Today, non-alcoholic fatty liver disease is the most common chronic liver disease,
yet there is no clearly accepted effective therapy. What is certain is that the number
of people suffering from the disease is increasing, making prevention, treatment and
recognition of co-morbidities of paramount importance. Current evidence suggests that
the development of non-alcoholic fatty liver disease may be due to pathological factors
of different origins. The main risk factors include genetic factors, acquired environmental
influences and lifestyle. Lifestyle modification, i.e., the elimination or reduction
of these harmful factors, can reverse liver damage, depending on the stage of the
disease. In this summary statement, we review the pathophysiology of non-alcoholic
fatty liver disease, risk factors and therapeutic options, within that in particular
lifestyle modification (dietary changes, increasing physical activity, weight loss).
Furthermore, we also show the importance of omega-3 fatty acids such as eicosapentaenoic
acid and docosahexaenoic acid in detail. With our knowledge, the personalized treatment
of non-alcoholic fatty liver disease can be elaborated. Orv Hetil. 2023; 164(33):
1294-1299.
