https://m2.mtmt.hu/ hun 2026-09-21 04:37 JournalArticle 34103632 VALIDATED true Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Neurosurgery, Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Doctoral School of Basic and Translational Medicine, Departments of Public Health, International Training Program in Geroscience, Translational Medicine and Physiology, Semmelweis University, Budapest, Hungary Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Veterans Affairs Medical Center, Oklahoma City, OK, United States Department of Medicine, Cardiovascular Section, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Cited By :7 Export Date: 17 December 2024 CODEN: POLNC Correspondence Address: Yabluchanskiy, A.; Oklahoma Center for Geroscience and Healthy Brain Aging, United States; email: andriy-yabluchanskiy@ouhsc.edu Funding details: National Institute on Aging, NIA, K01AG073614, R03AG070479 Funding details: National Institute on Aging, NIA Funding details: National Cancer Institute, NCI, P30CA225520, R01AG055395, R01AG068295, R01CA255840, RF1AG072295 Funding details: National Cancer Institute, NCI Funding details: National Institute of Neurological Disorders and Stroke, NINDS, AHA966924, CX000340, R01AG075834, R01NS100782 Funding details: National Institute of Neurological Disorders and Stroke, NINDS Funding details: American Heart Association, AHA, 23DIVSUP1070991, AHA941290 Funding details: American Heart Association, AHA Funding text 1: The funders did not and will not have a role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. CO: NIA-supported Geroscience Training Program in Oklahoma (T32AG052363) CBP: American Heart Association (23DIVSUP1070991) ST: American Heart Association (AHA941290), National Institute on Aging (R03AG070479, K01AG073614), National Cancer Institute (P30CA225520) AC:National Cancer Institute (R01CA255840), National Institute on Aging (R01AG068295) ZU: National Institute on Aging (RF1AG072295, R01AG055395), National Institute of Neurological Disorders and Stroke (R01NS100782) CP: Department of Veterans Affairs Clinical Science Research & Development Service (CX000340) AY: American Heart Association (AHA966924), National Institute on Aging (R01AG075834). 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Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study true true /api/journal/10007440 REVIEWED true false 10007440 false 10007440 true 1932-6203 Journal FOREIGN 18 8 e0289508 e0289508 25 2023 INTRODUCTION: Mild cognitive impairment (MCI) is a prodromal stage to dementia, affecting up to 20% of the aging population worldwide. Patients with MCI have an annual conversion rate to dementia of 15-20%. Thus, conditions that increase the conversion from MCI to dementia are of the utmost public health concern. The COVID-19 pandemic poses a significant impact on our aging population with cognitive decline as one of the leading complications following recovery from acute infection. Recent findings suggest that COVID-19 increases the conversion rate from MCI to dementia in older adults. Hence, we aim to uncover a mechanism for COVID-19 induced cognitive impairment and progression to dementia to pave the way for future therapeutic targets that may mitigate COVID-19 induced cognitive decline. METHODOLOGY: A prospective longitudinal study is conducted at the University of Oklahoma Health Sciences Center. Patients are screened in the Department of Neurology and must have a formal diagnosis of MCI, and MRI imaging prior to study enrollment. Patients who meet the inclusion criteria are enrolled and followed-up at 18-months after their first visit. Visit one and 18-month follow-up will include an integrated and cohesive battery of vascular and cognitive measurements, including peripheral endothelial function (flow-mediated dilation, laser speckle contrast imaging), retinal and cerebrovascular hemodynamics (dynamic vessel retinal analysis, functional near-infrared spectroscopy), and fluid and crystalized intelligence (NIH-Toolbox, n-back). Multiple logistic regression will be used for primary longitudinal data analysis to determine whether COVID-19 related impairment in neurovascular coupling and increases in white matter hyperintensity burden contribute to progression to dementia. Copyright: © 2023 Owens et al. 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14102 true true true A nemzetközi true 19076 true MtaRating 11551131 /api/mtarating/11551131 RatingType 10010 /api/ratingtype/10010 RegTB Institute 14100 /api/institute/14100 0 false true false Regionális Tudományok Bizottsága Committee on Regional Studies true 14100 true true true B nemzetközi false true SjrRating 11400910 /api/sjrrating/11400910 19 0.24 journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true Q1 DIRECT true true /api/publication/34103632 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" >Owens C.D. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Bonin Pinto C.<sup>*</sup> </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli P.<sup>*</sup> (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Élettani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10078855"><a href="/gui2/?type=authors&mode=browse&sel=10078855" target="_blank">Szarvas Z. (<span class="authorship-author-name">Szarvas Zsófia</span> <span class="authorAux-mtmt"> Megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084061"><a href="/gui2/?type=authors&mode=browse&sel=10084061" target="_blank">Peterfi A. (<span class="authorship-author-name">Péterfi Anna</span> <span class="authorAux-mtmt"> Megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Detwiler S. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Olay L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Olson A.L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Li G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Galvan V. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kirkpatrick A.C. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Balasubramanian P. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10074557"><a href="/gui2/?type=authors&mode=browse&sel=10074557" target="_blank">Tarantini S. (<span class="authorship-author-name">Tarantini Stefano</span> <span class="authorAux-mtmt"> népegészségtan, gerontológia, molekuláris bioló...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071157"><a href="/gui2/?type=authors&mode=browse&sel=10071157" target="_blank">Csiszar A. (<span class="authorship-author-name">Csiszar Anna</span> <span class="authorAux-mtmt"> Orvostudomany</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10043602"><a href="/gui2/?type=authors&mode=browse&sel=10043602" target="_blank">Ungvari Z. (<span class="authorship-author-name">Ungvári Zoltán István</span> <span class="authorAux-mtmt"> Orvostudomány, megelőző orvostan, népegészségta...</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Népegészségtani Intézet; <span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Intézet">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis Egyetem">SE</span>/Doktori Iskola</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Prodan C.I. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Yabluchanskiy A. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34103632" target="_blank">Vascular mechanisms leading to progression of mild cognitive impairment to dementia after COVID-19: Protocol and methodology of a prospective longitudinal observational study</a></div> <div> <span class="journal-title">PLOS ONE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/1932-6203">1932-6203</a>)</span>: <span class="journal-volume">18</span> <span class="journal-issue">8</span> <span class="page"> Paper e0289508. 25 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_GOLD" title=" Gold "> <a style="color:blue" title="10.1371/journal.pone.0289508" target="_blank" href="https://doi.org/10.1371/journal.pone.0289508"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001043333000072" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001043333000072"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85166510204" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166510204"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37535668" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37535668&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;Q1</div> <div class="journal-subject">Pedagógiai Tudományos Bizottság II. FTO PedTB [1901-]&nbsp;&nbsp;&nbsp;A</div> <div class="journal-subject">Szociológiai Tudományos Bizottság IXGJO SZTB [1901-]&nbsp;&nbsp;&nbsp;A nemzetközi</div> <div class="journal-subject">Regionális Tudományok Bizottsága IXGJO RTB [1901-]&nbsp;&nbsp;&nbsp;B nemzetközi</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 14</span> | Független: 9 | Függő: 5 | Nem jelölt: 0 | WoS jelölt: 13 | Scopus jelölt:&nbsp;14 | WoS/Scopus jelölt:&nbsp;14 | DOI jelölt:&nbsp;14 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34103632&sort=publishedYear,desc&sort=title"> Idézett közlemények száma: 29 </a> </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34103632</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás Idéző | <span class="type-subtype">Folyóiratcikk ( Szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="lastModified">Utolsó módosítás: 2024.12.06. 19:05 Milánkovics Róbert (PTE ÁOK admin 4) </div> <pre class="comment" style="margin-top: 0; margin-bottom: 0;"><u>Megjegyzés</u>: Oklahoma Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Department of Neurosurgery, Vascular Cognitive Impairment, Neurodegeneration and Healthy Brain Aging Program, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States Doctoral School of Bas...</pre> </div></div>