https://m2.mtmt.hu/ hun 2026-09-21 12:33 JournalArticle 34105700 VALIDATED true Funding Agency and Grant Number: European Union [847879]; University Hospital Heidelberg, Germany; National Research Development and Innovation Office of Hungary [TKP2021-EGA-25] Funding text: We acknowledge all whose work has contributed to the knowledge we reported here. We thank Christian Schaaf for providing comments on an earlier version of the manuscript and Agota Apati for her recommendtaions concerning the revised manuscript. This work was funded from the European Union's Horizon 2020 research and innovation program under grant agreement No 847879. DS and SB were supported by the University Hospital Heidelberg, Germany. JMR and KV received funding from the National Research Development and Innovation Office of Hungary (Thematic grant TKP2021-EGA-25). 0 false 2026-08-12T21:55:35.823+0000 2023-08-22T07:02:07.583+0000 2023-08-21T13:55:45.093+0000 true 10027529 Apáti Ágota /api/author/10027529 Author true 10027529 2025-08-12T08:01:51.840+0000 2023-08-22T07:02:07.819+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 1134514 Survey paper true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/1134514 Összefoglaló cikk SubType 102 true 1134514 true 1 /api/category/1 Category true 1 Réthelyi, J.M. The role of insulin/IGF1 signalling in neurodevelopmental and neuropsychiatric disorders – Evidence from human neuronal cell models true true /api/journal/3369 REVIEWED true false 3369 false 3369 true 0149-7634 1873-7528 Journal FOREIGN 153 105330 105330 16 2023 Insulin and insulin-like growth factor 1 (IGF1) signalling play a central role in the development and maintenance of neurons in the brain, and human neurodevelopmental as well as neuropsychiatric disorders have been linked to impaired insulin and IGF1 signalling. This review focuses on the impairments of the insulin and IGF1 signalling cascade in the context of neurodevelopmental and neuropsychiatric disorders, based on evidence from human neuronal cell models. Clear evidence was obtained for impaired insulin and IGF1 receptor downstream signalling in neurodevelopmental disorders, while the evidence for its role in neuropsychiatric disorders was less substantial. Human neuronal model systems can greatly add to our knowledge about insulin/IGF1 signalling in the brain, its role in restoring dendritic maturity, and complement results from clinical studies and animal models. Moreover, they represent a useful model for the development of new therapeutic strategies. 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(<span class="authorship-author-name">Réthelyi János</span> <span class="authorAux-mtmt"> Pszichiátria- kognítiv idegtudomány</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10070227"><a href="/gui2/?type=authors&mode=browse&sel=10070227" target="_blank">Vincze K. (<span class="authorship-author-name">Vincze Katalin</span> <span class="authorAux-mtmt"> Pszichiátriai genetika.</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/Pszichiátriai és Pszichoterápiás Klinika; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Schall D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Glennon J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Berkel S. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34105700" target="_blank">The role of insulin/IGF1 signalling in neurodevelopmental and neuropsychiatric disorders – Evidence from human neuronal cell models</a></div> <div> <span class="journal-title">NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0149-7634">0149-7634</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1873-7528">1873-7528</a>)</span>: <span class="journal-volume">153</span> <span class="page"> Paper 105330. 16 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.1016/j.neubiorev.2023.105330" target="_blank" href="https://doi.org/10.1016/j.neubiorev.2023.105330"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001052878800001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001052878800001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85166952934" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166952934"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37516219" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37516219&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Behavioral Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Cognitive Neuroscience&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> <div class="journal-subject">Folyóirat szakterülete: Scopus - Neuropsychology and Physiological Psychology&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 26</span> | Független: 26 | Függő: 0 | Nem jelölt: 0 | WoS jelölt: 22 | Scopus jelölt:&nbsp;21 | WoS/Scopus jelölt:&nbsp;26 | DOI jelölt:&nbsp;26 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34105700&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 5 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34105700</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Összefoglaló cikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (TKP2021-EGA-25) </div> <div class="lastModified">Utolsó módosítás: 2023.08.22. 09:02 Molnár-Taga Márta (SE 4-es admin) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Funding Agency and Grant Number: European Union [847879]; University Hospital Heidelberg, Germany; National Research Development and Innovation Office of Hungary [TKP2021-EGA-25] Funding text: We acknowledge all whose work has contributed to the knowledge we reported here. We thank Christian Schaaf for providing comments on an earlier version of the manuscript and Agota Apati for he...</pre> </div></div>