https://m2.mtmt.hu/ eng 2026-10-22 23:08 JournalArticle 34073578 VALIDATED true 0 false 2026-09-30T10:55:59.621+0000 2025-01-13T12:05:00.351+0000 2023-07-24T11:15:38.462+0000 true 10062250 Molnár-Taga Márta /api/admin/10062250 Admin true 10062250 2025-02-07T11:26:06.296+0000 2023-09-29T08:48:53.720+0000 true 10080205 Szalóky-Siki Ágnes /api/admin/10080205 Admin true Admin 10014568 /api/admin/10014568 Vándor Andrea true 10014568 true 2024-04-04T10:41:41.565+0000 true false true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle true 10000059 Article true 24 24 /api/publicationtype/24 PublicationType 1 true 24 JournalArticle /api/subtype/10000059 Szakcikk SubType 101 true 10000059 true 1 /api/category/1 Category true 1 Szanda, G. Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3 true true /api/journal/10088725 REVIEWED true false 10088725 false 10088725 true 2589-0042 Journal FOREIGN 26 7 107207 107207 23 2023 Molecular interactions between anorexigenic leptin and orexigenic endocannabinoids, although of great metabolic significance, are not well understood. We report here that hypothalamic STAT3 signaling in mice, initiated by physiological elevations of leptin, is diminished by agonists of the cannabinoid receptor 1 (CB1R). Measurement of STAT3 activation by semi-automated confocal microscopy in cultured neurons revealed that this CB1R-mediated inhibition requires both T cell protein tyrosine phosphatase (TC-PTP) and β-arrestin1 but is independent of changes in cAMP. Moreover, β-arrestin1 translocates to the nucleus upon CB1R activation and binds both STAT3 and TC-PTP. Consistently, CB1R activation failed to suppress leptin signaling in β-arrestin1 knockout mice in vivo, and in neural cells deficient in CB1R, β-arrestin1 or TC-PTP. Altogether, CB1R activation engages β-arrestin1 to coordinate the TC-PTP-mediated inhibition of the leptin-evoked neuronal STAT3 response. This mechanism may restrict the anorexigenic effects of leptin when hypothalamic endocannabinoid levels rise, as during fasting or in diet-induced obesity. © 2023 The Author(s) Funding 2029154 /api/funding/2029154 false true Funding 2029155 /api/funding/2029155 false true Funding 2029156 /api/funding/2029156 false true Funding 2029157 /api/funding/2029157 false true Funding 2029158 /api/funding/2029158 false true Funding 2029159 /api/funding/2029159 false true true 2023 true true true false true false GOLD 2026-09-30 true https://doi.org/10.1016/j.isci.2023.107207 8 0 8 6 1 8 8 7 8 8 8 6 6 6 2 0 8 6 8 6 0 12 12 Folyóiratcikk Journal Article 24 8 Könyvrészlet Chapter in Book 25 0 Könyv Book 23 0 Egyéb konferenciaközlemény Conference paper 31 0 Egyéb konferenciakötet Conference proceedings 32 0 Oltalmi formák Protection forms 26 0 Disszertáció Thesis 28 0 Egyéb Miscellaneous 29 0 Alkotás Achievement 22 0 Kutatási adat Research data 33 0 Folyóiratcikk Journal Article 24 0 0 0 Könyvrészlet 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false false false Jourdan T. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360459 /api/authorship/109360459 3 0.059 false false false Author 10052421 /api/author/10052421 Wisniewski Éva true 10052421 true Wisniewski É. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360460 /api/authorship/109360460 4 0.05882353 false false false Cinar R. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360461 /api/authorship/109360461 5 0.05882353 false false false Godlewski G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360462 /api/authorship/109360462 6 0.059 false false false Author 10055750 /api/author/10055750 Rajki Anikó true 10055750 true Rajki A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360463 /api/authorship/109360463 7 0.05882353 false false false Liu J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360464 /api/authorship/109360464 8 0.05882353 false false false Chedester L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360465 /api/authorship/109360465 9 0.059 false false false Author 10023428 /api/author/10023428 Szalai Bence true 10023428 true Szalai B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360466 /api/authorship/109360466 10 0.05882353 false false false Author 10047932 /api/author/10047932 Tóth András true 10047932 true Tóth A.D. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360467 /api/authorship/109360467 11 0.059 false false false Author 10024241 /api/author/10024241 Soltész-Katona Eszter true 10024241 true Soltész-Katona E. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360468 /api/authorship/109360468 12 0.059 false false false Author 10000772 /api/author/10000772 Hunyady László true 10000772 true Hunyady L. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360469 /api/authorship/109360469 13 0.05882353 false false false Inoue A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360470 /api/authorship/109360470 14 0.059 false false false Author 10084429 /api/author/10084429 Horváth Viktória Bea true true Horváth V.B. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360471 /api/authorship/109360471 15 0.059 false false false Author 10000514 /api/author/10000514 Spät András true 10000514 true Spät A. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360472 /api/authorship/109360472 16 0.05882353 false false false Tam J. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PersonAuthorship 109360473 /api/authorship/109360473 17 0.059 false true true Kunos G. true false false AuthorshipType 1 /api/authorshiptype/1 0 true 0 true false true PublicationIdentifier 24196039 /api/publicationidentifier/24196039 PlainSource 6 /api/publicationsource/6 PublicationSourceType 10001 /api/publicationsourcetype/10001 true true true DOI DOI https://doi.org/@@@ true true 6 true GREEN true IDENTICAL 10.1016/j.isci.2023.107207 https://doi.org/10.1016/j.isci.2023.107207 false true PublicationIdentifier 24417898 /api/publicationidentifier/24417898 PlainSource 1 /api/publicationsource/1 PublicationSourceType 10003 /api/publicationsourcetype/10003 false true true WoS WoS https://www.webofscience.com/wos/woscc/full-record/@@@ true true 1 true IDENTICAL 001059059100001 https://www.webofscience.com/wos/woscc/full-record/001059059100001 false true 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journal RatingType 10002 /api/ratingtype/10002 sjr true true ClassificationExternal 1000 /api/classificationexternal/1000 true 1000 true D1 DIRECT true true /api/publication/34073578 <div class="JournalArticle Publication long-list"> <div class="authors"> <img title="Forrásközlemény" style="float: left" src="/frontend/resources/grid/publication-core-icon.png"> <img title="Idézőközlemény" style="float: left" src="/frontend/resources/grid/publication-citation-icon.png"> <div class="autype autype0"> <span class="author-name" mtid="10015491"><a href="/gui2/?type=authors&mode=browse&sel=10015491" target="_blank">Szanda G. ✉ (<span class="authorship-author-name">Szanda Gergő</span> <span class="authorAux-mtmt"> Molekuláris Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Physiology">DP</span>/ELKH-SE Laboratory of Molecular Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Jourdan T. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10052421"><a href="/gui2/?type=authors&mode=browse&sel=10052421" target="_blank">Wisniewski É. (<span class="authorship-author-name">Wisniewski Éva</span> <span class="authorAux-mtmt"> Sejtélettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Cinar R. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Godlewski G. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10055750"><a href="/gui2/?type=authors&mode=browse&sel=10055750" target="_blank">Rajki A. (<span class="authorship-author-name">Rajki Anikó</span> <span class="authorAux-mtmt"> Endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/<span title="Department of Physiology">DP</span>/ELKH-SE Laboratory of Molecular Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Liu J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Chedester L. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10023428"><a href="/gui2/?type=authors&mode=browse&sel=10023428" target="_blank">Szalai B. (<span class="authorship-author-name">Szalai Bence</span> <span class="authorAux-mtmt"> számítógépes rendszerbiológia</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10047932"><a href="/gui2/?type=authors&mode=browse&sel=10047932" target="_blank">Tóth A.D. (<span class="authorship-author-name">Tóth András</span> <span class="authorAux-mtmt"> Élettan, belgyógyászat</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Clinical">C</span>/Belgyógyászati és Hematológiai Klinika; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10024241"><a href="/gui2/?type=authors&mode=browse&sel=10024241" target="_blank">Soltész-Katona E. (<span class="authorship-author-name">Soltész-Katona Eszter</span> <span class="authorAux-mtmt"> élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000772"><a href="/gui2/?type=authors&mode=browse&sel=10000772" target="_blank">Hunyady L. (<span class="authorship-author-name">Hunyady László</span> <span class="authorAux-mtmt"> molekuláris élettan, kísérletes endokrinológia</span>) </a> </span> <span class="author-affil"><span title="Research Centre for Natural Sciences">RCNS</span>/Institute of Enzymology; <span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Inoue A. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10084429"><a href="/gui2/?type=authors&mode=browse&sel=10084429" target="_blank">Horváth V.B. (<span class="authorship-author-name">Horváth Viktória Bea</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" mtid="10000514"><a href="/gui2/?type=authors&mode=browse&sel=10000514" target="_blank">Spät A. (<span class="authorship-author-name">Spät András</span> <span class="authorAux-mtmt"> Élettan</span>) </a> </span> <span class="author-affil"><span title="Semmelweis University">SU</span>/<span title="Faculty of Medicine">FM</span>/<span title="Instituties">I</span>/Department of Physiology</span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Tam J. </span> ;&nbsp;&nbsp;&nbsp; <span class="author-name" >Kunos G. ✉ </span> </div> </div> <div class="title"><a href="/gui2/?mode=browse&params=publication;34073578" target="_blank">Cannabinoid receptor type 1 (CB1R) inhibits hypothalamic leptin signaling via β-arrestin1 in complex with TC-PTP and STAT3</a></div> <div> <span class="journal-title">ISCIENCE</span> <span class="journal-issn">( <a target="_blank" href="https://portal.issn.org/resource/ISSN/2589-0042">2589-0042</a>)</span>: <span class="journal-volume">26</span> <span class="journal-issue">7</span> <span class="page"> Paper 107207. 23 p. </span> <span class="year">(2023)</span> </div> <div class="pub-footer"> <span class="language" xmlns="http://www.w3.org/1999/html">Language: English | </span> <span class="identifiers"> <span class="id identifier oa_GREEN" title=" Green "> <a style="color:blue" title="10.1016/j.isci.2023.107207" target="_blank" href="https://doi.org/10.1016/j.isci.2023.107207"> DOI </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="001059059100001" target="_blank" href="https://www.webofscience.com/wos/woscc/full-record/001059059100001"> WoS </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="85164348219" target="_blank" href="http://www.scopus.com/record/display.url?origin=inward&eid=2-s2.0-85164348219"> Scopus </a> </span> <span class="id identifier oa_none" title="none"> <a style="color:blue" title="37534180" target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=37534180&dopt=Abstract"> PubMed </a> </span> </span> <OnlyViewableByAuthor><div class="ratings"> <div class="journal-subject">Journal subject: Scopus - Multidisciplinary&nbsp;&nbsp;&nbsp;Rank:&nbsp;D1</div> </div></OnlyViewableByAuthor> <div class="publication-citation" style="margin-left: 0.5cm;"> <span title="" class="citingPub-count">Citing papers: 8</span> | Independent citation: 6 | Self citation: 2 | Unknown citation: 0 | Number of citations in WoS: 7 | Number of citations in Scopus:&nbsp;8 | WoS/Scopus assigned:&nbsp;8 | Number of citations with DOI:&nbsp;8 </div> <div class="publication-citation"> <a target="_blank" href="/api/publication?cond=citations.related;eq;34073578&sort=publishedYear,desc&sort=title"> Number of cited publications: 12 </a> </div> <div class="mtid"><span class="long-pub-mtid">Publication: 34073578</span> | <span class="status-data status-VALIDATED"> Validated </span> Core Citing | <span class="type-subtype">Journal Article ( Article ) </span> | <span class="pub-category">Scientific</span> | <span class="publication-sourceOfData">Scopus</span> </div> <div class="funder"> (NKFI-6/FK_124038), (FK_18 128376), (26303/AOELT/2019), (ELKH-SE Laboratory of Molecular Physiology Research Group), János Bolyai Research Scholarship of the Hungarian Academy of Sciences, (NVKP_16-1-2016-0039) Funder: NRDIO </div> <div class="lastModified">Last Modified: 2025.01.13. 13:05 Ágnes Szalóky-Siki (SE_KK_Admin5_SZSA, admin) </div> <div class="lockedBy">Centrally managed 2024.04.04. 12:41 Andrea Vándor (VA, admin) </div> </div></div>