https://m2.mtmt.hu/ hun 2026-09-22 12:43 JournalArticle 34103163 VALIDATED true 0 false 2026-07-15T08:38:26.547+0000 2023-10-05T08:48:48.280+0000 2023-08-18T08:39:57.144+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2023-10-19T15:05:50.065+0000 2023-10-19T15:05:50.065+0000 2023-08-18T08:43:28.778+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000359 Study Group true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000359 Sokszerzős vagy csoportos szerzőségű szakcikk SubType 104 true 10000359 true 1 /api/category/1 Category true 1 Neilan, T.G. Atorvastatin for Anthracycline-Associated Cardiac Dysfunction: The STOP-CA Randomized Clinical Trial true true /api/journal/2954 REVIEWED true false 2954 false 2954 true 0098-7484 1538-3598 Journal FOREIGN 330 6 528 536 528 9 2023 Importance: Anthracyclines treat a broad range of cancers. Basic and retrospective clinical data have suggested that use of atorvastatin may be associated with a reduction in cardiac dysfunction due to anthracycline use. Objective: To test whether atorvastatin is associated with a reduction in the proportion of patients with lymphoma receiving anthracyclines who develop cardiac dysfunction. Design, Setting, and Participants: Double-blind randomized clinical trial conducted at 9 academic medical centers in the US and Canada among 300 patients with lymphoma who were scheduled to receive anthracycline-based chemotherapy. Enrollment occurred between January 25, 2017, and September 10, 2021, with final follow-up on October 10, 2022. Interventions: Participants were randomized to receive atorvastatin, 40 mg/d (n = 150), or placebo (n = 150) for 12 months. Main Outcomes and Measures: The primary outcome was the proportion of participants with an absolute decline in left ventricular ejection fraction (LVEF) of ≥10% from prior to chemotherapy to a final value of <55% over 12 months. A secondary outcome was the proportion of participants with an absolute decline in LVEF of ≥5% from prior to chemotherapy to a final value of <55% over 12 months. Results: Of the 300 participants randomized (mean age, 50 [SD, 17] years; 142 women [47%]), 286 (95%) completed the trial. Among the entire cohort, the baseline mean LVEF was 63% (SD, 4.6%) and the follow-up LVEF was 58% (SD, 5.7%). Study drug adherence was noted in 91% of participants. At 12-month follow-up, 46 (15%) had a decline in LVEF of 10% or greater from prior to chemotherapy to a final value of less than 55%. The incidence of the primary end point was 9% (13/150) in the atorvastatin group and 22% (33/150) in the placebo group (P =.002). The odds of a 10% or greater decline in LVEF to a final value of less than 55% after anthracycline treatment was almost 3 times greater for participants randomized to placebo compared with those randomized to atorvastatin (odds ratio, 2.9; 95% CI, 1.4-6.4). Compared with placebo, atorvastatin also reduced the incidence of the secondary end point (13% vs 29%; P =.001). There were 13 adjudicated heart failure events (4%) over 24 months of follow-up. There was no difference in the rates of incident heart failure between study groups (3% with atorvastatin, 6% with placebo; P =.26). The number of serious related adverse events was low and similar between groups. Conclusions and Relevance: Among patients with lymphoma treated with anthracycline-based chemotherapy, atorvastatin reduced the incidence of cardiac dysfunction. This finding may support the use of atorvastatin in patients with lymphoma at high risk of cardiac dysfunction due to anthracycline use. Trial Registration: ClinicalTrials.gov Identifier: NCT02943590. © 2023 American Medical Association. All rights reserved. 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/api/ratingtype/10002 sjr true true ClassificationExternal 2701 /api/classificationexternal/2701 true 2701 true D1 DIRECT true true /api/publication/34103163 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <div class="autype autype0"> <span class="author-name" >Neilan T.G. ✉ </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10061268"><a href="/gui2/?type=authors&mode=browse&sel=10061268" target="_blank">Drobni Z.D. (<span class="authorship-author-name">Drobni Zsófia</span> <span class="authorAux-mtmt"> kardiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis Egyetem">SE</span>/<span title="Általános Orvostudományi Kar">AOK</span>/<span title="Klinikum">K</span>/<span title="Városmajori Szív- és Érgyógyászati Klinika">VAROSMAJOR_SZÍVÉRGYÓGY</span>/Kardiológia Központ - Kardiológiai Tanszék</span> ;&nbsp;&nbsp;&nbsp; et al. (35) </div> <div><a target="_blank" href="/api/publication/34103163?labelLang=hun">Összes szerző</a></div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34103163" target="_blank">Atorvastatin for Anthracycline-Associated Cardiac Dysfunction: The STOP-CA Randomized Clinical Trial</a></div> <div> <span class="journal-title">JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/0098-7484">0098-7484</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/1538-3598">1538-3598</a>)</span>: <span class="journal-volume">330</span> <span class="journal-issue">6</span> <span class="page"> pp 528-536 </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Nyelv: Angol | </span> <span class="identifiers"> <span class="id identifier oa_PAY" title=" Fizetős "> <a style="color:blue" title="10.1001/jama.2023.11887" target="_blank" href="https://doi.org/10.1001/jama.2023.11887"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001061433500020" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001061433500020"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85166783588" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85166783588"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37552303" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37552303&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Folyóirat szakterülete: Scopus - Medicine (miscellaneous)&nbsp;&nbsp;&nbsp;SJR indikátor:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="Nyilvános idézőközlemények összesen, említések nélkül" class="citingPub-count">Nyilvános idéző összesen: 157</span> | Független: 139 | Függő: 18 | Nem jelölt: 0 | WoS jelölt: 151 | Scopus jelölt:&nbsp;117 | WoS/Scopus jelölt:&nbsp;157 | DOI jelölt:&nbsp;154 </div> <div class="mtid"><span class="long-pub-mtid">Közlemény: 34103163</span> | <span class="status-data status-VALIDATED"> Egyeztetett </span> Forrás | <span class="type-subtype">Folyóiratcikk ( Sokszerzős vagy csoportos szerzőségű szakcikk ) </span> | <span class="pub-category">Tudományos</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (ÚNKP-22-4-II-SE) </div> <div class="lastModified">Utolsó módosítás: 2023.10.05. 10:48 Szalóky-Siki Ágnes (SE_KK_Admin5_SZSA, admin) </div> </div></div>