https://m2.mtmt.hu/ eng 2026-10-24 23:02 JournalArticle 34103632 VALIDATED true Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Neurosurgery, Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Doctoral School of Basic and Translational Medicine, Departments of Public Health, International Training Program in Geroscience, Translational Medicine and Physiology, Semmelweis University, Budapest, Hungary Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Veterans Affairs Medical Center, Oklahoma City, OK, United States Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Cited By :7 Export Date: 17 December 2024 CODEN: POLNC Correspondence Address: Yabluchanskiy, A.; Oklahoma Center for Geroscience and Healthy Brain Aging, United States; email: andriy-yabluchanskiy@ouhsc.edu Funding details: National Institute on Aging, NIA, K01AG073614, R03AG070479 Funding details: National Institute on Aging, NIA Funding details: National Cancer Institute, NCI, P30CA225520, R01AG055395, R01AG068295, R01CA255840, RF1AG072295 Funding details: National Cancer Institute, NCI Funding details: National Institute of Neurological Disorders and Stroke, NINDS, AHA966924, CX000340, R01AG075834, R01NS100782 Funding details: National Institute of Neurological Disorders and Stroke, NINDS Funding details: American Heart Association, AHA, 23DIVSUP1070991, AHA941290 Funding details: American Heart Association, AHA Funding text 1: The funders did not and will not have a role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. CO: NIA-supported Geroscience Training Program in Oklahoma (T32AG052363) CBP: American Heart Association (23DIVSUP1070991) ST: American Heart Association (AHA941290), National Institute on Aging (R03AG070479, K01AG073614), National Cancer Institute (P30CA225520) AC:National Cancer Institute (R01CA255840), National Institute on Aging (R01AG068295) ZU: National Institute on Aging (RF1AG072295, R01AG055395), National Institute of Neurological Disorders and Stroke (R01NS100782) CP: Department of Veterans Affairs Clinical Science Research & Development Service (CX000340) AY: American Heart Association (AHA966924), National Institute on Aging (R01AG075834). Fig 1 was created with BioRender.com. 0 false 2026-10-23T18:02:08.959+0000 2024-12-06T18:05:10.508+0000 2023-08-18T14:12:21.918+0000 true 10074555 Molnár-Taga Márta /api/admin/10074555 Admin true 2026-07-30T11:41:27.046+0000 2024-12-06T18:05:10.982+0000 true 10039043 Milánkovics Róbert /api/admin/10039043 Admin true 10039043 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Owens, C.D. Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 18 8 e0289508 e0289508 25 2023 INTRODUCTION: Mild cognitive impairment (MCI) is a prodromal stage to dementia, affecting up to 20% of the aging population worldwide. Patients with MCI have an annual conversion rate to dementia of 15-20%. Thus, conditions that increase the conversion from MCI to dementia are of the utmost public health concern. The COVID-19 pandemic poses a significant impact on our aging population with cognitive decline as one of the leading complications following recovery from acute infection. Recent findings suggest that COVID-19 increases the conversion rate from MCI to dementia in older adults. Hence, we aim to uncover a mechanism for COVID-19 induced cognitive impairment and progression to dementia to pave the way for future therapeutic targets that may mitigate COVID-19 induced cognitive decline. METHODOLOGY: A prospective longitudinal study is conducted at the University of Oklahoma Health Sciences Center. Patients are screened in the Department of Neurology and must have a formal diagnosis of MCI, and MRI imaging prior to study enrollment. Patients who meet the inclusion criteria are enrolled and followed-up at 18-months after their first visit. Visit one and 18-month follow-up will include an integrated and cohesive battery of vascular and cognitive measurements, including peripheral endothelial function (flow-mediated dilation, laser speckle contrast imaging), retinal and cerebrovascular hemodynamics (dynamic vessel retinal analysis, functional near-infrared spectroscopy), and fluid and crystalized intelligence (NIH-Toolbox, n-back). Multiple logistic regression will be used for primary longitudinal data analysis to determine whether COVID-19 related impairment in neurovascular coupling and increases in white matter hyperintensity burden contribute to progression to dementia. Copyright: © 2023 Owens et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. true true 2023 true true true false true false GOLD 2026-10-23 true https://doi.org/10.1371/journal.pone.0289508 14 0 14 9 5 14 14 13 14 14 14 9 9 9 5 0 14 9 14 9 0 29 29 Folyóiratcikk Journal Article 24 13 Könyvrészlet Chapter in Book 25 1 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet Chapter in Book 25 0 0 0 Könyv Book 23 0 0 0 Egyéb konferenciaközlemény Conference paper 31 0 0 0 Egyéb konferenciakötet Conference proceedings 32 0 0 0 Oltalmi formák Protection forms 26 0 0 0 Disszertáció Thesis 28 0 0 0 Egyéb Miscellaneous 29 0 0 0 Alkotás Achievement 22 0 0 0 Kutatási adat Research data 33 0 0 0 2023 0 1 1 1 1 2024 0 6 3 6 3 2025 0 6 4 6 4 2026 0 1 1 1 1 Q1 A false false false false 2023-08-17T14:20:38.135+0000 Doktori Iskola (SE); Népegészségtani Intézet (SE / AOK / I); Transzlációs Medicina Intézet (SE / AOK / I); Élettani Intézet (SE / AOK / I) 6 36 4 17 0 true Language 10002 /api/language/10002 Angol English true 2 true PersonAuthorship 109637238 /api/authorship/109637238 1 0.05882353 true false false Owens C.D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637239 /api/authorship/109637239 2 0.059 true false false Bonin Pinto C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637240 /api/authorship/109637240 3 0.059 true false false Author 10032249 /api/author/10032249 Mukli Péter true 10032249 true Mukli P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637241 /api/authorship/109637241 4 0.059 false false false Author 10078855 /api/author/10078855 Szarvas Zsófia true true Szarvas Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637242 /api/authorship/109637242 5 0.059 false false false Author 10084061 /api/author/10084061 Péterfi Anna true true Peterfi A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637243 /api/authorship/109637243 6 0.05882353 false false false Detwiler S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637244 /api/authorship/109637244 7 0.05882353 false false false Olay L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637245 /api/authorship/109637245 8 0.05882353 false false false Olson A.L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637246 /api/authorship/109637246 9 0.05882353 false false false Li G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637247 /api/authorship/109637247 10 0.05882353 false false false Galvan V. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637248 /api/authorship/109637248 11 0.05882353 false false false Kirkpatrick A.C. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637249 /api/authorship/109637249 12 0.05882353 false false false Balasubramanian P. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637250 /api/authorship/109637250 13 0.059 false false false Author 10074557 /api/author/10074557 Tarantini Stefano true true Tarantini S. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637251 /api/authorship/109637251 14 0.059 false false false Author 10071157 /api/author/10071157 Csiszar Anna true true Csiszar A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637252 /api/authorship/109637252 15 0.059 false false false Author 10043602 /api/author/10043602 Ungvári Zoltán István true 10043602 true Ungvari Z. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637253 /api/authorship/109637253 16 0.05882353 false false false Prodan C.I. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109637254 /api/authorship/109637254 17 0.059 false true true Yabluchanskiy A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24279952 /api/publicationidentifier/24279952 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GOLD true IDENTICAL 10.1371/journal.pone.0289508 https://doi.org/10.1371/journal.pone.0289508 false true PublicationIdentifier 24352510 /api/publicationidentifier/24352510 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001043333000072 https://www.webofscience.com/wos/woscc/full-record/001043333000072 true true PublicationIdentifier 24279951 /api/publicationidentifier/24279951 PlainSource 3 /api/publicationsource/3 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true Scopus Scopus http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-@@@ true true 3 true IDENTICAL 85166510204 http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166510204 false true PublicationIdentifier 24285810 /api/publicationidentifier/24285810 PlainSource 17 /api/publicationsource/17 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true PubMed PubMed http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=@@@&dopt=Abstract true true 17 true IDENTICAL 37535668 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37535668&dopt=Abstract true true Keyword 1 /api/keyword/1 true 1 true Keyword 1 /api/keyword/1 true 1 true Keyword 50 /api/keyword/50 true 50 true Keyword 50 /api/keyword/50 true 50 true Keyword 65 /api/keyword/65 true 65 true Keyword 1105 /api/keyword/1105 true 1105 true Keyword 2360 /api/keyword/2360 true 2360 true Keyword 2360 /api/keyword/2360 true 2360 true Keyword 3122 /api/keyword/3122 true 3122 true Keyword 4037 /api/keyword/4037 true 4037 true Keyword 5950 /api/keyword/5950 true 5950 true Keyword 14216 /api/keyword/14216 true 14216 true Keyword 14302 /api/keyword/14302 true 14302 true Keyword 17697 /api/keyword/17697 true 17697 true Keyword 1003763 /api/keyword/1003763 true 1003763 true Keyword 1008879 /api/keyword/1008879 true 1008879 true Keyword 1009586 /api/keyword/1009586 true 1009586 true Keyword 1012089 /api/keyword/1012089 true 1012089 true Keyword 1030096 /api/keyword/1030096 true 1030096 true Keyword 1186082 /api/keyword/1186082 true 1186082 true Keyword 1496899 /api/keyword/1496899 true true Keyword 1498053 /api/keyword/1498053 true true Keyword 2006271 /api/keyword/2006271 true true Keyword 2016151 /api/keyword/2016151 true true MtaRating 10486385 /api/mtarating/10486385 RatingType 10023 /api/ratingtype/10023 PedTB Institute 14107 /api/institute/14107 0 false true false Pedagógiai Tudományos Bizottság Pedagógiai Tudományos Bizottság true 14107 true true true A true true MtaRating 519076 /api/mtarating/519076 RatingType 10007 /api/ratingtype/10007 SZTB Institute 14102 /api/institute/14102 0 false true false Szociológiai Tudományos Bizottság Committee on Sociology true 14102 true true true A nemzetközi true 19076 true MtaRating 11551131 /api/mtarating/11551131 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi true true SjrRating 11400910 /api/sjrrating/11400910 19 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true Q1 DIRECT true true /api/publication/34103632 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Owens C.D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bonin Pinto C.<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli P.<sup>*</sup> (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078855"><a href="/gui2/?type=authors&mode=browse&sel=10078855" target="_blank">Szarvas Z. (<span class="authorship-author-name">Szarvas Zsófia</span> <span class="authorAux-mtmt"> Megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084061"><a href="/gui2/?type=authors&mode=browse&sel=10084061" target="_blank">Peterfi A. (<span class="authorship-author-name">Péterfi Anna</span> <span class="authorAux-mtmt"> Megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Detwiler S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Olay L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Olson A.L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Li G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Galvan V. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kirkpatrick A.C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Balasubramanian P. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini S. (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar A. (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Z. (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Prodan C.I. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy A. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34103632" target="_blank">Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">8</span> <span class="page"> Paper e0289508. 25 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0289508" target="_blank" href="https://doi.org/10.1371/journal.pone.0289508"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001043333000072" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001043333000072"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85166510204" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166510204"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37535668" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37535668&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság HASSPHSII PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Committee on Sociology HASSELIX SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Committee on Regional Studies HASSELIX RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 14</span> | Independent citation: 9 | Self citation: 5 | Unknown citation: 0 | Number of citations in WoS: 13 | Number of citations in Scopus:&nbsp;14 | WoS/Scopus assigned:&nbsp;14 | Number of citations with DOI:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34103632&sort=publishedYear,desc&sort=title"> Number of cited publications: 29 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34103632</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Last Modified: 2024.12.06. 19:05 Róbert Milánkovics (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Comments</u>: Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Neurosurgery, Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Doctoral School of Bas...</pre> </div></div>