https://m2.mtmt.hu/ eng 2026-09-22 11:36 JournalArticle 34076330 VALIDATED true 0 false 2026-07-30T11:50:45.474+0000 2026-05-13T05:54:00.475+0000 2023-07-26T08:09:25.200+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2026-07-30T11:41:29.166+0000 2025-06-19T12:46:15.337+0000 true 10062062 Gere Tamásné /api/admin/10062062 Admin true 10062062 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Czoch, Á Resting-state fractal brain connectivity is associated with impaired cognitive performance in healthy aging true true /api/journal/10071822 REVIEWED true false 10071822 false 10071822 true 2509-2715 2509-2723 Journal FOREIGN 46 1 473 489 473 17 2024 Aging affects cognitive functions even in the absence of ongoing pathologies. The neurophysiological basis of age-related cognitive decline (CD), however, is not completely understood. Alterations in both functional brain connectivity and in the fractal scaling of neuronal dynamics have been linked to aging and cognitive performance. Recently, fractal connectivity (FrC) has been proposed — combining the two concepts — for capturing long-term interactions among brain regions. FrC was shown to be influenced by increased mental workload; however, no prior studies investigated how resting-state FrC relates to cognitive performance and plausible CD in healthy aging. We recruited 19 healthy elderly (HE) and 24 young control (YC) participants, who underwent resting-state electroencephalography (EEG) measurements and comprehensive cognitive evaluation using 7 tests of the Cambridge Neurophysiological Test Automated Battery. FrC networks were reconstructed from EEG data using the recently introduced multiple-resampling cross-spectral analysis (MRCSA). Elderly individuals could be characterized with increased response latency and reduced performance in 4–4 tasks, respectively, with both reaction time and accuracy being affected in two tasks. Auto- and cross-spectral exponents — characterizing regional fractal dynamics and FrC, respectively, — were found reduced in HE when compared to YC over most of the cortex. Additionally, fractal scaling of frontoparietal connections expressed an inverse relationship with task performance in visual memory and sustained attention domains in elderly, but not in young individuals. Our results confirm that the fractal nature of brain connectivity — as captured by MRCSA — is affected in healthy aging. Furthermore, FrC appears as a sensitive neurophysiological marker of age-related CD. 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<span class="author-name" mtid="10081142"><a href="/gui2/?type=authors&mode=browse&sel=10081142" target="_blank">Káposzta Z (<span class="authorship-author-name">Káposzta Zalán</span> <span class="authorAux-mtmt"> Fraktálélettan és Hálózatelméleti Analízis</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10032249"><a href="/gui2/?type=authors&mode=browse&sel=10032249" target="_blank">Mukli P. (<span class="authorship-author-name">Mukli Péter</span> <span class="authorAux-mtmt"> Élettan, megelőző orvostan és népegészségtan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Public Health; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet; <span title="Semmelweis University">SU</span>/School of PhD Studies</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10071680"><a href="/gui2/?type=authors&mode=browse&sel=10071680" target="_blank">Stylianou O. (<span class="authorship-author-name">Stylianou Orestis</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Transzlációs Medicina Intézet</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024096"><a href="/gui2/?type=authors&mode=browse&sel=10024096" target="_blank">Eke A. (<span class="authorship-author-name">Eke András</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10059431"><a href="/gui2/?type=authors&mode=browse&sel=10059431" target="_blank">Rácz FS ✉ (<span class="authorship-author-name">Rácz Frigyes Sámuel</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34076330" target="_blank">Resting-state fractal brain connectivity is associated with impaired cognitive performance in healthy aging</a></div> <div> <span class="journal-title">GEROSCIENCE: OFFICIAL JOURNAL OF THE AMERICAN AGING ASSOCIATION (AGE)</span> <span class="journal-issn">(<a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2715">2509-2715</a> <a target="_blank" href="https://portal.issn.org/resource/ISSN/2509-2723">2509-2723</a>)</span>: <span class="journal-volume">46</span> <span class="journal-issue">1</span> <span class="page"> pp 473-489 </span> <span class="year">(2024)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="10.1007/s11357-023-00836-z" target="_blank" href="https://doi.org/10.1007/s11357-023-00836-z"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001032615700001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001032615700001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85164974636" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85164974636"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37458934" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37458934&dopt=Abstract"> PubMed </a> </span> <span class="id identifier oa_NONE" title=" None "> <a style="color:blue" title="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164974636&doi=10.1007%2Fs11357-023-00836-z&partnerID=40&md5=d3b32cf24c0cd878564e74b11244e89f" target="_blank" href="https://www.scopus.com/inward/record.uri?eid=2-s2.0-85164974636&doi=10.1007%2Fs11357-023-00836-z&partnerID=40&md5=d3b32cf24c0cd878564e74b11244e89f"> Other URL </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Complementary and Alternative Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Veterinary (miscellaneous)&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> <div class="journal-subject">Journal subject: Scopus - Aging&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Cardiology and Cardiovascular Medicine&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> <div class="journal-subject">Journal subject: Scopus - Geriatrics and Gerontology&nbsp;&nbsp;&nbsp;Rank:&nbsp;Q1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 13</span> | Independent citation: 7 | Self citation: 6 | Unknown citation: 0 | Number of citations in WoS: 12 | Number of citations in Scopus:&nbsp;13 | WoS/Scopus assigned:&nbsp;13 | Number of citations with DOI:&nbsp;13 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34076330&sort=publishedYear,desc&sort=title"> Number of cited publications: 19 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34076330</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (ÚNKP-22– 3-1-SE-25), (121389/ DIDIT/2022), Az orvos-, egészségtudományi- és gyógyszerészképzés tudományos műhelyeinek fejlesztése(EFOP-3.6.3-VEKOP-16-2017-00009) Funder: EFOP-VEKOP </div> <div class="lastModified">Last Modified: 2026.05.13. 07:54 Edit Csajbók (SE_KK_Admin5_CSE, admin) </div> </div></div>