Dryness-Induced Hyperexcitability of Corneal Cold-Sensitive Nerve Terminals true true /api/journal/10003252 REVIEWED INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 true false 10003252 false 10003252 true 1661-6596 1422-0067 Journal FOREIGN 24 16 13025 13025 13 2023 Cyclosporine A (CsA) is used for the treatment of dry eye (DE) with good clinical results, improving tear secretion and decreasing subjective symptoms. These effects are attributed to the improved tear film dynamics, but there are no data on the effect of CsA on the abnormal sensory nerve activity characteristic in DE. Our purpose was to evaluate the CsA effect on the enhanced activity of corneal cold thermoreceptors in a tear-deficient DE animal model using in vitro extracellular recording of cold thermoreceptors nerve terminal impulses (NTIs) before and in the presence of CsA. NTI shape was also analyzed. Blinking frequency and tearing rate were also measured in awake animals before and after topical CsA. CsA increased the tearing and blinking of treated animals. CsA significantly decreased the peak response to cold of cold thermoreceptors. Neither their spontaneous NTIs discharge rate nor their cooling threshold were modified. CsA also seemed to reverse some of the changes in NTI shape induced by tear deficiency. These data suggest that, at least in part, the beneficial clinical effects of CsA in DE can be attributed to a direct effect on sensory nerve endings, although the precise mechanisms underlying this effect need further studies to be fully clarified. 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Carmen true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PersonAuthorship 109653790 /api/authorship/109653790 Kovács, Illés ✉ [Kovács, Illés (Szemészet), szerző] Szemészeti Klinika (SE / AOK / K); Szemészeti Klinikai Ismeretek Tanszék (SE / ETK2007) 8 0.125 false true true Author 10025486 /api/author/10025486 Kovács Illés (Szemészet) Kovács Illés true 10025486 true Kovács Illés true false false AuthorshipType 1 /api/authorshiptype/1 Szerző 0 true 0 true false true PublicationIdentifier 24288321 /api/publicationidentifier/24288321 DOI: 10.3390/ijms241613025 PlainSource 6 /api/publicationsource/6 DOI PublicationSourceType 10001 /api/publicationsourcetype/10001 DOI true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.3390/ijms241613025 https://doi.org/10.3390/ijms241613025 false true PublicationIdentifier 24352885 /api/publicationidentifier/24352885 WoS: 001055334900001 PlainSource 1 /api/publicationsource/1 WoS PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001055334900001 https://www.webofscience.com/wos/woscc/full-record/001055334900001 true true PublicationIdentifier 24334616 /api/publicationidentifier/24334616 Scopus: 85169098312 PlainSource 3 /api/publicationsource/3 Scopus PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85169098312 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85169098312 true true PublicationIdentifier 29664289 /api/publicationidentifier/29664289 PubMed: 37629206 PlainSource 17 /api/publicationsource/17 PubMed PublicationSourceType 10003 /api/publicationsourcetype/10003 Indexelő adatbázis false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37629206 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37629206&dopt=Abstract true true SjrRating 11388415 /api/sjrrating/11388415 sjr:D1 (2023) Scopus - Inorganic Chemistry INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 7 0.1 journal RatingType 10002 /api/ratingtype/10002 sjr sjr true true ClassificationExternal 1604 /api/classificationexternal/1604 Scopus - Inorganic Chemistry true 1604 true D1 DIRECT true true Reference 44499435 /api/reference/44499435 1. 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(2023) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 1661-6596 1422-0067 24 16<div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10048316"><a href="/gui2/?type=authors&mode=browse&sel=10048316" target="_blank">Gyenes Andrea (<span class="authorship-author-name">Gyenes Andrea</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szemészeti Klinika</span> ;    <span class="author-name" >Tapasztó Zsófia </span> ;    <span class="author-name" >Quirce Susana </span> ;    <span class="author-name" >Luna Carolina </span> ;    <span class="author-name" >Frutos-Rincón Laura </span> ;    <span class="author-name" >Gallar Juana </span> ;    <span class="author-name" >Acosta M. Carmen </span> ;    <span class="author-name" mtid="10025486"><a href="/gui2/?type=authors&mode=browse&sel=10025486" target="_blank">Kovács Illés ✉ (<span class="authorship-author-name">Kovács Illés</span> <span class="authorAux-mtmt"> Szemészet</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Szemészeti Klinika; <span title="Semmelweis Egyetem">SE</span>/<span title="Egészségtudományi Kar">ETK2007</span>/Szemészeti Klinikai Ismeretek Tanszék</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34106852" target="_blank">Cyclosporine A Decreases Dryness-Induced Hyperexcitability of Corneal Cold-Sensitive Nerve Terminals</a></div> <div> <span class="journal-title">INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/1661-6596">1661-6596</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1422-0067">1422-0067</a>)</span>: <span class="journal-volume">24</span> <span class="journal-issue">16</span> <span class="page"> Paper 13025. 13 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.3390/ijms241613025" target="_blank" href="https://doi.org/10.3390/ijms241613025"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001055334900001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001055334900001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85169098312" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85169098312"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37629206" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37629206&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Inorganic Chemistry   SJR indikátor: D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Organic Chemistry   SJR indikátor: D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Spectroscopy   SJR indikátor: D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Computer Science Applications   SJR indikátor: Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)   SJR indikátor: Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Physical and Theoretical Chemistry   SJR indikátor: Q1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Catalysis   SJR indikátor: Q2</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Molecular Biology   SJR indikátor: Q2</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 6</span> | Független: 5 | Függő: 1 | Nem jelölt: 0 | WoS jelölt: 6 | Scopus jelölt: 6 | WoS/Scopus jelölt: 6 | DOI jelölt: 6 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34106852&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 2 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34106852</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">kézi felvitel</span> </div> <div class="funder"> (106649) Támogató: OTKA </div> <div class="lastModified">Utolsó módosítás: 2025.07.29. 11:12 Molnár-Taga Márta (SE 4-es admin) </div> <div class="lockedBy">Központi kezelésű 2025.12.18. 15:33 Wolf György (MTMT Központi admin) </div> </div></div>